Synthetic Drugs - I and II

Sections

INTRODUCTION
I. General
II PETHIDINE

Details

Pages: 73 to 83
Creation Date: 1954/01/01

BIBLIOGRAPHY

Synthetic Drugs - I and II

INTRODUCTION

The following bibliography has been prepared by the Secretariat and includes the first two parts of a general bibliography on synthetic drugs. The other parts will deal with methadone-III, morphinan and morphine synthesis-IV, dithienylbutenylamines and miscellaneous synthetics-V. The three last parts will be given in Volume VI, No. 3-4.

The Bulletin has already published a Bibliography on Synthetic Drugs (Volume III, No. 2) but since 1950 a great quantity of new works have been published justifying this second bibliography on the same subject. Thisbibliography has no claim to be complete and information regarding books or articles not included in it would be gratefully received by the Division of Narcotic Drugs, United Nations Secretariat. Due to the nature of the sources available to the Secretariat, several titles are given in translation only. They are preceded by an asterisk.

I. General

A

AMELINK, F.: Identificatie van enkele nieuwe geneesmiddelen langs microchemische weg (Microchemical identification of certain new drugs). Pharmaceutisch Weekblad, 1952, 87:47.48,p. 821-835

ANONYMOUS: Narcotics regulation. The Yale Law Journal 1953, 62:5, p. 751-787

--: Narcotic supplies. Journal of the American Medical Association, 1953, 152:17,p. 1634

ANSLINGER, H. J.: Regulatory problems of the new analgesics under the narcotic law. Annals New York Academy of Sciences, 1948, 51:1,p. 134-136

ANSTEE, J. R.: Chemical structure and analgesic activity. Australasian Journal of Pharmacy, 15 August 1951, 32: Brisbane Jubilee Conference Issue, p. 820-826

B

BATTERMAN, R. C.: The importance of addiction to the newer synthetic analgesics in human therapy. Annals New York Academy of Sciences, 1948, 51:1,p. 123-129

BECKETT, A. H.; CASEY, A. F.: Stereochemistry of certain analgesics, Nature,1954, 173:4417,p. 1231-1232

BEECHER, H. K.: Study of analgesics. Bulletin on Narcotics, 1951, 3:4, p. 9-15

BRAENDEN, O. J.; WOLFF, P. O.: Synthetic substances with morphine-like effect. Bulletin of the World Health Organization, 1954, 7:10, p. 1-25

BRANDSTAETTER, M.: Zum mikroskopischen Nachweis morphin?hnlich wirkender Verbindungen (Microscopic identification of substances with morphine-like action). Arzneimittel-Forschung,1953, 3:1, p. 33-34

BREINLICH, J.: Zum mikrochemischen Nachweis einiger Analgetica, insbesondere von Polamidon und Ticarda (H?chst), Cliradon (Ciba) und Dromoran (Roche) (Microchemical determination of certain analgesics, particularly polamidon, ticarda, cliradon and dromoran). Pharmazie,1952, 7:10, p. 694-695; also in Arzneimittel-Forschung,1953, 3:2, p. 93-96

BRITISH MEDICAL ASSOCIATION: The relief of pain. The Lancet, 1952, 263:6725 ,p. 129-130

BROWN; D. J.; COOK, A. H.; HEILBRON, I.: Preparation of potential analgesic compounds. Part I, Journal of the Chemical Society (London), 1949 (supplemental issue No. 1), p. S 106-111; Part II, ibid.,p. S 111-112; Part III, ibid.,p. S 113-115

BROWN, J. M.; VOLPITTO, P. P.: Clinical impressions of some of the newer analgesic agents. Journal of the Medical Association of Georgia, 1950, 39:2 ,p. 63-66

BROWN, R. C.: A study of the maternal blood pressure variations in 50 cases of normal labour, with a consideration of the effects of analgesia. Anaesthesia.1951. 6:2. p. 66-75

BRUNZELL, A.: NFN-Navne (NFN names). Svensk Farmaceutisk Tidskrift, 1951, 55:3 ,p. 37-44

C

CARRATALA ,R.; COSTA, A. J.; COSENTINO, R.: Derivados de la metadona y de la petidina, inconvenientes de su venta libre, el heptan (Methadon and pethidine derivatives, hazards in public sale, heptane). Revista de la Asociaci?n M?dica Argentina, 1953, 67:747-748, p. 102-104

CHAPIN, M.: The newer drugs. Journal of the Maine Medical Association, 1949, 40:2,p. 40-42

CHEN, J. Y. P.; BECKMAN, H.: A satisfactory apparatus for study of analgesia in mice. Science,1951, 113:2944 , p .631

COSTELLO, C.; MCDONALD, J.: The role of a new analgesic in surgery. Journal of the Missouri State Medical Association, 1949, 46:5,p .333-337

CULLEN, S. C.: Use of depressant drugs. Journal of the American Association of Nurse Anesthetists, 1952, 20:3 ,p .167-174

D

DENEAU, G. A.; GOWDEY, C. W.: Method of measuring mild analgesia in man. Federation Proceedings, 1952, 11:1 . I. p. 338

DENTON, J. E.; BEECHER, H. K.: New analgesics. I. Methods in the clinical evaluation of new analgesics. ]ournal of the American Medical Association, 1949, 141:15, p. 1051-1057

