Bibliography

Sections

INTRODUCTION
Part I: GENERAL AND REFERENCE WORKS
C
D
E
F
G
H
I
J
K
L
M
N
O
P
R
S
T
V
W
Z
Part II OPIUM POPPY,OPIUM AND DRUGS MANUFACTURED THEREFROM A, 1. Opium Poppy, Opium and Prepared Opium
A, 2. Analysis of Opium, its Preparations, and Determination of its Origin
B. Morphine A
B
C
D
F
G
H
L
M
N
P
R
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V
W
C. Other Phenanthrene Alkaloids and Derivatives (Under the Conventions) A
B
C
D
E
F
G
H
L
M
P
S
T
W
D. Other Drugs and Substances Derived from the Opium Poppy A
B
C
F
52 J
K
M
Q
R
S
T
W
Part III THE COCA LEAF AND DRUGS MANUFACTURED THEREFROM A
F
G
H
L
M
N
R
S
53 Part IV CANNABIS AND ITS DERIVATIVES
Part V SYNTHETIC DRUGS A. General Works A
B
C
F
G
H
K
L
M
P
S
W
Z
54 B. Pethidine and Related Compounds A
B
G
H
I
K
L
M
N
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C. Methadone and Related Compounds A
B
C
E
F
G
H
K
L
M
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56 D. Morphinan and Morphine Synthesis C
F
G
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57 E. Other Synthetic Drugs A
B
G
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Part VI ADDICTION TO NARCOTIC DRUGS A
B
C
D
E
F
G
H
I
L
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V
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Details

Pages: 47 to 59
Creation Date: 1951/01/01

Bibliography

SCIENTIFIC PUBLICATIONS ON NARCOTIC DRUGS FOR 1950

INTRODUCTION

The following bibliography has been prepared by the Secretariat and includes scientific publications on narcotic drugs which appeared during 1950, as well as a few which appeared in 1949 but could not, for technical reasons be included in our list for that year, published in the Bulletin on Narcotics, vol. II, no. 3.

This bibliography has no claim to be complete, and information regarding books or articles not included in it would be gratefully received by the Division of Narcotic Drugs, Department of Social Affairs, United Nations Secretariat.

The bibliography has been arranged by subject in the following fashion:

Part I. General and reference works;

Part II. Opium poppy, opium and drugs manufactured therefrom:

A. (1) Opium poppy, opium and prepared opium;

  1. Analysis of opium, its preparations and the determination of its origin;

B. Morphine;

C. Other phenanthrene alkaloids and derivatives (under the Conventions);

D. Other drugs and substances derived from the opium poppy;

Part III. The coca leaf and drugs manufactured therefrom;

Part IV. Cannabis and its derivatives;

Part V. The synthetic drugs:

A. General works;

B. Pethidine and related compounds;

C. Methadone and related compounds;

D. Morphinan and morphine synthesis;

E. Other synthetic analgesics;

Part VI. Addiction to narcotic drugs.

Under each heading, publications are arranged alphabetically by author. Due to the nature of the sources available to the Secretariat for preparing this bibliography, several of the titles are given in translation only. They are preceded by an asterisk.

Part I: GENERAL AND REFERENCE WORKS

B

BIETER, R. N.: Drugs used for the control of pain. Cincinnati Journal of Medicine, 1950, 31, 1-8.

BOIT, H.G.: Fortschritte der Alkaloid chemie seit 1933 (Progress of the chemistry of alkaloids since 1933). Akademie-Verlag. Berlin, 1950, 425 p.

BONNYCASTLE, D. D.; LEONARD, C. S.: An estimation of the activity of analgetic materials. Journal of Pharmacology and Experimental Therapeutics, 1950 ,100(2): 141-145.

BUCHEL, L.; LEVY, J.: Action analgésique; caractérisation; détermination quantitative. Anesthésie, 1949, 6, 257-74.

BUCHEL, L.; McILWAIN, H.: Narcotics and the phosphates of brain. Nature, 1950,/166:4215, 269-270.

C

CHATTERJEE, R.: The formation of alkaloids in plants. Science and Culture, 1950,/16, 58-60.

CHEN, K. K.: Physiological and pharmacological background, including methods of evaluation, of analgesic agents. Journal of the American Pharmaceutical Association, Scientific Edition, 1949, 38 (1): 51-55.

CLEMMESEN, C.: Centraliseret behandling af narkotiske forgiftninger i storkøvenhavn (Centralized handling of narcotics in greater Copenhagen). Ugeskrift for laeger, 1949, 111, 1085.

D

DELAY, J.; GERARD, H. P.: Les illusions de la mescaline. Encéphale, 1950, 39:1, 55-63.

DYER, I.: The present status of analgesia and anesthesia in obstetrics. New Orleans Medical and Surgical Journal, 1949, 102, 303-12.

E

EDDY, N. B.: The relation of chemical structure to analgesic action. Journal of the American Pharmaceutical Association, Scientific Edition, 1950, 39:5, 245-251.

EDITORS: Règles relatives à l'utilisation du carnet à souches pour prescription de stupéfiants. Semaine médicale (suppl. à la Semaine des Hopitaux), 1950, 26:31, p. 303.

EDITORS: Zakon o opojnim drogama (Law on narcotic substances). Farmaceutski Glasnik, 1950, 5, 3, 59-61.

F

FLUCK, H.: Unsere Heilpflanzen. (Our medicinal plants). 2nd ed. Thun. Otto-Verlag., 1950, 160 p.

G

GOODSON, L. H.; MOFFETT, R. B.: Analgesics. III. Hydrochlorides of phenyl-alkylamines. Journal of the American Chemical Society, 1949, 71, 3219-21.

GRUBER, Charles M., Jr.; GRUBER, Charles M.; LEE, Kwang Soo: Effect of certain analgesics upon intestine and uterine smooth muscle. Federation Proceedings, 1950, 9, 279.

H

HAMERSLAG, F. E.: The Technology and Chemistry of Alkaloids. New York: D. Van Nostrand Co., 1950, 327 p.

HARGER, R. N.; FORNEY, R. B.: An improved method for isolating alkaloids from body tissues. Journal of Pharmacology and Experimental Therapeutics, 1950, 12, 98(1).

HERAUD, A.: Dictionnaire des plantes médicinales. 7e édition, Paris. J. B. Baillière et Fils, 1949, 657 p.

HEWER, C. L.: Analgesia in childbirth. British Medical Journal, 1949, 2, 1521-3.

I

ISSEKUTZ, B., Jr.; LICHTNECKERT, I.; HETENYI, G., Jr.: Effect of narcotics on cell respiration. Archives Internation-ales de pharmacodynamie et de thérapie, 1950, 83, 33-48.

J

JINDRA, A.; POHORSKY, J.: Determination of alkaloids by exchange of ions. Journal of Pharmacy and Pharmacology, 1950, 2, 361-3.

K

KUHN, R. A.; BROMILEY, R. B.: Human pain thresholds determined by the radiant heat technique and the effect upon them of acetylsalicylic acid, morphine sulfate, and sodium phenobarbital. Journal of Pharmacology and Experimental Therapeutics, 1951, 101, 47-55.

L

LESPAGNOL, A.; MERCIER, F.; BERTRAND, J.; MERCIER, J.: Recherches dans la série des analgésiques. Annales pharmaceutiques françaises, 1950, 8:4, 241-261.

LEVI, A.: Sul sinergismo d'azione pa narcotici e mianesina (Synergism between narcotics and myanesin). Giornale Italiano di Anestesiologia , 1949, 15, 79-84.

LUCAS, G. H. W.: Crystal tests as a means of identifying alkaloids. Canadian Journal of Research, 1950, 28B, 37-42.

M

McNEALY, R. W.: A new analgesic combination for routine use in control of pain. Illinois Medical Journal, 1950, 97, 150.

MANSKE, R. H. F.; HOLMES, H. L.: The Alkaloids, Vol. 1, Chemistry and Physiology. New York: Academic Press, 1949, 525.

MEILLET, H.: Les prescriptions de stupéfiants. Concours médical, 1950. 72:33, 2513-2515.

MARY CARL, Sister: Narcotics in vials. Hospital Progress, 1950, 31:12, 356-7.

MOE, G. K.; SHIDEMAN, F. E.: Pharmacology. Annual Review of Physiology, 1949, 11: 565-586.

MOLDENSKE, Harold N.: (New York Botanical Garden, N.Y.C.) Poisonous plants of the world, 21 p., published by the Author: New York, 1948.

MOTHES, K.: Das Alkaloid problem (The alkaloid problem). Süddeutsche Apotheker-Zeitung, 1950, 90, 387-91.

MUNIER, R.; MACHEBOEUF, M.: Microchromatographie de partage des alkaloides et de diverses bases azotées biologiques. Bulletin de la société de chimie biologique, 1949, I, 1144-62.

MUNIER, R.; MACHEBOEUF, M.: Microchromatographie de partage des alcaloides et de diverses bases azotées biologiques. II. Utilisation de phases solvantes acides. Considérations sur l'importance chromatographique de la constante de dissociation des alcaloides. Bulletin de la société de chimie biologique, 1950, 32, 192-212.

MUNIER, Roger; MACHEBOEUF, Michel: Separation of nitrogen-containingbases through microchromatography in acid media. Compte Rendus de la Société de Biologie, 1950, 1177-9.

N

NAIM KENT, F. H.; MATEU AMEN-GUAL, B.: Identificación y separación de pequeñísimas cantidades de alcaloides por microcromatografía sobre papel (Identifi-cation and separation of minute quantities of alkaloids by microchromatography on paper). Archives de farmacia y bioquímia de Tucumán, 1950, 4, 333-43.

O

ORDRE DES PHARMACIENS: Substances vénéneuses. Paris, 1949, 84 p.

P

PAPPER, E. M.: An appraisal of some analgesic agents and methods. Pennsylvania Medical Journal, 1950, 53:8, 801-6.

PAPPER, E. M.; ROVENSTINE, E. A.: Newer analgesic methods and agents of value in the control of pain. New York State Journal of Medicine, 1950, 50, 281-5.

THE PHARMACOPEIA OF THE UNITED STATES OF AMERICA. 14th edition. Easton, Pennsylvania: Mack Printing Co., 1950, 1067 p.

POSTEMAK, J.; MANGOLD, R.: Action des narcotiques sur la conduction par les fibres nerveuses et leur potentiel de membrane. Helvetica physiologica et pharmacologica acta, 1949, 7, C55.