DODDS, E. C.: The search for morphine substitutes. British Medical Bulletin, 1946, 4:2, p. 88-91

DUFRESNE, R. R.: Les medicaments nouveaux. Canadian Nurse, 1949, 45:2, p. 127-129

E

EDDY, N. B.: The relation of chemical structure to analgesic action. Journal of the American Pharmaceutical Association, sc. ed., 1950, 39:5, p. 245-251

F

FARMILO, C. G.; LEVI, L.; OESTREICHER, P. M. L.; ROSS, R. J.: Studies on the identification of narcotics. III. Microcrystal and colour tests for the new synthetic narcotics. Bulletin on Narcotics, 1952, 4:4, p. 16-42

FERRER, M. I.; SOKOLOFF, L.: Antidiuretic effect of morphine and demerol in congestive heart failure. American Journal of Medical Science, 1947, 214:4, p. 372-384

FLEISCH, A.; DOLIVO, M.: Auswertung der Analgetica im Tierversuch (Testing analgesics on animals). Helvetica physiologica pharmacologica Acta, 1953, 11:3, p. 305-322

FOSTER, R. H. K.; DEBOER, B.: Respiration apparatus for rabbits and its use in the study of piperidine analgesics. Federation Proceedings, 1949, 8:1, I, p. 292

FRASER, H. F.; ISBELL, H.; VANHORN, G. D.; NASH, T. L.: Use of measurements of miotic effects in evaluating analgesic drugs in man. Journal of Pharmacology and Experimental Therapeutics, 1954, 110:1, p. 19

FUJIMURA, Hajime: Relation between analgesic effect of drugs and the chemical structures. Bulletin of the Institute for Chemical Research, Kyoto University, 1952, 30:9, p. 53-54

G

GLASSON, B.: Quelques aspects r?cents du domaine des succ?dan?s synth?tiques de la morphine. Revue m?dicale de la Suisse romande, 1953, 73:3, p. 159-165

--: Etat actuel de la question des succ?dan?s synth?tiques de la morphine, ibid., 1951, 71:7, p. 484-492

GOVIDA RAO, A. R.: The use of new synthetic analgesics in surgery. Antiseptic, 1950, 47:9, p. 689-691

GREWAL, R. S.: A method for testing analgesics in mice. British Journal of Pharmacology and Chemotherapy, 1952, 7:3, p. 433-437

GROSS, E. G.; BROTMAN, M. A.; NAGYFY, S. F.; SAWTELLE, W. W.; ZAGER, L. I.: New potent analgesic agent. Federation Proceedings, 1949, 8:1, I, p. 297

GRUBER, C. M.; KWANG SOO LEE; GRUBER, C. M.: A comparison of the actions of meperidine, Nu-l196, methadone, morphine, Nu-2206, and metopon upon the intestine and uterus. Journal of Pharmacology and Experimental Therapeutics, 1950, 99:3, p. 317-324

H

HAAS, H.: Vergleichende Untersuchungen mit Analgetika (Comparative studies of analgesics). Archiv f?r experimentelle Pathologie und Pharmakologie, 1950, 212:1-2, p. 162-163

HAAS, H.; HOHAGEN, E.; KOLLMANNSPERGER, G:. Vergleichende Untersuchungen mit Analgeticis (Comparative studies with analgetics). Arzneimittel-Forschung, 1953, 3:5, p. 238-247.

HAMMES, E. M. Jr.: Pain-relieving drugs. Journal-Lancet, 1952, 72:2, p. 67-71

HEBB, C. O.; KONZETT, H.: Difference between morphine and synthetic analgesics in their action on ganglionic transmission. Nature (London) 1949, 163:4149, p. 720-721

- - ; - - : The effect of certain analgesic drugs on synaptic transmission as observed in the perfused superior cervical ganglion of the cat. Quarterly Journal of Experimental Physiology, 1949, 35:3, p. 213-217

HELLIWELL, P. J.; HUTTON, A. M.: Analgesia in obstetrics. Anaesthesia, 1949, 4:1 p.18-21

HERSHENSON, B. B.: Use of new synthetic analgesics in obstetrics, Annals N. Y. Academy of Sciences, 1948, 51:1, p. 151-160

HEWER, A. J. H.; KEELE, C. A.: Analgesics, a method of testing in man. Lancet, 1948, 255:6531, p. 683-688

- - ; - - ; et al.: A clinical method of assessing analgesics. ibid. 1949, 256:6550, p. 430-435

HEWER, L.: Recent advances in anaesthesia and analgesia (6th ed.) 1948, 215 pp. J. & A. Churchill, London

HOLLAND, H. L.; GROSS, E. G.: Two new analgesics. Federation. Proceedings, 1948, 7:1, I, p. 227-228

HOUDE, R. W.; RASMUSSEN, L. H.; LA DUE, J. S.: Preliminary experiences in the use of some of the newer analgesics in the relief of pain due to cancer. Annals New York Academy of Sciences, 1948, 51:1, p. 161-174

HOUDE, R. W.; WIKLER, A.; IRWIN, S.: Comparative actions of analgesic, hypnotic and paralytic agents on hindlimbs reflexes in chronic spinal dogs. Journal of Pharmacology and Experimental Therapeutics, 1951, 103:3, p. 243-248

HOUDE, R. W.; WALLENSTEIN, S. L.: Method of screening analgetics in cancer patients. Federation Proceedings, 1953, 12:1, I, p. 332 (No. 1095)

I

IRWIN, S.; HOUDE, R. W.; BENNETT, D. R.; HENDERSHOT, L. C.; SEEVERS, M. H.: The effects of morphine, methadone and meperidine on some reflex responses of spinal animals to nociceptive stimulation. Journal of Pharmacology and Experimental Therapeutics, 1951, 101:2, p. 132-143

IRWIN, S.; SEEVERS, M. H.: Neurological changes in the monkey following acute and chronic administration of morphine-like analgesics. Journal of Pharmacology and Experimental Therapeutics, 1954, 110:1, p. 27-28

ISBELL, H.: Methods and results of studying experimental human addiction to the newer synthetic analgesics. Annals New York Academy of Sciences, 1948, 51:1, p. 108-122

J

JACKSON, H.: Evaluation of analgesic potency of drugs using thermal stimulation in the rat. British Journal of Pharmacology and Chemotherapy, 1952, 7:2, p. 196-203; Effect of analgesic drugs on the sensation of thermal pain in man, ibid., p. 204-214

K

KAUFMANN, H. P.: Arznelmittel-Synthese (Synthetic drugs). 1953, Berlin, Springer Verlag, 834 pp.

KEELE, C. A.: Assay of analgesic drugs on man. Analyst, 1952, 77:912, p. 111-117

- - : Analgesic drugs. Practitioner, 1953, 170:1019, p. 515-521

KEWITZ, H.; REMMER, H.; ENGELHARDT, H.: Die Wirkung von Morphin, Dolantin und Polamidon auf den D?nndarm des Menschen (Effect of morphine, dolantin and polamidon on the small intestine of man). Klinische Wochenschrift, 1951, 29:33-34, p. 570-571

KIMURA, K. K.; KEITH, E. F.; FOSTER, R. H. K.: Further studies on hyperglycemia produced by morphine-like analgesic agents. Federation Proceedings, 1952, 11:1, I, p. 363

KIRCHHOF, A. C.: Further studies on synthetic analgesics. Federation Proceedings, 1948, 7:1, I, p. 234 .

KNOLL, J.; KOMLOS, E.; TARDOS, L.: Ueber die Rolle der Eiweissbindung im Synergismus der Analgetika und Parasympathomimetika. (Role of the protein complex in the synergism of analgetics and parasympathomimetics). Acta physiologica academiae scientiarum Hungaricae, 1953, 4:1-2, p. 131-140

KOENIG, R.; MAGYAR, K.: (New analgesic compounds with morphine-like effects). Magyar kemiai foly?irat, 1950, 56, p. 77-81

KROOK, G.: Narkotika och 1948 ?rs Parisprotokoll (Narcotics and 1948 Paris protocol). Svensk farmaceutisk tidskrift, 1953, 57:32, p. 625-627

KUELZ, F.: KOLL, W.: Chemische Konstitution und zentralanalgetische Wirkung (Chemical constitution and central analgetic action). Archiv f?r experimentelle Pathologie und Pharmakologie, 1952, 216:1-2, p. 141-142

L

LALANNE, P.: Les stup?fiants synth?tiques. Cahiers La?nnec, 1953, 13:2, p. 11-29

LAPIERE, C.: Les analg?siques de synth?se. Revue m?dicale de Liege, 1953, 8:3, p. 85-95

LEHMAN, R. A.; KUPPERMAN, H. S.; PHILLIPS, J.: Studies on the relationship between chemical constitution and analgesic activity. Federation Proceedings, 1948, 7:1, I, p. 237-238

LENDLE, L.: Spezifische Behandlung von Vergiftungen mit Morphin und synthetischen Opiaten durch Nalorphine (Specific therapy with nalorphine in poisoning with morphine and other synthetic opiates). Deutsche medizinische Wochenschrift, 1953, 78:35, p. 1140-1141

LESPAGNOL, A.: Analg?siques centraux de synth?se. Actualit?s pharmacologiques, 1951, 3, p. 27-47

- - : Succ?dan?s de la morphine. Nouveaut?s m?dicales, 1953, 1, p. 5-12

- - ; BAR, D.: Les proc?d?s g?n?raux de la recherche en chimie m?dicamenteuse. L'Echo m?dical du Nord, 1953, 24:5, p. 134-156

LEVI, L.; FARMILO, C. G.: Characterization of narcotics as Reineckates. Canadian Journal of Chemistry, 1952, 30:10, p. 783-792. Quantitative determination of narcotics by ion exchange, ibid. p. 793-799

LEVI, L.; OESTREICHER, P. M.; FARMILO, C. G.: Nonaqueous titration of narcotics and alkaloids. Bulletin on Narcotics, 1953, 5:1, p. 15-25

LEWIS, J. R.: Development of tolerance in rats to some new synthetic analgesics . Journal of Pharmacology and Experimental Therapeutics, 1949, 96:1, p. 31-37; also in Federation Proceedings, 1949, 8:1, p. 315-316

LINZ, A.: Die neueren Bet?iubungsmittel. (New narcotics). Pharmazeutische Zeitung-Nachrichten, 1952, 88:17, p. 419-423