POUCHET CAMPOS, M. A.; ZEITUNI, J.: Microcrystalline alkaloid crystals with Mayer's reagent. Anais faculdade de farmacia e odontologia, 1949, Univ. Sao Paulo 7, 197-207.

R

RASKOVA, H. O.: Distribuci leciv (Distribution of drugs). Casopis Ceského Lékárnictva, 1950, 63:16, 182-7.

RAWLINGS, E. E.: Low spinal analgesia in operative obstetrics; a further series of 511 cases. British Medical Journal, 1950, 1, 412-4.

S

SCHNEITER, P.: Limitation de la fabrication et de la distribution des produits stupéfiants. Semaine médicale (suppl. à la Semaine des Hopitaux), 1950, 26:39, 563-564.

SZONTAGH, F. E.: Effect of narcotics and hypnotics on respiration volume and frequency. Hungarica Acta Physiologica, 1949, 2, 1-17.

T

THORNE, T. C.: Caudal analgesia. British Medical Journal, 1950, 1, 414-6.

V

VAILLE, Ch.; STERN, G.: Contribution à l'étude des toxicomanies. I. Contrôle du trafic licite des stupéfiants. Annales pharmaceutiques francaises, 1950, 8:7-8, 79-82.

VAILLE, Ch.; STERN, G.: La réglementation des substances vénéneuses.- Les toxicomanies. Paris, éditions du Creuset, 1949, 198 p.

VERWEY, A., Drogues narcotiques modernes. Chemische Weekblad, 1949, 45, 565-6.

VOLCKRINGER, J.: L'unification des pharmacopées. Presse médicale, 1949, 57, 881

VYHLASKA, C.: 457 ministerstva zdravotnictvi o priprave a vydeji leciv lekari a veterinari (Legislation of the Ministry of Health on preparation and issue of drugs to physicians and veterinarians). Casopis Ceského Lékárnictva, 1950, 63:15, 176.

W

WAKSMAN, S. A.; FENNER, F. ( et al): Drugs of natural origin. Annals of the New York Academy of Science, 1949, 52, 750-87.

WINDER, C. V.: (Parke, Davis & Co., Detroit, Mich.) Some examples of the use of statistics in pharmacology. I. An experiment in analgesimetry. II. A quantal concept of graded effect. III Chemorphological factorial design. Annals of the New York Academy of Science, 1950, 52(6): 838-861.

WOELKE, H.: Die Arzneidrogen (Medicinal drugs). Stuttgart: Wissenschaft. Verlag, 1950, 119 p.

Z

ZAUDER, H. L.: Effect of certain analgesic drugs and adrenal cortical hormones on the brain of normal and hypophysectomized rats as measured by the thiobarbituric acid reagent. Journal of Pharmacology and Experimental Therapeutics, 1951, 101, 40-6.

Part II OPIUM POPPY,OPIUM AND DRUGS MANUFACTURED THEREFROM A, 1. Opium Poppy, Opium and Prepared Opium

BAGGE, H.: Kulturfors ?g Med Opiat-Valmue 1941-1946 (Experiments on the culture of opium poppy in the years 1941-1946). Tidsskrift for Planteavl, 1948, 51(4) : 587-615.

BECKER, W. R., INDEMANS, A. W. M.: Het gehalte aan morphine en bijalkaloiden in het bolkaf van blauwmaanzaadrassen. (The content in morphine and minor alkaloids of the ashes of the blue poppy seeds). Pharmaceutisch Weekblad, 1949, 84, 669-75.

BENCZE, B.; FUSCHL, M.; NAGY, E. C.: Poppy ripening processes. Magyar Kémikusok ′lapja, 1949, 4, 711-13.

BERGER, H.: Die Rohopiumernte 1949 im Lande Sachsen-Anhalt (Raw opium harvested during 1949 in Sachsen-Anhalt). Pharmazie, 1950, 5:5, 239-241.

FULTON, Charles C.: Photomicrographs of opium crystals. United Nations Economic and Social Council document E/CN.7/117, 1948, part IIC, 32-47.

GERICKE, S.: Wirkung verschiedener Wachstumsfaktoren auf Ertrag und Oelgehalt vom Mohn (Action of several aspects of growth on the development and oil content of the opium poppy). Zeitschrift für Bodenkunde, und Pflanzenernährung Düng -und Bodenkunde, 1948, 40(1): 19-35.

HILLS, K. L.: RODWELL, C. N.: The recombination of some varietal characters in the opium poppy. Australian Journal of Agricultural Research, 1950, 1, 118-31.

NEHRING, K.: Aussaatzeit und N-Düngungsversuche zum Mohn (Sowing time and N-manuring experiments with poppy). Zeitschrift für Bodenkunde und Pflanzenernährung, Düng.- und Bodenkunde, 1948, 42(1) : 31-39.

PLICHET, A.: La production de l'opium dans le monde. Presse médicale, 1950, 58:33, 598-599.

UNITED NATIONS SECRETARIAT: Opium throughout the World. Bulletin on Narcotics, 1949, 1:1, 6-13, 26-38.

UNITED NATIONS SECRETARIAT : The Suppression of Poppy Cultivation in the United States. Bulletin on Narcotics, 1950, II, No. 3, 9-21.

A, 2. Analysis of Opium, its Preparations, and Determination of its Origin

AWE, W.; DEMELIUS, F.: Simplified preparations of tinctura opii simplex D. A.- B.6 and of opium Pharm. Helv. V. Apotheker Deutsche-Zeitung, 1949, 61, 81-2.

BAERHEIM SVENDSEN, Anders: Om kolorimetrisk bestemmelse av morfin i opium (The colorimetric determination of morphine in opium). Dansk Tidsskrift for Farmaci, 1948, 22(6) : 131-160.

BANDELIN, F. J.: The colorimetric determination of various alkaloids. Journal of the American Pharmaceutical Association, 1950, 39, 493-5.

DEMELIUS, F.: Comparative assays of opium and opium preparations according to the D. A.-B.6 and Mannich's method. Pharmazeutische Zeitung, 1950, 86, 50.I.

DREVON, B.; LAFITTE, G.: A proposda dosage de la morphine dans l'opium et ses préparations Annales pharmaceutiques francaises, 1950, 8, 397-401.

FOLCH JOU, G.: Los laudanos; formulas magistrales centenarias (Laudanum; centenary magistral formulas). Galénica Acta, 1949, 2:2, 49-72.

FULTON, Charles C.: On determining the origin of opium. United ..Nations Economic and Social Council document E/CN.7/117, 1948, part II A, 3-16.

FULTON, Charles C.: Methods of determining the origin of opium by chemical and physical means-Examinations of opium for distinguishing characteristics-Some tentative methods. United Nations Economic and Social Council document E/CN.7/117/Add.2, 1948.

FARMILO, C.G.; KENNETT, P. M. L.: Methods of Determining the Origin of Opium by Chemical and Physical Means-Further Data on "Porphyroxine-Meconidine". United Nations Economic and Social Council document E/CN.7/207, 1950.2-10.

GATTONI, A.: Determinazzione delle origini dell'ooppio (Determination of the origin of opium). Bollettino Chimico-farmaceutico, 1950, 89:5, 178-81.

GSTIRNER, F.; :VOLLMER, K.: Preparation of an alkaloid preparation from poppy seed-capsules. Apothekar Deutsche Zeitung, 1949, 61, 57-60.

IBARRA CORRALES, C.: Industrial extraction of morphine and codeine from the ripe capsules of Papaver somniferum. Farmacia Chilena, 1950, 24, 501-2.

ORAM, Joseph B.: Colorimetric determination of morphine. American Journal of Pharmacy, 1950, 122, 60-6.

Van PINXTEREN, J. A. C.; SMEETS, M. A. G.: De morphinebepaling in opium (Determination of morphine content of opium) Pharmaceutisch Weekblad, 1950, 85, 1-17, 48-59.

REITH, J. F.; INDEMANS, W. M.: De bepaling van morphine in hot bolkaf van blauwmaanzaad ( papaver somniferum L.). (Determination of morphine in the capsules of the blue poppy). Pharmaceutisch Weekblad, 1950, 85:17/18, 309-19.

ROZSA, P.: Tinctures available as substitutes for opium -tincture. Gy?dgyszer?sztud, 1948, 22, 162-7.

SAN MARTIN CASAMADA, R.; MOS-QUEIRA, Toribio A.: Determinación foto-colorimétrica de la morfina (Photocolori-metric determination of morphine). Anales de la Academia. de Farmacia, 1949, 15, 343-8.

SMEETS, M. A. G.: De Morphinebepaling in opium (The determination of morphine content in opium). Thesis, Rijks Universiteit, Utrecht, 1949.

UNITED NATIONS SECRETARIAT: Determining the origins of opium. Bulletin on Narcotics, 1949, I.: 1, 14-19, 42-47.

UNITED NATIONS SECRETARIAT: Methods of Determining the Origin of Opium by Chemical and Physical Means - The Comparative Determination of "Porphyroxine-Meconidine". United Nations Economic and Social Council document E /C N.7/195, 1950, 2-10.

UNITED NATIONS SECRETARIAT: Methods of Determining the Origin of Opium by Chemical and Physical Means - Determination of Codeine in the Lime-Water Extract United Nations Economic and Social Council document E / CN.7/202, 1950, 2-18.

UNITED NATIONS SECRETARIAT: The Assay, Characteristics, Composition, and Origin of Opium - The Determination of Morphine in Opium by Extraction: A New Method. United Nations Secretariat document ST /SOA/SER.K/1, 1951, 2-20.

WEGNER, Erich: Beitrag zur photometrischen Bestimmung der Mohalka. loide. Die Bestimmung von Codein, The bain and Narkotin in reinen Lösungen (Photometric determination of poppy alkaloids. Determination of codeine, the, baine, and narcotine in pure solutions). Pharmazie, 1950, 5, 33-5.

WEGNER; E.:- Beitrag zur-photometrischen Bestimmung der Mohnalkaloide. Die fluorophotometrische Bestimmung des Papaverins (Photometric determination of poppy alkaloids. Fluorimetric determination of papaverine). Pharmazie, 1950, 5, 445-7.

B. Morphine A

ABOOD, L. G.: Effect of morphine in vivo and in vitro on glycolysis of rat tissues. Federation Proceedings, 1950, 9(1): 252.

ABOOD, L. G.; KUN, Ernest;GEILING, E. M. K.: Phosphorylated intermediates of chronically and acutely morphinized rats . Journal of Pharmacology and. Experimental Therapeutics, 1950, 98 (4): -373-379.

ALBERTY, J.: Der Einfluss der Neben alkaloide des Opiums auf die analgetische Wirkung des Morphins (The influence of minor alkaloid of opium on the analgesic action of morphine). Archiv für experimentelle Pathologie, 1949, 208, 179.

ARKEL, C. G. Van; WAERT, J. H. van: De ontleding van morphine hydrochloride-oplossingen bij sterilisatie (The decom-position of morphine hydrochloride solutions during sterilization). Pharmaceutisch Weekblad, 1950, 85: 17/18, 319-21.

ARTUSIO, Jr., J. F.; TROUSDELL, M.: A comparative study of rectal pentothal and morphine tot basal anesthesia upon children for tonsillectomy. Anesthesiology, 1950, 11:3, 443-51.

B

DeBOER, B.; FOSTER, R. H. K.: Respiratory depression in rabbits following administration of NU-2206, morphine sulfate, and piperidine analgesic. Journal of Pharmacology and Experimental Thera-peutics, 1950, 98 (1) :6.

BROTMAN, M.; CULLEN, S. C.: Intravenous supplementation during nitrousoxide, anesthesia. II. Comparison of morphine, meperidine, and a new potent analgesic (NU-2206) with the application of multiple covariance analysis. Journal of Pharmacology and Experimental Thera-peutics, 1950, 98(1) : 4.

BURKE, J. O.; PLUMMER, K.; BRAD-FORD, S.: Serum-amylase response to morphine, mecholyl, and secretin as a test of pancreatic function. Gastroenterology, 1950, 15, 699-707.

C

CREYX, M.; COZAUX, P.; LIDON, P.:A propos du chlorhydrate de morphine Actuel. Bulletin des Travaux de la Société de Pharmacie de Bordeaux, 1950, 88, II.

D

DOGLIOTTI, M.: L'eosinofilia locale nei pomfi allergici e nei pomfi da morfina. (local eosinophilia in abscesses due to allergy and to the use of morphine) Dermo-sifilografo, 1949, 24, 326-34.

F

FLINT, W. F.: Morphine mucate in labour and obstetric practice . Journal of Obstetrics and Gynaecology, 1949, 56(1) : 54-57.

FORST, A. W.; DEININGER, R.: Eine neue Methode zum spezifischen biologischen Nachweis von Morphin im Harn an der Mausepupille (Specific biologic deter-mination of morphine in urine; a method using the mouse pupil). Archiv für Experimentelle Pathologic, 1949, 206, 416-438.

FOSTER, G. E.; MacDONALD, J.; WHITTET, T. D.: Stability of morphinesulfate injection. Journal of Pharmacy and Pharmacology, 1950, 2, 673-83.

FREESE, H. B.; BIANCHI, R. G.; HAMBOURGER, W. E.: Morphine induced emesis in dogs treated with β-di-methylamino-ethylbenzohydrylether-8-chlor-otheophylinate (Dramamine). Federation Proceedings, 1950, 9(1) : 274.

G

GIRARD, P.: Sur la conservation et le controle des solutions injectables de morphine, Annales pharmaceutiques francaises, 1950, 8:7-8, 571-4.

GRUBER, C. M., Jr.; LEE; K. S.; GRUBER, C. M.: A. comparison of the actions of meperidine, Nu-1196, methadone morphine, Nu-2206, and metopon upon the intestine and uterus. Journal of Pharma-cology and Experimental Therapeutics, 1950; 99:3, 317-24.

H

HANDLEY, Carroll A.; KELLER, Allen D.: Changes in renal function produced by morphine in normal dogs and dogs with diabetes insipidus. Journal of Pharmacology and Experimental Therapeutics, 1950,99, 33-7. van den HEUVEL, G.: Effect of morphine on blood sugar. Archives Internationales de Pharmacodynamie et de Thérapie, 1950, LXXXI, III, 385-386. van den HEUVEL, G.; HEYMANS, C.: Mécanisme de l'action hypérglycémiante de l'acétylcholine, de la morphine et de la nicotine. Archives Internationales de Pharmacodynamie et de Thérapie, 1950, 83, 386-416.

HILTZ, K.; OBERNBERG, H. von: Ueber die erregende Wirkung von Morphin bei der weissen Maus und deren Verstärkung durch Veronal; eine neue Methode zur genauen zeitlichen Analyse des Erregungsablaufes (Stimulating effect of morphine onthe white mouse and its aggravation by veronal; a new method of exact chronological analysis of the course of the stimulation). Berliner und Münchener Tierärztliche Wochenschrift,1950, 10, 2167.

HOFFMAN, H.: Ueber die Beeniflussung der Morphinempfindlichkeit der Maus durch Thymusextract (Effect of Thymus extract on morphine sensitivity of the. mouse). Endokrinologie,1949, 26, 149 56.

HOLCK, H. G. O.; KIMURA, K.; KIMURA, T.: Comparison of analgetic activity of sixty-seven ?ryl-alkamines with that of morphine and meperidine by the mouse hot-plate method. Journal of the American Pharmaceutical Association,1950, 39, 354-9.

HOUDE, R. W.; SEEVERS, M. H.; PURCELL, F.; IRWIN, S.: Effects of morphine, meperidine, and methadon on the reflex reaction times of spinal animals. Journal of Pharmacology and Experimental Therapeutics, 1950, 98(1): 14.

L

LEDRUT, J. H. T.: Double camphorate of hyoscyamine and morphine. U.S. patent 2,491,741, 20December 1949.

LEIMDORFER, A.: An electroencephalographic analysis of the action of amidone, morphine and strychnine on the central nervous system. Archives Internationales de Pharmacodynamie et de Thérapie,1948,76(2): 153-162.

M

McINTOSH, B. J.; KELSEY, F. E.; GEILING, E. M. K.: Biosynthesis of radioactive morphine. Journal of Pharmacology and Experimental Therapeutics,1950, 98(1), 23.

McINTOSH, B. J.; KELSEY, F. E.; GEILING, E. M. K.: The preparation of radio-active morphine and related alkaloids by biosynthesis. Journal of the American Pharmaceutical Association. Scientific Edition,1950, 39:9, 512-5.

N

NOSEK, J.; KRESTYNOVA, O.: Polarografie morfinu (Morphine polarography). Casopis Geského Lékárnictva Vedecka Priloha, 1950, 63:3-4, 49-51.

P

PORCHER, P.; BOURDON, R. (et al): Bilan de la morphine après 6.000 examens. Archives des maladies de l'appareil digestif, 1949, 38, 942-4.

R

RIETH, K. H.; SCHADER, H. E.: Klinische Erfahrungen mit einem neuen Morphinnachweis (Clinical experience with a new test for morphine). Münchener Medizinische Wochenschrift,1950, 92:21-22, 1049-51.

ROWLANDS, E. N.; CHAPMAN, W. P.; TAYLOR, A.; JONES, C. M.: Multiple balloon kymograph recording of the comparative action of morphine and placeboson the motility of the upper small intestine in man. Surgery, Gynecology and Obstetrics,1950, 91:2, 129-37.

S

SANTARATO, R.; LENARDON, B.: Azioni enzimatiche della morfina e dei morfinosimili di sintesi. I. Respirazione dei tessuti nervoso centrale, epatico e muscolare di topi bianchi intossicati acutamente e cronicamente con morfina, amidone e dolantina (Enzymatic, action of morphine and synthetic morphine substitutes. Respiration of central nervous, hepatic and muscular tissue of white mice acutely and chronically intoxicated with morphine, amidone and dolantin). Acta Anaesthesiologica,1950, 1:4, 338-44.

SARGENT, L. J.; SMALL, L. F.: On the structure of morphine and its derivative Metopon. Science,1950, 112:2912, 473.

SCIGLIANO, J. A.; PURDUM, W. A.; FOSS, N. E.: The manufacture, solubility of hypodermic tablets containing morphine salts. Journal of the American Pharmaceutical Association, 1950, 39:11, 627-9.

SHAW, F. H.; BENTLEY, G.: Some aspects of the pharmacology of morphine with special reference to its antagonism by 5-amino-acridine and other chemically related compounds. Medical Annals of the District of Colombia, 1950, 19, 868-74.

SIEGEL, B. M.; BLOCH, D. P.; PITESKY, I; LAST,J. H.: Comparative study of morphine and dromoran as antidiuretic agents in the dog. Proceedings of the Society for Experimental Biology and Medicine, 1950, 74:4, 809-12.

V

VOGELENZANG, E. H.: Morphine en vervangmiddelen (Morphine and substitutes). Pharmaceutisch Weekblad, 1950, 85:27-28, 497-508.

W

WIKLER, Abraham; ALTSCHUL, Sol: Effects of methadone and morphine on the electroencephalogram of the dog. Journal of Pharmacology and Experimental Therapeutics, 1950, 98: 4, part I, 437-46.

WILLIAMS, E. M. V.; STREETEN, D. H. P.: The action of morphine, pethidine, and amidone upon the intestinal motility of conscious dogs. British Journal of Pharmacology, 1950, 5, 584-603.

C. Other Phenanthrene Alkaloids and Derivatives (Under the Conventions) A

ADLER, T. K.; LATHAM, M. E.: Demethylation of C 14-labelled codeine in the rat. Proceedings of the Society of Experimental Biology and Medicine, 1950, 73(3): 401-404.

AMOROSA, M.: The chemical constitution of pseudomorphine (oxydimor-phine, dehydrodimorphine). Gazzetta Chi-mica Italiana, 1949, 79, 886-91.

B

BAIZER, M. M.; ELLNER, K. S.: A Convenient Laboratory. Preparation of Ethylmorphine Hydrochloride, U.S.P. XIII. Journal of the American Pharmaceutical Association, Scientific Edition, 1950, 39 (10): 581-583.

C

CASPARIS, P.: Su alcuni derivati della morfina e loro azione analgesica (Some morphine derivatives and their analgesic action). Bollettino Chimico-farmaceutico, 1950, 89:8, 309-18.

CHABRIER, P.; GIUDICELLI, R.; THUILLIER, J.: Etude clinique, phar-macologique et clinique d'un nouveau séda-tif de la toux: la morpholylethylmorphine (M.E.M.). Annales pharmaceutiques françaises, 1950, 8:4, 261-73.