LONGO, V. G.; NAPOLITANO, L.: Farmacologia del riflesso vestibulo-oculare. Nota I. Azione degli analgesici, barbiturici, convulsivanti e farmaci del sistema nervoso vegetativo sul nistagmo postrotatorio del coniglio (Pharmacology of the vestibuloocuar reflex. I. Action of analgesics, barbiturates, convulsive drugs and drugs of the vegetative nervous system on post rotatory nystagmus in the rabbit). Archives internationales de pharmacodynamie, 1952, 92:2, p. 177-191

- - ;· - - : Action of analgesic drugs (morphine, meperidine, methadone) on rotary nystagmus in the rabbit. Journal of Pharmacology and Experimental Therapeutics, 1953, 107:2, p. 154-159

LUDUENA, F. P.: ANANENKO, E.: The pharmacodynamic effects of some new analgesics. Archives internationales de pharmacodynamie et de th?rapeutique, 1950, 81:3, p. 259-2757

M

MARTELLI?RE, E.: Le r?gime des stup?fiants et des radio?l?ments. Produits pharmaceutiques, 1953, 8:6, p. 327-333

MAY, E. L.: The chemistry of drugs of addiction. American Journal of Medicine, 1953, 14:5, p. 540-545

MERCIER, F.; MERCIER, J.; SESTIER, M. R.: Influence exerc ?e par quelques analg?siques centraux synth?tiques sur la motricit? de la r?gion pylorique chez le chien chloralos?. Comptes rendus, Soci?t? de Biologie, 1950, 144:21, p. 1536-1538

MILLER, L. C.: A critique of analgesic testing methods. Annals of the New York Academy of Sciences, 1948, 51:1, p. 34-50

N

NATHAN, P. W.: Newer synthetic analgesic drugs. British Medical Journal, 1952, 2:4790, p. 903-908

NELSON, E. E.: The Federal Food, Drug and Cosmetic Act and new analgesic drugs. Annals New York Academy of Sciences, 1948, 51:1, p. 130-133

P

PAPPER, E. M.: An appraisal of some analgesic agents and methods. Pennsylvania Medical Journal, 1950, 53:8, p. 801-806

PETER, Sister M.: Modern methods of minimizing pain during labor and childbirth. Journal of the American Association of Nurse Anesthetists, 1948, 16:4, p. 302-305

PETERSEN, P. V.: Studies on a new spasmolytic compound 1,1-diphenyl-3-dimethylaminobutene-1 (A29), related to methadone, and on the combined use of this compound and a potent analgesic, Ketobemidone. (A21) Acta Pharmacologica et toxicologica, 1951, 7:1, p. 51-64

PFEIFFER, C. C.: Synthetic drugs as specific analgesics. Modern Hospital, 1951, 76:3, p. 100-106; - , et al: Experimental methods for the study of analgesia. Annals of the New York Academy of Sciences, 1948, 51:1, p. 21-33

PRESCOTT, F.; RANSOM, S. G.; THORP, R. H.; WILSON, A.: Effect of analgesics on respiratory response to carbon dioxide in man. Lancet, 1949, 256:6548, p. 340-344

R

ROBSON, J. M.; NISSIM, J. A.: The new analgesics. Chemical Products (London), 1949, 12. p. 284-292, 297

RODRIGUEZ, M. L.; BALESTIE, I.: Contribuci?n al estudio qu?mico funcional de analg?sicos sint?ticos de acci?n similar a la morfina (Functional study of synthetic analgesics exerting a morphine-like action). Anales de la asociaci?n de qu?mica y farmacia del Uruguay, 1951, 51:2, p. 43-48

ROVENSTINE, E. A.: Use of new synthetic analgesics in surgery. Annals of the New York Academy of Sciences, 1948, 51:1, p. 145-150

S

SALVESEN, B.; PAULSEN, A.: Papirkromatografisk arskillelse og identifisering av noen analgetika beslektet med morfin (The separation and identification of some analgesic compounds related to morphine by paper chromatography). Meddelelser fra Norsk farmaceutisk selskap, 1953, 15:4, p. 33-42

SANTARATO, R.: Azione dei farmaci sul metabolismo del piruvato nei feti e negli animali giovani. II. Morfina e morfinosimili di sintesi (Effect of drugs on the metabolism of pyruvate in fetuses and young animals. II. Morphine and synthetic morphine-like drugs). Bollettino della societ? italiana di biologia sperimentale, 1953, 29:4, p. 628-630

SCHAUMANN, O.: Die neuen synthetischen Analgetica (New synthetic analgesics) Scientia pharmaceutica, 1951, 19:1, p. 33-41; also in Archiv f?r experimentelle Pathologie und Pharmakoelogie, 1952, 216:1/2, p. 48-77 ; Oesterreichische chemische Zeitung, 1952, 53:19-20, p. 225-233

SCHAUMANN, O.; JOCHUM, K.; SCHAUMANN, W.: Analgetika und Darmmotorik. II Wirkung auf den L?ngsmuskeltonus (Analgetics and intestinal peristalsis. (II. Effects on the longitudinal muscle tonus). Naunyn-Schmiedeberg's Archiv f?r exprimentelle Pathologie und Pharmakologie , 1953, 217:4, p. 360-365

- - - ; - - - ; SCHMIDT, H.: Do. III.. Zum Mechanismus der Peristaltik (III. Mechanism of peristalsis), ibid. 1953, 219:4, p. 302-309

SCOTT, C. C.; KOHLSTAEDT, K. G.; CHEN, K. K.: Comparison of the pharmacologic properties of some new analgesic substances. Current researches in anesthesia and analgesia, 1947, 26:1, p. 12-17

SEEVERS, M. H.: Animal experimentation in studying addiction to the newer synthetic analgesics. Annals New York Academy of Sciences, 1948, 51:1, p. 98-107; Pharmacology of the newer synthetic analgesics. Oral Surgery, 1949, 7:1, p. 30-38

SLAUGHTER, D.; NEFF, J.; MAY, M.: Human studies on synthetic analgesics. Transactions of the American Therapeutic Society, 1947, 48, p. 155-159

SLOMKA, M. B.; SCHUELER, F. W.: Chemical constitution and analgetic action. Federation Proceedings, 1950, 9:1, p. 316; also in Journal of the American Pharmaceutical Association, 1951, 40:1, p. 47-51; University microfilms (Ann Arbor, Mich.), Pub. No. 4052, 59 pp.

SMALL, L. F.: Chemistry of natural and synthetic analgesics. Annals New York Academy of Sciences, 1948, 51:1, p. 12-20

SMITH, A.: Safeguards in the use of new drugs. Bulletin New York Academy of Medicine, 1949, 25:2, p. 115-124

SMITH, C. C.; LEHMAN, E. G.: Analgesics. I. Effects of analgesic combinations on reaction time in rats. Journal of Pharmacology and Experimental Therapeutics, 1953, 108:3, p. 336-339

SMITH, E. J.; NAGYFY, S. F.: A report on comparative studies of newer drugs used for obstetrical analgesia. American Journal of Obstetrics and Gynecology, 1949, 58:4, p. 695-702

T

TAINTER, M. L.: Newer synthetic analgesics, New York Academy of Sciences, New York, 1948. Also in: Annals of the New York Academy of Sciences, 1948, 51:1, p. 1-174

TENNYSON, A. L.: History and mechanism of international and national control of drugs of addiction. American Journal of Medicine, 1953, 14:5, p. 578-585

TYE, A.; CHRISTENSEN, B. V.: The estimation of some analgetic potencies. Journal of the American Pharmaceutical Association, 1952, 41:2, p. 75-77

U

UNITED NATIONS SECRETARIAT: New narcotic drugs and their international control. Bulletin on Narcotics, 1952, 4:1, p. 1-5

V

VAILLE, C.; STERN, G.: Le probl?me des stup?fiants synth?tiques. Presse m?dicale, 1951, 59:33, p. 670-672

VAN ARSDEL III, W.; DAVID, N. A.: (T) Constipative effects of Hydergine (CCK-179) and analgesic compounds on the rabbit. Journal of Pharmacology and Experimental Therapeutics, 1954, 110:1, p. 50

VAN DYKE, H. B.: Synthetic analgesic drugs, American Journal of Medicine, 1949, 6:6, p. 681-683

--: New analgesic drugs. Bulletin New York Academy of Medicine, 1949, 25:3, p. 152-175

VOGT, H.; HEEMANN, I.: (Determination of modern analgetics with Reinecke salt) Pharmazeutische Zentralhalle, 1952, 91, p. 311-315

>VOTAVA, Z.; HOR?KOV?, Z.: (Comparison of the analgesic effect of morphine, methadone and demerol). Cechoslovenska farmacie, 1952, 1, p. 338-347

--; CERNA, H.; PODVALOVA, I.: Farmakologicky vyzkum synthetickych uterotonik (Pharmacological studies on synthetic uterine tonic drugs). Casopis l?kar? Ceskych, 1953, 92:35, p. 939-944

W

WALLENSTEIN, S. L.; HOUDE, R. W.: Changes in pain intensity as a means of estimating analgetic power. Federation Proceedings, 1953, 12:1, p. 377-78 (No. 1243)

WALSH, F. J.: Analgesia and anesthesia in obstetrics. Boletin de la asociaci?n m?dica de Puerto Rico, 1950, 42:5, p. 294-299

WANG, R. I. H.; BAIN, J. A.: Analgesics and enzymes of the cytochrome chain. Journal of Pharmacology and Experimental Therapeutics, 1953. 108:3, p. 354-361

WATTS, D. T.: Inhibition of succinic oxidase system by meperidine, methadon, morphine, and codeine. Journal of Pharmacology and Experimental Therapeutics, 1949, 95:2, p. 117-121

WAYNE, E. J.: The newer analgesics, Practitioner, 1948, 161:961, p. 52-58; Los analg?sicos m?s modernos (The newer analgesics). Jornada m?dica (Buenos Aires), 1949, 3: No. 23, p. 221-226

WEBB, J. L.; ELLIOTT, K. A. C.: Effects of narcotics and convulsants on tissue glycolysis and respiration. Journal of Pharmacology and Experimental Therapeutics, 1951, 103:1, p. 24-34

WEIGMANN, R.; WOEHLER, C.: (The testing of analgetic substances with the aid of the prickle apparatus of Frey). Arzneimittel-Forschung, 1952, 2, p. 218-221

WESTERLING, R.: (Narcotics - a survey). Svensk farmaceutisk tidskrift, 1952, 56, p. 509-517