CHANG, F. N. H.; ONETO, J.F.; SAH, P. P. T.; TOLBERT, B. M.; RAPOPORT, H.: The synthesis of codeine labelled in 3-methoxy group with C 14. Journal of Organic Chemistry, 1950, 15, 634-6.

D

DEROBERT, L.; LeBRETON, R.; MICHON; HAFFAR: Recherches expérimentales et cliniques sur certaines modifi-cations biologiques survenues durant une intoxication chronique par I'héroïne. Annales de médecine, légale, criminologie, police scientifique, médecine social et toxicologie, 1950, 30, 232-3.

DORDONI, F.: Dionine and histamine: the mechanism of production of conjunctival chemosis by dionine and the tolerance developed to the local action of the drug. Bollettino d'oculistica, 1948, 27, 20-40.

DROMMOND, F. G.; JOHNSON, C. C.; POE, C. F.: Toxicity of some opium al-kaloids. Acta Pharmacologica et Toxico-logica, 1950, 6:3, 234-49.

E

EMET, A. S.; DALOKAY, H.: Heroinomlarda burun mukozasi infrazinda heroin alkaloidinin aranmasi (Examination of the nasal secretions of heroin addicts for morphine and its derivatives). Türk Tip Cemiyeti Mecmuasi, 1950, 16:5,·214-7.

F

FELDSTEIN, M.; KLENDSHOJ, N. C.; SPRAGUE, A.: 2-Anthraquinone sulfonate derivatives of morphine and codeine. Analytical Chemistry, 1949, 21 (12): 1580,-1581.

FEUDELL, P.: Zur Wirkung der Nebenalkaloide in Opiaten (pavium "forte") (The effect of opiate alkaloids [pavium "forte"]). Therapie der Gegenwart, 1950, 89:4, 128-130.

FINDLAY, S. P.; SMALL, L. F.: Preparation and degradation of 6-methylcodeine. Journal of the American Chemical Society, 1950, 72, 3249-52.

FINDLAY, S. P.; SMALL, L. F.: Preparation and properties of codeinone. Journal of the American Chemical Society, 1950, 72, 3247-9.

FULTON, C. C.: Opium Alkaloids-Codeine. United Nations Economic and Social Council document E/CN.7/117/Add. l, 1948, 2-11.

G

GARCIA-BLANCO, J.; VIA, J.: Contribución al conocimiento de la hipotensión codeínica (Contribution to the knowledge of codeine hypotension). Revista Española de Fisiologia, 1950, 6 (2): 103-107.

GOTO, K.; MICHI, K.: Sinomenine. LIX. Dihydrosinomeninone. Acta Phytochimica (Japan), 1949, 15, 183-5. The dehydration of dihydrosinomeninone and (-+) demethoxydihydrosinomeninol. New oxide ring closures in the dihydrothebainone series. Acta Phytochimica, 1949, 15, 187-91.

H

HARDY, J. D.; CATTRELL, McK.: Measurement of pain threshold-raising action of aspirin, codeine, and meperidine (Demerol). Federation Proceedings, 1950, 9(1): 282.

HAZARD, R.; CORNEC, A.; PIGNARD, P.: Dihydroxycodeinone as an activator of procaine esterase. Comptes Rendus de la Société de Biologie, 1950, 144, 356-8.

HOMEYER, A. H.; CAUGHLAN, J. A.: 6-Methydihydrocodeine. U. S. patent 2,510,732, 6 June 1950.

HOMEYER, A. H.; CAUGHLAN, J. A.: Method of making 6-methyldihydrocodeine, U. S. patent 2,510,732, Application 21 February 1948. Issued 6 June 1950.

L

LIERTZER, V.: Opium Alkaloids. Oesterreichische Apotheker Zeitung. 1950, 4, 273-5.

M

McNALL, F. J.: Determination of ethylmorphine in sirups. Journal of the Association of Official Agricultural Chemists, 1950, 33, 194-5.

MIODONSKI, J.: Eukodal as a diagnostic means in oto-neurology. Acta oto-laryngologica, 1949, 37, 116-23.

P

PFEIFFER, C. C.; LEE, R. E.; HEMMENS, E.: The eosinophil response after dilaudid and acetyl-salicylic acid. Journal of Pharmacology and Experimental Therapeutics, 1950, 98(1):26.

S

SLAUGHTER, D.: Neostigmine and opiate analgesia. Archives Internationales de Pharmacodynamie et de Thérapie, 1950, 83:1, 143:148.

SCHMID, H.; KARRER, P.: Beta-Dihydrothebaine. Helvetica Chimica Acta, 1950, 33, 3-73.

STACEY, R. S.: The Choice of an Opium Derivative. Practitioner, 1950, 164, 182-4.

T

THORN, N.; AGREN, A.: Kuantitativ best?mning av oxidimorfin i morfin (Quantitative determination of oxidimorphine in morphine). Svensk Farmaceutisk Tidskrift, 1949, 53 (2): 17-24; (3): 33-44; (4): 49-55.

W

WHITMORE, F. C.; HOMEYER, A. H.: Method of making alkyldihydrothebainones. U. S. patent 2,510,731; Application 3 May 1946; Issued 6 June 1950.

WHITMORE, F. C.; HOMEYER, A. H.: Alkyldihydrothebainones. U. S. patent 2,510,731, 6 June 1950.

D. Other Drugs and Substances Derived from the Opium Poppy A

ANONYMOUS: Apomorphine treatment for morphine addiction . British Journal of Addiction, 1949, 46, 93-101.

B

BAIZER, M. M.: Purification of papaverine. U.S. patent 2,507,135, 9 May 1950.

BAUMGARTEN, G.; CHRIST,. W.: Ueber das Mohnkapsel-Alkaloid Narkotolin (The poppy-seed capsule alkaloid narcotoline). Pharmazie, 1950, 5, 80-2.

BOSE, A. N.; GHOSH, J. K.: Note on the pharmacological action of cotarnine prepared from Indian opium alkaloid. Indian Journal of Physiology, 1949, 3, 28-30.

C

CHEYMOL, J.; QUINQUAUD, A.: Sur le maintien, en présence d'yohimbine, du pouvoir émetisant de l'apomorphine injectée sous la peau. Comptes Rendus de la Société française de Gynécologie, 1950, 144:5-6, 400-1.

CHEN, G.; ENSOR, C. R.: Influence of diphenylhydramine hydrochloride (benadryl) on apormorphine-induced emesis in dogs. Journal of Pharmacology and Experimental Therapeutics, 1950, 98, 245-50.

F

FULTON, C. C.: Opium Alkaloids-Narceine. United Nations Economic and Social Council document E/CN.7/117, 1948, part II E, 52-60.

FULTON, C. C.: Some Minor Alkaloids of Opium-Alkaloid 1. "Porphyroxine Meconidine". United Nations Economic and Social Council document E/CN.7/117, 1948, part II D, 48-51.

52 J

JAKOBEY, I.: Poppy as a source of lecithin. Agr?rtudom?nyilszemie, 1949, 45-6.

JAQUES, A.: Clinical Uses of Papaverine hydrochloride. Current Researches in Anesthesia and Analgesia, 1950, 29, 22-28.

K

KANEVSKAYA, S. I.; SEMENOV, V. A.: Opianic acid as a source of veratraldehyde. Meditsinskara promyshlennost SSSR, 1949, 6, 16-18.

KEENAN, G. L.: Microscopy of some important alkaloids, II. Chemist-Analyst, 1950, 39, 52-6.

KYSER, F. A.; TRUMP, R.: The effect of papaverine upon the cardiotoxic lesions of digitalis in the dog. American Heart Journal, 1948, 36, 133-4.

M

MANSKE, R. H. F.: Alkaloids of fumariaceous plants, XLIV, Corydales incisa and the constitutions of adlumine and capnoidine. Journal of the American Chemical Society, 1950, 72, 3207-8.

MASON, M. M.: Apomorphine in dogs. Journal of the American Veterinary Medical Association, 1950, 117:882, 217-9.

MEIER, R.; TRIPOD, J.: Beziehung zwischen papaverinartigen und autonomen Wirkungen (Relation between papaverine-like and autonomi actions). Helvetica Physiologica et Pharmacologica Acta, 1950, 8, 137-45.

MERCIER, F.; MERCIER, J.; SESTIER, M. R.: Note préliminaire sur I'action spasmolytique expérimentale de quelques dérivés carboxylés de la papavérine et de la dihydropapavérine. Comptes Rendus de la Société de Biologie, 1949, 143, 112, 92-94.

MORSIER, G. de; FELDMANN, H.: Le traitement biologique de l'alcoolisme chronique par l'apomorphine, étude de 150 cas. Schweizerische Medizinische Wochenschrift, 1950, 80, 18, 465-467.

MURPHY, R. A., Jr.; CROWLEY, L. G.: The effect of Priscoline, papaverine, and nicotinic acid on blood flow in the lower extremity of man. A comparative study. Surgery, 1950, 27, 655-63.

Q

QUEVAUVILLER, A.: Toxicité et·action antispasmodique comparées de quelques dérivés de la papavérine. Anesthésie, 1949, 310-22.

QUEVAUVILLER, A.; GARCET, S.: Pouvoir anesthésique local de quelques dérivés dihydrogenes et bromes de la papavérine. Comptes Rendus de la Société de Biologie, 1950, 144, 165-7.

R

RONQUES, L.: Traitement de l'alcoolisme chronique par l'apomorphine. Presse médicale, 1949, 57, 1181.

S

SCHOFF, C.: Konstitution und Bildungsmechanismus des Pavins (Constitution and mechanism of formation of pavine). Experientia, 1949, 5, 201-2.

SKINNER, B.: The Isomerization of berberine and cotarnine bases in presence of alkali. Journal of the Chemical Society, 1950, 823-7.

T

TAYLOR, E. B.: Oxidation of papaverin by selenium dioxide. Journal of Pharmacy and Pharmacology, 1950, 2, 324-5.

W

WINDER, C. V.; THOMAS, R. W.; RAMM, O.: Relative experimental coronary vasodilator potencies of papaverine and its ethyl analog, ethaverine (diquinol, perparine). Journal of Pharmacology and Experimental Therapeutics, 1950, 100: 4 part I, 482-8.

Part III THE COCA LEAF AND DRUGS MANUFACTURED THEREFROM A

AAMON, A.; SAVELSBERG, W.: Die enzymatische Spaltung von Atropin, Cocain und chemisch verwandten Estern (The enzymic hydrolysis of atropine, cocaine, and chemically related esters). Zeitschrift für Physiologic und chemie, 1949, 284, 135-56.