WIKLER, A.: Sites and mechanisms of action of morphine and related drugs in the central nervous system. Journal of Pharmacology and Experimental Therapeutics, 1950, Part II, 2:3, p. 435-506

WILBRANDT, W.: Die neuen Zentralanalgetika (The new central analgetics). Praxis, 1952, 41:40, p. 866-870

WILKINS, D. S.; CULLEN, S. C.; BROTMAN, M.: Intravenous supplementation during nitrous oxide anesthesia: Application of multiple covariant analysis to the comparison of demerol, morphine and a new potent analgesic drug (15431). Anesthesiology, 1951, 12:2, p. 145-163

WILLIAMS, E. M. V.; STREETEN, D. H. P.: The action of morphine, pethidine, and amidon upon the intestinal motility of conscious dogs. British Journal of Pharmacology and Chemotherapy, 1950, 5:4, p. 461-464

WILSON, W.; KYI, Z. Y.: Synthetic analgesics and related compounds. IV. Mannich bases from phenyl-substituted acetones. Journal of the Chemical Society, 1952, 240, 1321-1326

II PETHIDINE

A

ABEL, S.; BALL, Z. B.; HARRIS, S. C.: The advantages to mother and infant of amphetamine in obstetrical analgesia. American Journal of Obstetrics and Gynecology, 1951, 62:1, p. 15-27

ABRAMSON, A. S.: Local anesthesia improved by co-medication with meperidine hydrochloride. Dental items of interest, 1952, 74:9, p. 799-805

AKAD, S.: The effects on the cat of addictive morphine derivatives and synthetic drugs. Bulletin on Narcotics, 1952, 4:1, p. 10-14

ALTSCHUL, S.; WIKLER, A.: Electrocephalogram during a cycle of addiction to ketobemidone hydrochloride. EEG and Clinical Neurophysiology, 1951, 3:2, p. 149-153

ANDERSEN, H. C.; JEPSEN, O.; KRISTIANSEN, F.: Nystagmus induced by pethidine. Acta Oto-Laryngologica, Supplementum, 1953, No. 109, p. 9-14

ANDREWS, H. L.: Development of tolerance to demerol. Journal of Pharmacology and Experimental Therapeutics, 1942, 75:3, p. 338-341. Cortical effects of demerol. Journal of Pharmacology and Experimental Therapeutics, 1942, 76:1, p. 89-94

ANONYMOUS: Pethidine and the liver. Medical World, 1952, 77:12, p. 340-341

ANSLINGER, H. J.: Addiction to demerol and the Readers Digest. Journal of the American Medical Association, 1946, 131:11, p. 937

APGAR, V.; BURNS, J. J.; BRODIE, B. B.; PAPPER, E. M.: The transmission of meperidine across the human placenta. American Journal of Obstetrics and Gynecology, 1952, 64:6, p. 1368-1370

ARMAND, M. F.: Analg?sie par le d?m?rol ? la Maternit? de Chancerelles. Gazette m?dicale de France, 1952, 59:19, p. 1115-1118

AULD, W.: Pethidine, curare, nitrous oxide-oxygen anaesthesia in children. Anaesthesia, 1952, 7:2, p. 161-165

*AUVINEN, E. E.: Dolanton-evipan-natrium-narkoosista (Dolanton-evipan sodium narcosis). Sotilas l??ketietallinen Aikakauslehti, 1952, 27:3, p. 57-61

AVISON, A. W. D.; MORRISON, A. L.: Synthetic analgesics. Part VI. The synthesis of ketobemidone. Journal of the Chemical Society, 1950, p. 1469-1471; Part VII. Metadine and related 3-phenylpiperidine derivatives. ibid. p. 1471-1474; Part VIII. Further attempts to prepare 3-phenylpiperidine derivatives. ibid. p. 1474-1478

B

BARCLAY, S.: Pethidine as an adjunct in local anaesthesia; a clinical note. New Zealand Medical Journal, 1952, 51:282, p. 115-117

BARLOW, O.; LEWIS, J. R.: Toxicology and addiction liability of meperidine (demerol) in experimental animals. Journal of Pharmacology and Experimental Therapeutics, 151, 103:2, p. 147-152

BARNES, J.: Pethidine in labour: results in 500 cases. British Medical Journal, 1947, 1:4500, p. 437-442; Pethidine hydrochloride in labour. Practitioner, 1950, 164:979, p. 91

BATTERMAN, R. C.: The treatment of arthritic pain with demerol, a new synthetic analgesic. Annals of Internal Medicine, 1945, 22:3, p. 382-385

BATTERMAN, R. C.; HIMMELSBACH, C. K.: Demerol, a new synthetic analgesic. Journal of the American Medical Association, 1943, 122:4, p. 222-226

BEATON, D.: Pethidine in labour. Edinburgh Medical Journal, 1948, 55:6, p. 354-361

BERGEL, F.; HAWORTH, J. W.; MORRISON, A. L.; RINDERKNECHT, H.: Synthetic analgesics. Part I. Synthesis of basic Benzo-furan derivatives and certain 4-phenylpiperidine compounds. Journal of the Chemical Society, 1944, p. 261-265

--; MORRISON, A. L.; RINDERKNECHT, H.: Do. Part II. A new synthesis of Pethidine and similar compounds, ibid., 1944, p. 265-267; Part III. The action of hydrogen halides on ethers of &alpha&alpha-bis-( &beta-hydroxyethyl)phenyl-acetonitrile. ibid., 1944, p. 267-269