F

FELDBERG, W.; LIN, R. C. Y.: The effect of cocaine on the acetylcholine output of the intestinal wall. Journal of Physiology, 1949, 109, 475-87.

FISCHER, R.; BUCHEGGER, E.: Zur adsorptionsanalytischen Bestimmung von Cocain-Novocain-Gemischen (Adsorption-analytical determination of cocaine-procaine mixture). Pharmazeutische Zentralhalle, 1950, 89, 185-6.

FROMMEL, E.; FAVRE, M.; VALLETTE, F.: De la prépondérance de l'action anti-adrénalinique sur l'effet anti-acétylcholinique des anesthésiques locaux (cocaine, novocaine et percaine). Archives Internationales de Pharmacodynamie et de Thérapie, 1948, 76(3), 341-350.

G

GUAGNINI, O. A.; VONESCH, E. E.: Identificación de pequeñas cantidades de cocaíne en presencia de procaína y otros anestésicos amino-benzoicos (Identification of small quantities of cocaine in the presence of procaine and other aminobenzoic anesthetics). Archivos de farmacia y de bioquimia, 1949, 4, 269-71.

GUTIERREZ-NORIEGA, C.: Inhibition of the central nervous system produced by chronic cocaine intoxication . Federation Proceedings, 1950, 9(1): 280.

GUTIERREZ-NORIEGA, C.: Ueber den Cocaismus in Südamerika (Cocaism in South America). Pharmazie, 1950, 5:7, 317-320.

GUTIERREZ-NORIEGA, C.; HAGEN, A. W. von: The strange case of the coca leaf. Scientific Monthly, 1950, 70, 81-9.

H

HAAS, H.: Ueber die Beeinflussung der Senföl-und Crotonölentzndung durch Cocain (Effect of cocain in inflammation due to mustard oil and croton oil). Klinische Wochenschrift, 1950, 28:17-18, 306-8.

HWANG, T.-F.: The inhibitory effects of creatine, creatinine, sodium moniodate and cocaine on the regeneration of visual purple. Japanese Journal of Physiology, 1950, 1, 69-74.

L

LEVY, J.; ZISSMANN, E.: Détermination de faibles quantités de cocaïne en présence d'ecgonine. Journal de physiologie, 1950, 42.

M

MARSH,. D. F.; VAN LIERE, Edward J.: Effect of cocaine and ephedrine on the vasoconstriction produced by acute oxygen lack. Archives Internationales de Pharmacodynamie et de.Thérapie, 1950, 81, 207-210.

N

NORPOTH, H.: Ueber Todesfälle nach Anästhesie mit Kokainersatzmitteln (Deaths following anesthesia with cocaine substitutes). Aerztliche Wochenschrift, 1950, 5:22, 369-372.

R

RATHENASINKAM, E.: Color test for cocaine. Analyst, 1950, 75, 169.

S

SCHEIE, H. G.; OJERS, G. W.: The effect of procaine and cocaine when applied locally to the iris. American Journal of Ophthalmology, 1950, 33:10, 1543-51.

STEINHAUS, John E.: Cardiovascular aspects of acute cocaine intoxication. Federation Proceedings, 1950, 9, 318.

STEINHAUS, J. E.; TATUM, A. L.: An experimental study of cocain intoxication and its treatment. Journal of Pharmacology and Experimental Therapeutics, 1950, 100, 351-61.

53 Part IV CANNABIS AND ITS DERIVATIVES

ADAMS, Roger: Dibenzopyran marihuana-like compounds. U. S. patent 2,509,386, 30 May 1950. U.S. patent 2,509,387, 30 May 1950.

AVISON, A. W. D.; MORRISON, A. L.; PARKES, M. W.: Tetrahydrodibenzopyran derivatives isomeric with tetrahydrocannabinols.

Journal of the Chemical Society, 1949 (4), 952-955.

GRIEBEL, C,: Marihuana. Pharmaceutische Zeitung, 1950, 86, 424-8.

GUILLY, P.: Le club des Hachischins. Encéphale, 1950, 39:2, 175-185.

PARKER; STANSFIELD; WRIGLEY, F.: Synthetic Cannabis Preparations in Psychiatry. (1) Synthexyl. Journal of Mental Science, 1950, XCVI, 402, 276-279.

PARREIRAS, Decio: Canabismo o Maconhismo (Estudos Brasileiros) (Addiction to Cannabis or maconha) (Brazilian Studies). Imprensa Médica, 1949, 430, 34-64.

Part V SYNTHETIC DRUGS A. General Works A

ADAMSON, D W.; GREEN, A. F.: A new series of Analgesics. Nature 1950, 165, 122.

B

BECKETT, A. H.; LINNELL, W. H.: Synthetic analgesics I. Journal of Pharmacology, 1950, 2, 418-26. de BOER, B.; FOSTER, R. H. K.: Respiratory depression in rabbits following administration of NU-2206, morphine sulfate, and piperidine analgesics. Journal of pharmacology and Experimental Thera-peutics, 1950, 98(1) F 6.

BROTMAN, M.; CULLEN, S. C.: In travenous supplementation during nitrous oxide anesthesia II. Comparison of morphine, meperidine, and a new potene analgesic (NU-2206) with the application of multiple covariance analysis. Journal of Pharmacology and Experimental Therapeu-tics, 1950, 98 (1): 4.

BROWN, D. J.; COOK, A. H.; HEILBRON, I.: The preparation of potential analgesic compounds I, II, and III. Journal of the Chemical Society, 1949 (Suppl. 1), S106-S126.

BROWN, J. M.; VOLPITTO, P. P.: Clinical impressions of some of the newer analgesic agents. Journal of the Medical Association of Georgia, 1950, 39(2) 63-66.

C

CHEN. K. K.: Newer synthetic analgesics . Medical Clinics of North America, 1950, 34, 369-78.

F

FARMILO, C. G.; ROSS, A. S.; BERRY , S.; KENNETT, P. M. L.: Microchemical Identification of Synthetic Narcotics. Bulletin on Narcotics, vol. II, no 2, 1950, 21-31.

FRENCH, F. A.: Experimental evaluation of synthetic drugs. Annals of the New York Academy of Science, 1949, 52, 729-41.

G

GRUBER, C. M. Jr.; LEE, K. S.; GRUBER C. M.: A comparison of the actions of meperidine, NU-1196, methadone, morphine, NU-2206, and metopon upon the intestine and uterus. Journal of Phar-macology and Experimental Therapeutics, 1950, 99:3, 317-24.

H

HOUDE, R. W.; SEEVERS, M. H.; PURCELL, F.; IRWIN, S.: Effects of morphine, meperidine, and methadon on the reflex reaction times of spinal animals. Journal of Pharmacology and Experimental Therapeutics, 1950, 98(1) : 14.

K

KLENTON, J. E.; BEECHER, H. K.: New analgesics. Journal of the American Medical, Association, 1949, 1051, 1146.

L

LUDUENA, F. P.; ANANENKO, E.: Les effets pharmacodynamiques de certains analgésiques nouveaux. Archives In-ternationales de Pharmacodynamie et de Thérapie. 1950, 81, 259-75.

M

MASLENNIKOVA, V. A.; LAZUR'-EVSKII, V.: Synthesis from cotarnine Diklady Akadema Nauk, 1950, 72, 305-6.

MORRISON, A. L.; RINDERKNECHT,

H.: Synthetic analgesics, X, Tertiary carbinols and derivatives from Mannich bases. Journal of the Chemical Society, 1950(6): 1510-1513.

P

PFEIFFER, C. C.: Historical aspects of synthetic drugs. Modern Hospital, 1950; 75.:6, 98-102.

S

SANTARATO, R.; LENARDON, B.: Azioni anzimatiche della morfina e dei morfinosimili di sintesi. I. Respirazione dei tessuti nervoso centrale, epatico e muscolare di topi bianchi intossicati acutamente e cronicamente con morfina, amidone dolantina (Enzymatic action of morphine and synthetic morphine substitutes I. Respiration of central nervous, hepatic and muscular tissue of white mice acutely and chronically intoxicated with morphine, amidone and dolantin). Acta Anaesthesiologica, 1950. 1:4. 338-44.

SLAUGHTER, D.: Studied on synthetic analgesics in humans. Current Researches on Anesthesia and Analgesia. 1950. 29-34-8.

SOEHRING, K.: Neuere synthetische Arzneimittel mit zentralanalgetischer Wirkung (New synthetic analgesics with effect upon the central nervous system). Medizinische Klinic. 1950, 45:27, 817-22

W

WILLIAMS, E. M. V.; STREETEN, D. H. P.: The action of morphine, pethidine, and amidone upon the intestinal motility of conscious dogs. British Journal of Pharmacology, 1950, 5, 584-603.

WILSON, W.: Synthetic analgesics and related compounds. I. Amidines and 4:5-dihydroglyoxalines. Journal of the Chemical Society, 1950, 1950(8): 2173-2176.

Z

ZOBOLI, P.; MAGGIORE, L.: Iperglicemia da sostanza morfinosimili: recerche sperimentali (Hyperglycemia due to morphine substitutes; experimental research). Giornale italiano di Anestesiologia, 1950, 16:1, 34-37.

54 B. Pethidine and Related Compounds A

AVISON, A. W. D.; MORRISON, A. L.: Synthetic analgesics, VI. The synthesis of ketobemidone. Journal of the Chemical Society, 1950(6): 1469-1471.

AVISON, A. W. D.; MORRISON, A. L.: Synthetic analgesics. VIII. Further attempts to prepare 3-phenylpiperidine derivatives. Journal of the Chemical Society, 1950(6) :1474-1477

B

BERNSTEIN, A.: Klinische Erfahrungen mit Cliradon, einem neuen synthetischen Analgeticum (Clinical experiences with Cliradon, a new synthetic analgesic). Schiveizeriche medizinische Wochenschrift, 1949, 79(48), 1159-1162.

BROTMAN, M,; CULLEN, S. C.; WILKINS, D : Intravenous supplementation during nitrous oxide anesthesia: comparison of demerol, morphine and a new potent analgesic) drug (15431). Anesthesiology, 1950, 11:5, 527-37.

G

GRIEBEL, C.: Microchemical identification of dolantin. Pharmazeutische Zeitung, 1949, 85, 757-8.

GRIFFITHS, H. F.: Pethidine as an adjunct to nitrous oxide and oxygen anaesthesia. British Medical Journal, 1950, 2:4682, 763-4.

GROSS, E. G.; HOLLAND, H. L.; SCHUELER, F. W.: Human studies on analgesic piperidine derivatives. Journal of Applied Physiology, 1948, 1, 298-303.

GROSS, F.; MEIER, R.: 1-Methyl-4-moxyphenenyl-piperidin-4ethyl keton (Cliradon) ein neues synthetisches Analgeticum mit morphiahnlicher Wirkung (1-methyl-4/in-oxyphenyl-piperidine-4-ethyl ketone (Cliradon) a new synthetic analgesic with morphine-like action). Schweizerische medizinische Wochenschirift, 1949, 79(48) : 1154-1159.

CRUBER, C. M., Jr.; LEE, Kwang Soo; GRUBER, C. M.: A comparison of the actions of meperidine, dl-alpha-l,3-dimethyl-4-phenyl-4-propionyloxypiperidine hydro-methylmorphinan (NU-2206, dromoran), and metopon on the intestine and uterus. Journal of Pharmacology and Experimental. Therapeutics, 1950, 99, 317-24.

GRUBER, C. M., Jr.; LEE, Kwang Soo; GRUBER, C. M.: Pharmacology and toxicology of dl-alpha-l, 3-dimethyl-4-phenyl-4-propionyloxypiperidine hydrochloride (NU-1196, nisenil). Journal of Pharmacology and Experimental Therapeutics, 1950, 99, 312-16.

H

HARDY, J. D.; CATTELL, McK.: Measurement of pain threshold-raising action of aspirin, codeine, and meperidine (Demerol). Federation Proceedings, 1950, 9(1): 282.

HOLCK, Harold; G. O.; KIMURA, Kazuro, K.; KIMURA, T. E. Comparison of analgetic activity of sixty-seven aryl-alkamines with that of morphine and meperidine by the mouse hot-plate method. Journal of the American Pharmaceutical Association, 1950, 39, 354-9.

HUGHES, J. G.; HILL, F. S.; GREEN, C. R.; DAVIS, B. C.: Electroencephalography of the newborn. V. Brain potentials of babies born of mothers given meperidine hydrochloride (demerol hydrochloride), vinobarbital sodium (delvinal sodium) or morphine. American Journal of Diseases of Children, 1950, 79:6, 998-1007.

HUGUENARD, R.: L'association diparcol-dolosal-anesthesie locale. Anesthesie et Analgesie, 1950, 7:4; 569-570.

I

ISBELL, H.: The addiction liability of some derivatives of meperidine, Journal of Pharmacy and Experimental Therapeutics, 1949, 97, 182-9.

K

KAGI, H.; MIESCHER, K.: Ueber eine neue Synthese morphinahnlichwirkender 4-Phenyl-piperidin-4-alkylketone and verwandter Verbindungen (A new synthesis of 4-phenyl-piperidine-4-alkyl-ketone and related compounds). Helvetica Chimica Acta, 1949, 32(7) : 2489-2507.

L

LORENZINI, L.: Ricerche clinico-sperimentali sul cliradon (cloridrato dell 1-metil-4-(m. ossi-fenil)-piperidin-4-etilche-tone) nuovo prodotto analgesico di sintesi (Clinico-experimental research on cliradon (1-methyl-4- (m-hydroxyphenyl)-4-piperidyl ethyl ketone hydrochloride) new synthetic analgesic product. Acta Anaesthesiologica, 1950, I:4, 316-37.

M

MORRISON, A. L.; RINDERKNECHT, H.: Synthetic analgesics. V. Compounds related to pethidine. Journal of the Chemical Society, 1950, 1467-9. VI. The synthesis of ketobemidon. Journal of the Chemical Society, 1950, 1469-71. VII. Metadine and related 3-phenylpiperidine derivatives. Journal of the Chemical Society, 1950, 1471-4. VIII Further attempts to prepare 3-phenyl-piperidine derivatives. Journal of the Chemical Society, 1950, 1474-7.

MUSHIN, W. W.; RENDELL-BAKER, L.: Intravenous pethidine and flaxedil in anesthesia for thoracic operations. British Journal of Anaesthesia, 1950, 22:4, 235-9.

N

NICKERSON, M.: Analgesic effects of nitrous oxide and meperidine, alone and combined with amphetamine. American Journal of Medicine, 1950, 8:4, 541.

R

RODRIGUEZ MIRANDA, J. V.: Asinergia funcional uterina y demerol (Uterine functional asynergy and demerol). Dia Médico, 1950, 22:64, 2720-1.

S

SLAVIN, M. I.: Demerol premedication in the ambulatory patient. Oral Surgery, Oral Medicine and Oral Pathology, 1950, 3:9, 1159-67.

T

THELEN, C.: Nisentil, a new analgesic drug for use in obstetrics; a preliminary report. Jackson Clinic Bulletin, 1949, 11, 170-2.

C. Methadone and Related Compounds A

ADLER, T. K.; EISENBRANDT, L. L.: The initial uptake of C 14-labelled methadone by rat tissues. Proceedings of the Society of Experimental Biology and Medicine, 1949, 72(2) : 347-349.

ATANAKOVIC, D.; De JONGH, D. K.: Action of. methadone on blood-pressure-regulating mechanisms. Archives Interna-tionales de Pharmacodynamie et de Thé-rapie, 1950, 82, 494-9.

B

BAUMHOFF, G.; SCHUERMEYER, A.: Polamidon als Spasmolyticum und Analgeticum (Polamidon as a spasmolytic and analgesic). Medizinische Klinik, 1950, 45, 16, 489-494.

BEESE, F. W.: Kasuistik: gibt es einePolamidon-Sucht? (Is there an addiction to Polamidon?). Aerztliche Wochenschrift, 1950, 5:30, 558-559.

BOYD, E. M.; BUELL, M.: Methadone and respiratory tract fluid. Canadian Medical Association Journal, 1950, 63:6, 588-90.

C

CRONHEIM, G.; EHRLICH, L.: The combined used of pentobarbital sodium and methadone hydrochloride for anesthesia in dogs. Journal of the American Veterinary Medical Association, 1950, 116:880, 41-42.

E

EDDY, N. B.; TOUCHBERRY, C. F.; LIEBERMAN, J. E.: Synthetic analgesics. I. Methadone isomers and derivatives. Journal of Pharmacology and Experimental Therapeutics, 1950, 98(2): 121-137.

EISENBRANDT, L. L.; ADLER, T. K.; ELLIOTT, H. W.; ABDOU, I. A.: The role of the gastro-intestinal tract in the excretion of C 14-1abelled methadone by rats. Journal of Pharmacology and Experimental Therapeutics, 1950, 98(2): 200-205.

ELLIOTT, H. W.; SUTHERLAND, V. C.: Influence of methadone on oxygen uptake and glycogenolysis of rat liver slices. Proceedings of the Society for Experimental Biology and Medicine, 1950, 75:1, 242-4.

F

FABER, J. S.: Colorimetrische bepaling van methadon (Colorimetric determination of methadon). Pharmaceutisch Weekblad, 1950, 85:39-40, 719-23.

FULTON, C. C.: The Identification of Methadon by Microcrystals. United Nations Economic and Social Council document E/CN.7/117, 1948, part II B, 17-31.

G

GAENSLER, E. A.; McGOWAN, J. M.: Biliary and small intestinal spasm due to synthetic analgesics methadone and methyldihydromorphinone (metopon). Gastroenterology, 1950, 16:2, 484-9.

GOECK, P.: Polamidon in der Chirurgie (Polamidon in surgery). Medizinische Klinik, 1950, 45:22, 710.

GRIEBEL, C.: Microchemical iden-tification of polamidon. Pharmazeutische Zeitung, 1950, 86, 540-1.

H

HAUSSLER, A.: Nachweise des Polamidon (qualitative and quantitative determination of polamidon). Süddeutsche Apotheker Zeitung, 1950, 90, 423-4.

HUBACH, C. E.; JONES, F. T.: Methadone hydrochloride. Analytical Chemistry, 1950, 22, 595-8.

K

KEATS, A. S.; BEECHER, H. K.: Clinical evaluation of two new analgesics, heptazone and WIN 1161-2 as a test of a new method of measuring analgesic power. Federation Proceedings, 1950, 9(1): 290.

L

LEIMDORFER, A.: An electroencephalographic analysis of the action of amidone, morphine and strychnine on the central nervous system. Archives Internationales de Pharmacodynamie et de Thérapie, 1948, 76(2): 153-162.

M

MAIER, S.: Ueber Polamidonmiss-brauch (Abuse of Polamidon). Medizinische Monatsschrift, 1950, 4:8, 620-1.

MARCH, C. H.; GORDAN, G. S.; WAY, E. L.: The effect of castration and of testosterone on the action and distribution of de-methadone in the rat. Archives Internationales de Pharmacodynamie et de Thérapie, 1950, 82:2, 270-276.

MORRISON, A. L.; RINDERKNECHT, H.: Synthesis of compounds related to amidone. Journal of the Chemical Society, 1950, 1478-81.

O

OFNER, P.; WALTON, E.; GREEN, A. F.; WHITE, A. C.: New Analgesics IV. Variations in the basic sidechain of amidone.. Some pharmacological results. Journal of the Chemical Society, 1950, 2158-66.

P

POPKIN, R. J.: Experiences with a new synthetic analgesic, amidone: its action on ischemic pains of occlusive arterial diseases. American Heart Journal, 1948, 35, 793-9.

R

REMY, D.: Ueber den Einfluss des Polamidon (Hoechst 10820) auf die Ventilationssteigerung nach CO 2Atmung (Effect of Polamidon [Hoechst 10820] in increasing pulmonary ventilation following administration of carbon dioxide). Klinische Wochenschrift, 1950, 28:17-18, 318-19.

RICKARDS, J. C.; BOXER, G. E.; SMITH, C. C.: Studies on the distribution and metabolism of Methadone in normal and tolerant rats by a new colorimetric method. Journal of Pharmacology and Experimental Therapeutics, 1950, 98(4): 380-391.

RIEBELING, C.: Bemerkungen zur Polamidontherapie (Observations on polamidon therapy). Deutsche Medizinische Wochenschrift, 1950, 75:27-8, 946-8.

S

SATTES, H.: Ueber Polamidonsucht (Polamidon addiction). Deutsche Medizinische Wochenschrift, 1950, 75:19, 638-641.