BERGEL, F.; HINDLEY, N. C.; MORRISON, A. L.; RINDERKNECHT, H.: U. S. patent 2,403,903, 16 July 1946. Manufacture of piperidine derivatives

--; HINDLEY, N. C.; MORRISON, A. L.; RINDERKNECHT, H.: Do. Part IV. Synthesis of 3-substituted piperidines and pyrrolidines, ibid., 1944, p. 269-272

BERGER, L.; ZIERING, A.; LEE, J.: Piperidine derivatives. IV. 4-alkyl-, 4-cycloalkyl-, and 4-heterocyclyl-piperidines, Journal of Organic Chemistry, 1947, 12:6, p. 904-910

BERMUDES, C.: Contribution ? l'emploi des spasmolytiques, no-tamment de la dolantine. Gyn?cologie et obst?trique, 1948, 47:6, p. 849-850

BERNHEIM, F.: BERNHEIM, M. L. C.: The hydrolysis of demerol by liver in vitro. Journal of Pharmacology and Experimental Therapeutics, 1945, 85:1, p. 74-77

BERNSMEIER, A.: HEINE, G.: Klinische Erfahrungen und experimentelle Untersuchungen mit dem neuen synthetischen Analgeticum Cliradon. (Clinical experiments and experimental research with the new synthetic analgesic Cliradon. Neue medizinische Welt, 1950, 1:45, p. 1491-1493

BERNSTEIN, A.: Klinische Erfahrungen mit Cliradon, einem neuen synthetischen Analgeticum (Clinical experiments with Cliradon, a new synthetic analgesic). Schweizerische medizinische Wochenschrift, 1949, 79:48, p. 1159-1162

BLANKE, K.: Ergebnisse der klinischen Erprobung des neuen Analgeticums Cliradon (Results of clinical examination of Cliradon, a new analgetic). Medizinische Klinik, 1950, 45:37, p. 1171-1174

BLAZEBY, R. H.: The position of pethidine in anaesthesia. Anaesthesia, 1951, 6:3, p. 168-171

*BOISSON, P.: (Pethidine in general anaesthesia). Acta Anaesthesiologica Belgica, 1952, 3:1, p. 7-14

BOURNE, H. B.; ROSS, R. C.; PHILPOTT, N. W.: Intravenous alcohol in obstetrical labour. Canadian Medical Association Journal, 1953, 69:3, p. 250-253

*BREINLICH, J.: Nachweis von Dromoran und Cliradon neben Morphin im Urin durch Tr?bungsreaktion (Assay of Dromoran and Cliradon in the presence of morphine by a nephelo-metric reaction). Arzneimittel-Forschung, 1953, 3:4, p. 212-213

BROTMAN, M.; CULLEN, S. C.: Supplementation with demerol during nitrous oxide anesthesia. Anesthesiology, 1949, 10:6, p. 696-705

BROTMAN, M.; CULLEN, S. C.; WILKINS, D. S.: Intravenous supplementation during nitrous oxide anesthesia: comparison of demerol, morphine and a new potent analgesic drug (15431). Anesthesiology, 1950, 11:5, p. 527-537

BROUGHER, J. C.: Demerol in obstetrics. Western Journal of Surgery, Obstetrics and Gynecology, 1948, 56:9, p. 480-481

BROWN, J. M.; VOLPITTO, P. P.; TORPIN, R.: Intravenous demerol-scopolamine amnesia during labor. Anesthesiology, 1949, 10:1, p. 15-24

BUSCHKENS, J. P.: Pethidine als hoestwerend middel tijdens intratracheale narcose (Meperidine (Pethidine) for prophylaxis of cough during intratracheal anesthesia). Nederlandsch Tijdschrift voor Geneeskunde, 1953, 97:6, p. 331-335

BUTLER, E. B.: A case of hypersensitivity to pethidine in a woman in labour, British Medical Journal, 1951, 2:4733, p. 715-716

C

CALESNICK, B.; SMITH, N. H.; BEUTNER, R.: Combined action of cardiotoxic drugs; a study on the acute toxicity of combined quinidine, meperidine, pentobarbital, procaine and procaine amide. Journal of Pharmacology and Experimental Therapeutics, 1951, 102:2, p. 138-143

CAPRARO, V.: Ricerche sperimentali comparative sulla attivit? spasmolitica del dolantinici e di nuovi composti ad azione analoga (Comparison of the spasmolytic action of dolantin analoga and of new compounds of analogous action). Farmaco (scienza e tecnica), 1948, 3:2, p. 137-144

CARMICHAEL, E. B.; JOHNSON, W. H.; KAY, F. A.: Toxicity studies with demerol hydrochloride (isonipecaine) on adult male guinea pigs. Federation Proceedings, 1949, 8:1, p. 190

CARRATAL?, R.; COSTA, A. J.; COSENTINO, R.: Derivados de lametadona y de la petidina, inconvenientes de su venta libre. El heptan (Methadon and pethidine derivatives, hazards in public sale. Heptane). Revista de la As?ciaci?n m?dica Argentina, 1953, 67:747-748, p. 102-104