SCHWAIGER, M.; BACH, R.: Das neue Analgeticum Polamidon (Hoechst 10820) (The new analgesic Polamidone). Klinische Wochenschrift, 1949, 27(21-22): 375-379.

SHAPIRO, D.: Some derivatives of amidone. Journal of Organic Chemistry, 1949, 14(5): 839-848.

SUNG, Chen-Yu; WAY, E. L.: The effect of the liver on the metabolism of D,L-methadone in vitro and in vivo. The Journal of Pharmacology and Experimental Therapeutics. 1950, 98, 72-76.

SUPNIEWSKI, J.; VENULET, J.: Pharmacological properties of a new amidone derivative. Polska Akademia Umiejetnosci, .Wydzial Lekarsk Rozprawy, 1949, 10:8, 30.

T

TEWES, H.; RUBRECHT, H.: Polamidon-Missbrauch (Misuse of Polamidon). Münchener Medizinische Wochenschrift, 1950, 92:19-20, 786-7.

W

WATTS, D. T.: The effect of methadone isomers on the respiration of rat brain homogenates. Archives of Biochemistry, 1950, 25(1): 201-207.

WATTS, D. T.: Effect of D- and L-methadone on blood glucose and lactate of dog. Federation Proceedings, 1950, 9, 323-324.

WAY, Elong, E.; SIGNOROTTI, Betty T.; MARCH, Cyril, H.: Countercurrent studies on excreta after D, L-methadone administration. Journal of Pharmacology and Experimental Therapeutics, 1950, 98 (1): 34.

WEISS, P.; CORDASCO, M.; REINER, L.: Chloro Analogs of Methadon. Journal of the American Chemical Society, 1949, 71, 2650-2.

WINKLER, A.; ALTSCHUL, S.: Effects of methadone and morphine on the electroencephalogram of the dog. Journal of Pharmacology and Experimental Therapeutics, 1950, 98, 4, I, 437-446.

WINTER, C. A.; FLATAKER, L.: Studies on Heptazone (6-morpholino-4, 4-diphenyl-3-heptanone hydrochloride) in comparison with other analgesic drugs. Journal of Pharmacology and Experimental Therapeutics, 1950, 98, 305-17.

56 D. Morphinan and Morphine Synthesis C

CURRERI, A. R.; GALE, J. W.; DICKIE, H. A.: Effectiveness of dromoran (3-hydroxy-n-methyl morphinan) as an analgesic in thoracic surgery. Journal of Thoracic surgery, 1950, 20:1, 90-96.

F

FISCHER, H.: Ueber vollsynthetische Analgetica mit morphinähnlicher Wirkung (Synthetic analgesics with morphine-like action). Aerztliche Monatsschrift, 1949, 5, 231-46.

FRASER, H. F.; FLANARY, H. G.; HOUDE, R. W.; ISBELL, H.: Addiction liabilities of some drugs in the morphine series. Federation Proceedings, 1950, 9(1): 273.

FRASER, H. F.; ISBELL, H.: Addiction Liabilities of Morphinan, 6-Methyldihydro-morphine and Dihydrocodeinone. Journal of Pharmacology and Experimental Therapeutics, 1950, 100(2): 128-135.

G

GATES, M.: The synthesis of ring systems related to morphine. III. 5,6-Dimethoxy-4-cyanomethyl-1, 2-naphto-quinone and its condensation with dienes. Journal of the American Chemical Society, 1950, 72, 228-34.

GATES, M., TSCHUDI, G.: Synthesis of racemic B- 5-dihydrodesoxycodeine methyl ether. Journal of the American Chemical Society, 1950, 72, 4839-40.

GATES, M.; WOODWARD, R. B.; NEWHALL, W. F.; KUNZLI, R.: Synthesis of ring systems related to morphine. IV. N-methylisomorphinane. Journal of the American Chemical Society, 1950, 72, 114-6.

GINSBURG, D.: The synthesis of morphan (2-azabicyclo [3.3.1] nonane). Journal of Organic Chemistry, 1950, 15, 1003-5.

GROSS, E. G.; FEATHERSONE, R. M.: Studies on some smooth muscle effects of 3-hydroxy-N-methylmorphinan hydro-bromide (NU-2206). Federation Proceed-ings, 1950, 9, 279.

GRUBER, C. M., Jr.; LEE, K. S.; GRUBER, C. M.: Studies on the pharmacology and toxicology of di-δ-1,3 dimethyl-4-propionoxy piperidine (NU-1196). Journal of Pharmacology and Experimental Therapeutics, 1950, 99:3, 312-6.

H

HOFFMAN-LA ROCHE & CO.: Morphine substitute. Swiss patent 254106, 1 December 1948.

HUGGINS, R. A.; GLASS, W. G.; BRYAN, A. R.: Protective action of Nallyl-normorphine against respiratory depression produced by some compounds related tomorphine. Proceedings of the Society of Experimental Biology and Medicine, 1950, 72(2): 540-541.

J

JAGGARD, R. S.; ZAGER, L. L.; WILKINS, D.S.: Clinical evaluation of analgesic drugs; A comparison of NU-2206 and Morphine sulfate administered to post-operative patients. American Medical As-sociation, Archives of Surgery, 1950, 61:6, 1073-82.

L

LEE, R. E.; HASEGAWA, A. K.: Human analgesic testing of experimental drugs Nisentil (NU-1196) and NU-2206. Journal of Pharmacology and Experimental Therapeutics, 1950, 98(1): 2021.

M

MERCIER, F.; LESPAGNOL, A.; MERCIER, J.: Experimental antispasmodic activity of some synthetic substitutes for morphine. Comptes Rendus de la Société de Biologic, 1949, 143, 1123-5.

MONDON, A.: The development of morphine synthesis. Chemische Zeitung, 1950, 74, 314-16.

N

NEISSER, K.: Sintesi di sostanza morfino-simili (Synthesis of morphine-like drugs). Farmaco, Scienza e Tecnica, 1950, 5:2, 169-182.

R

RANDALL, L. O.; LEHMANN, G.: Analgesic action of 3-hydroxy-N-methyl morphinan hydrobromide (NU-2206). Federation Proceedings, 1950, 9(1): 217.

RANDALL, L.- O.; LEHMANN, G.: Analgesic action of 3-hydroxy-N-methyl morphinan hydrobromide (dromoran). Journal of Pharmacology and Experimental Therapeutics, 1950, 99:2, 163-170.

RAPAPORT, H.; NAUMANN, R.; BISSELL, E. R.; BONNER, R. M.: The preparation of some dihydro ketones in the morphine series by Oppenauer oxidation. Journal of Organic Chemistry, 1950, 15, 1103-7.

RAPAPORT, H.; PAYNE, G. B.: Stereochemical studies in the morphine series. The relative configuration at carbons five and six. Journal of Organic Chemistry, 1950, 15, 1093-1102.

S

SCHLITTLER, E.; LINDEMANN, A.: Ueber Aporphinalkalide, II. Ueber die Synthese von 10-Oxo-aporphinen (Aporphine Alkaloids, II, The Synthesis of 10-oxo-aporphines). Helvetica Chimica Acta, 1949, 32, 1880-91.

SCHNIDER, O.; HELLERBACH, J.: Synthese von Morphinanen. II. (Synthesis of morphinanes. II). Helvetica Chimica Acta, 1950, 33(6): 1437-1448.

SCHROCKSNADEL, H.; WALTINGER, K.: Die Eupaverinewirkung auf den Blutdruck beim Menschen (Effect of eupaverine on blood pressure in man). Zeitung für Kreislaufforschung, 1948, 37, 233-9.

SIEGEL, B. M.; BLOCH, D. P.; PITESKY, L; LAST, J. H.: Comparative study of morphine and dromoran as antidiuretic agents in the dog. Proceedings of the Society for Experimental Biology and Medicine, 1950, 74:4, 809-12.

SMITH, R. M.: Clinical experience with dromoran hydrobromide (NU-2206) for the relief of chronic pain . Southern Medicine and Surgery, 1950, 112:8, 251-2.

SOFFER, M. D.; STEWART, R. A.; CAVAGNOL, J. C.; GELLERSON, H. E.; BOWLER, E. A.: Syntheses in the direction of morphine. II. Some intermediates and model compounds. Journal of the American Chemical Society, 1950, 72, 3704-9.

SUGASAWA, S.: Total synthesis of tetrahydrodesoxycodeine. Kagaku no Ry?iki, 1950, 4, 353-7.

T

THEYE, R. A.; TOELTING V. K.; GRAF, J. P.: The use of NU-2206 (3-hydroxy-N-methyl-morphinan) for pre-oper-ative medication. Journal of Pharmacology and Experimental Therapeutics, 1950, 98(1).

TIDRICK, R. T.; ZAGER, L. L.; EASTWOOD, D. W.; WILKINS, D. S.; JAGGARD, R. S.: Control comparison of NU-2206 (3-hydroxy - N - methyl - morphinan hydrobromide) with morphine sulfate for relief of postoperative pain. Journal of Laboratory and Clinical Medicine, 1949, 34(12): 1758-1759.

TSATSAS, G.: Synthese de quelques homologues de la papavérine. Bulletin de la Société de Chimie de France, - 1949, 884-90.

TSATSAS, G.: Nouveaux homologues de la papavérine. Comptes Rendus de la Société de Biologie, 1949, 229, 218-20.

W

WAHL, H.; Société Sempa: La Synthese industrielle de la papavérine. Bulletin de la Société de Chimie de France, 1950, 680-2.

Z

ZAGER, L. L.; SAWTELLE, W. W.; GROSS, E.G.; NAGYFY, S. F.; TIDRICK, R. T.: Observation on the use of a new analgesic, NU-2206 (3-hydroxy-N-methyl-morphinan hydrobromide). Journal of Laboratory and Clinical Medicine, 1949, 34(11): 1530-37.

57 E. Other Synthetic Drugs A

AVISON, A. W. D.; MORRISON, A. L.: Synthetic analgesics. VII. Metadine and related 3 - phenylpiperidine derivatives. Journal of the Chemical Society, 1950(6): 1471-1474.

B

BRAMMER, A.: Ueber unsere Erfahrungen mit "Paldrin Berger", einem neuen Narkotikum (Author's experience with Berger's paldrin, a new narcotic). Deutsches Gesundheitswesen, 1950, 5:46, 1457-8.

BEAUDET, C.: Quelques dérivés nouveaux du Diphényl 1.3. Amino. 2 Propane. Archives Internationales de Pharmacodynamie et de Thérapie. 1950, LXXXI, 1, 11-13.

G

GAYRAL; COMBES: Toxicomanie parphényl-l-amino-2-propane (ortedrine et maxiton). Toulouse médical, 1950, 5l, 4, 218-220.

GOODSON, L. H.; MOFFET, R. B.: N-Allyl-l,2-diphenyl-ethylamine (assignors to George A. Breon and Co.,), Kansas City, Mo. U. S: patent 2,504,122, 18 April 1950.

H

HEUYER, G.; LEBOVICI, S.: Une nouvelle toxicomanie, le maxiton; à propos de deux observations. Annales médico-psychologiques, 1950, 108:2:3, 253-4.

L

LOEWENHARDT, F.: Irgapyrin "Geigy", ein neues Antirheumatikum and Analgetikum as der Pyrazolreihe (Irgapurin "Geigy", a new pyrazolic antirheumatic and analgesic). Deutsche Medizinische Wochenschrift, 1950, 75:14, 459-60.

M

McPHEE, W. D.: Hydroxylated alpha, beta - diphenyl - beta - hydroxy - ethylamines and the preparation thereof. U. S. patent 2,505,645, 25 April 1950.

MORRISON, A. L.; RINDERKNECHT, H.: Tertiary carbinols and derivatives from Mannich bases. Journal of the Chemical Society, 1950, 1510-13.

N

NOLIE, C. R.; AZIMA, M.: The synthesis of a pyridyl analog of papaverine. Journal of the American Chemical Society, 1950, 72, 17-19.

NONAS, G.: Clinical applications of analgesic and sedative action of subdamine. New York State Journal of Medicine, 1950, 50:10, 1257-59.

R

RAPP, G. W.: Diethyl aminoethanol as an analgetic agent. Journal of Dental Research, 1949, 28(6): 676.

S

SBOROV, V. M.; BLUEMLE JR., L. W.: Tetraethylammonium Chloride in pa?n. United States Armed Forces Medical Journal, 1950, 1, 5, 546-9.

Part VI ADDICTION TO NARCOTIC DRUGS A

ABOOD, L. G.; KUN, E.: Studies on the glycogenesis in chronically and acutely morphinized rats. Journal of Pharmacology and Experimental Therapeutics, 1950, 98(1): 1.

ANONYMOUS: Apomorphine treatment for morphine addiction. British Journal of Addiction, 1949, 46, 93-101.

B

BAUMM, H.: Zur Behandlung der Morphinisten (Treatment of morphinism). Deutsches Gesundheitswesen, 1950, 5:44, 1393-7.

BEESE, F. W.: Kasuistik: gibt es eina Polamidon-Sucht? (Is there a polamidon addiction?). Aerztliche Wochenschrift, 1950, 5:30, 558-559.

C

CANCADO, A. L.: Toxicomanias de substituicao (Substituted Drug Addiction). Medica, 1950, 26:438, 71-2.

CATALANO-NOBILI, C.:Terapia delle tossicomanie; metodi moderni di disintossicazione e di disassuefazione nelle intossicazioni croniche di tipo voluttuario (Treatment of toxicomania; modern methods of disintoxication and deprivation in chronic addiction of euphoric type). Rassegna di Neuropsichiatria, 1950, 4:4, 283-350.

CHILD, G. P.; CLARE, F.; FARREL, J.: Use of intravenous ethanol in treatment of a case of opiate addiction, and other experimental therapeutic tests with intravenous ethanol in humans. Federation Proceedings, 1950, 9(1): 22-23.

CHOPRA, R N.: The problem of drug addiction in India. Calcutta Medical Journal, 1950, 47:6, 175-7.

CHOPRA, R. N.: The problem of drug addiction in India. Calcutta Medical Journal, 1950, 47:7, 207-13.

D

DEROBERT, LE BRETON, MICHON, HAFFAR: Recherches expérimentales et cliniques sur certaines modifications biologiques survenant au cours des intoxications chroniques par l'héroïne. Annales de médicine légale, 1950, 30:4, 232-3.

E

EMET, A. S.; DALOKAY, H.: Heroinomlarda burun mukozasi ifrazinda heroin alkaloidinin aranmasi (Examination of the nasal secretions of heroin addicts for morphine and its derivatives). Türk Tip Cemiyeti Mecmuasi, 1950, 16:5, 214-7.

F

F. H.: Traitement du morphinisme par l'électro-choc. Journal des Praticiens, 1950, 64:33, 398.

FRASER, H. F.; FLANARY, H.G.; HOUDE, R. W.; ISBELL, H.: Addiction liabilities of some drugs in the morphine series. Federation Proceedings, 1950, 9(1): 273.

FRASER, H. F.; ISBELL; Harris: Addiction Liabilities of Morphinan, 6-Methyldihydromorphine and Dihydroco-deinone. Journal of Pharmacology and Experimental Therapeutics, 1950, 100 (2): 128-135.

FREIBERG, H.: Ueber den Wert von Entziehungserscheinungen für die Diagnose der Rauschmittelsuchten in der heutigen Zeit (Value of deprivation symptoms in the diagnosis of narcotic addiction). Psychiatrie, Neurologie und medizinische Psychologie, 1950, 2:5, 144-151.

G

GAYRAL; COMBES: Toxicomanie par phenyl-1-amino-2-propane (ortedrine et maxiton). Toulouse médical, 1950, 51, 4, 218-220.

GUILLY, P.: Le club des Hachischins. Encéphale, 1950, 39:2, 175-185.

H

HECHT, S. S.; FRIEDMAN, J.: The high incidence of cervical dental caries among drug addicts. Oral Surgery, 1949, 2, 1428-42.

HEUYER, G.; LEBOVICI, S.: Une nouvelle toxicomanie: le maxiton; à propos de deux observations. Annales médico-psychologiques, 1950, 108:2:3, 353-4.

HOSSICK, K. C.: Some social and economic aspects of drug addiction. Canadian Medical Association Journal, 1950, 63:4, 427-30.

HUSSEY, H. H.; KATZ, S.: Infections resulting from narcotic addiction; report of 102 cases. American Journal of Medicine, 1950, 9:2, 186-193.

I

ISBELL, Harris: The addiction liability of some derivatives of meperidine. Journal of Pharmacology and Experimental Therapeutics, 1949, 97(2): 182-189.

ISBELL, H.: Manifestations and treatment of addiction to narcotic drugs and barbiturates. Medical Clinics of North America, 1950, 34, 425-38.

ISBELL, H.; FRASER, H. F.: Addiction to analgesics and barbiturates. Journal of Pharmacology and Experimental Ther-apeutics, 1950, 99:4:2, 355-97.

L

LARRAMENDI, M. H.; OBRADOR, S.: About the action of certain narcotic drugs on the abnormal waves of the human electroencephalogram. Bulletin of the Institute for Medical Research, 1950, 3:2, 119-24.

LAW, F. E.; RUBLE, J. W.: Dental caries in morphine addicts, as determined by clinical and radiographic examination. Public Health Reports, 1950, 65:41, 1336-40.

LEMKE, R.: Beobachtungen an Süchtigen (Observations on addiction). Nervenarzt, 1950, 21:8, 366-72.

M

MAIER, S.: Ueber Polamidonmissbrauch (Misuse of Polamidon). Medizinische Monatsschrift, 1950, 4:8, 620-1.

MARINI, M.: Considerazioni sul metodo Ottonello nella cura del morfinismo e dialtre tossicomanie (Considerations on the Ottonello method for the cure of morphinism and other drug addictions). Rassegna medica, 1949, 26, 77-80.

MEYLER, L.: Versterkte gevoeligheid voor opiaten en barbituurzuren bij anoxie (Increased sensitivity to opiates and barbituric acid in anoxia). Nederlandsch Tijdschrift voor Geneeskunde, 1950, 94:34, 2467-70.

N

NYSWANDER, M.: Withdrawal treatment of drug addiction. New England Journal of Medicine, 1950, 242, 128-30.

P

PARREIRAS, Decio: Canabismo o Maconhismo (Estudos Brasileiros). (Addiction to Cannabis or maconha) (Brazilian studies). Impresa Medica, 1949, 430, 34-64.

PULLAR-STRECHER, H.: A review on the literature of addiction. British Journal of Addiction, 1949, 46, 105-54.

R

RAZEMON; DOREMIEUX: Corps étrangers abdominaux chez une toxicomane. Lille chirurgical, 1950, 5:27, 131.

RUBIN, A.; WINSTON, J.: The role of the vestibular apparatus in the production of nausea and vomiting following the administration of morphine to man; clinical and experimental data including the effects of dramamine and benzedrine. Journal of Clinical Investigation, 1950, 29:10, 1261-6.

S

SALTER, W. T.: Opium-eating in old Nantucket. Connecticut State Medical Journal, 1950, 14:5, 434-5.

SATTES, H.: Ueber Polamidonsucht (Polamidon addiction) Deutsche Medizinische Wochenschrift, 1950, 75:19, 638-641.

STEIGMANN, F.; HYMAN, S.; GOLD-BLOOM, R.: Infectious hepatitis (Homologous serum type) in drug addicts. Gastroenterology, 1950, 15:4, 642-6.

STEINHAUS, J. E.; TATUM, A. L.: An experimental study of cocaine intoxication and its treatment. Journal of Pharmacology and Experimental Therapeutics, 1950, 100, 351-61.

T

TEWES, H.; RUPPRECHT, H.: Polamidon-Missbrauch (Misuse of polamidon). Münchener Medizinische Wochenschrift, 1950, 92:19-20, 786-7.

U

UNION OF SOUTH AFRICA: Under the influence of narcotic drugs; in the Supreme Court of South Africa. South African Medical Journal, 1950, 24:23, 438-442.

V

VRIES, E. De: Ervaringen over opiummisbruik en ontwenning (Opium addiction and its treatment). Medisch Haanblad, 1949, 2, 328-40.

W

WEDEL, A. P. N.: Opiophagi og morphinisme (Opiophagy and morphinism). Ugeskrift for Laeger, 1950, 112:27, 961-63.

WOLFF, P.O.: Problems of drug addiction in South America. British Journal of Addiction, 1949, 46, 66, 78.

Z

ZALMAN, E.: Leceni narkomanii podminenou reakci zvracivou (Treatment of drug addiction by conditioned vomitive reaction). Lekarske Listy, 1950, 5:11, 323-328.