CARRIERE, B.: Klinische Beitr?ge zur Cliradonsucht unter besonderer Ber?cksichtigung der Entziehungspsychosen (Clinical contributions to Cliradon addiction with special reference to withdrawal psychoses). Deutsche medizinische Wochenschrift, 1953, 78:24, p. 875-877

CHRISTENSEN, E. M.; Gross, E. G.: Analgesic effects in human subjects of morphine, meperidine and methadon. Journal of the American Medical Association, 1948, 137:7, p. 594-599; Efecto analg?sico comparativo de la morfina, la meperidina y el metadon (Comparison between the analgesic effects of morphine, meperidine and methadon). Am?rica clinica, 1948, 13:5, p. 414-417

CIBA: British patents, No. 609,763, 21 March 1946; No. 614,567, 12 July 1946. Manufacture of piperidyl ketones

CIBA Aktiengesellschaft (Basel, Switzerland): Swiss patents, No. 259,121, 1 June 1949, Verfahren zur Herstellung eines neuen Piperidylketons (Manufacturing process of a new pipe-ridylketone): No. 259,442, 1 July 1949, Verfahren zur Dar-stellung eines 4-Aryl-piperidin-4-carbons?ure-esters (Preparation of one of the esters of 4-Aryl-piperidine-4 carboxylic acid); also British patent No. 597,794, 27 August 1945; Swiss patent No. 262,428, 1 October 1949, Verfahren zur Herstellung einer Piperidinverbindung (Manufacturing process of a piperidin compound); No. 269,656, 16 October 1950, Verfahren zur Herstellung einer neuen Piperidinverbindung (Manufacturing process of a new piperidin compound)

CIESLAK, G.: Ueber Cliradonsucht (Cliradon addiction). Medizinische Klinik, 1952, 47:21, p. 711-712

CIMOCH, P. J.; WIRTS, C. W.: Meperidine hydrochloride used intravenously before gastroscopy. Journal of the American Medical Association, 1953, 153:11, p. 1004-1006

CLIMENKO, D. R.; BERG, H.: Influence of demerol on contractions of ureter. Journal of Urology, 1943, 49:2, p. 255-258

COHEN, A. E.: Ingestion of 1250 mg of demerol (isonipecaine) with suicidal intent; a case report. Annals of Allergy, 1950, 8:4, p. 547-549

COSTELLO, M. A.; TURNER, C.; HAWKINS, M.; GLENN, M.: Choice of anesthesia for surgical hip pinning in the aged. A report of 250 cases. Journal of the American Association of Nurse Anesthetists, 1952, 20:2, p. 90-94

COWDEN, A. M.: Intravenous demerol and scopolamine in the management of labor, Journal of the Medical Association of Alabama, 1951, 21:3, p. 53-55

CRIMENI, R.: Osservazioni cliniche sull'azione pre-anestetica del cliradon (Clinical observations on the pre-anesthetic effects of cliradon). Gazzetta m?dica italiana, 1953, 112:8, p. 203-206

CURRY, J. J.: Clinical appraisal of demerol, benadryl and pyribenzamine. Medical Clinics of North America, 1946, 30, p. 1138-1148;

--: Habituation to meperidine hydrochloride (Demerol hydrochloride). Journal of the American Medical Association, 1947, 133:4, p. 243-244

CYRAN, W.: Erfahrungen mit der intraven?sen Dolantin-Evipannarkose (Experiments with intravenous dolantin-evipan anesthesia). Aerztliche Wochenschrift, 1952, 7:44, p. 1036-1038

D

DAURI, A.: PAOLETTI, G.: II Dolantin, analgesico di mantenimento in anestesia generale (Dolantin, adjuvant analgesic in general anesthesia). Minerva chirurgica, 1952, 7:11, p. 438-446

DIVIS, J.; KV?TOI, J.: Nase zkusenosti s Dolsinem za porodu (Application of dolosin in labor). Ceskoslovenska Gynaekologie, 1952, 17:9-10, p. 493-499

DOANE, J. C.: Meperidine hydrochloride (isonipecaine, demerol). Journal of the Albert Einstein Medical Center, 1953, 1:3, p. 106

DONATELLI, L.; BUFFONI, F.: Potenziamento della anestesia locale operato dalla mefedina (Augmenting effect of mefedine on action of local anesthetics). Archivo italiano di scienze farmacologiche, 1948, 1:2, (Ser. 2) p. 87-104

DOWNS, J. T.: Symposium on anesthesia. I. Obstetric use of demerol. Texas State Journal of Medicine, 1947, 43:8, p. 486-488

DUGUID, A. M. E.; HEATHCOTE, R. St. A.: The pharmacological action of ethyl-methylphenylpiperidine carboxylate. (Dolantal). Quarterly Journal of Pharmacy and Pharmacology, 1940, 13:4, p. 318-331

DUNDEE, J. W.: TINCKLER, L. F.: Pethidine and liver damage. British Medical Journal, 1952, 2:4786, p. 703-704

DUPRE, D. J.; ELKS, J.; HEMS, B. A.; SPEYER, K. N.; EVANS, R. M.: Analgesics. Part I. .Esters and ketones derived from &alpha-Amino-&omega-cyano-&omega&omega-diaryalkanes. Journal of the Chemical Society, 1949, p. 500-510

DUTTA, N. K.: Some pharmacological properties common to atropine, pethidine, procaine and quinidine. British Journal of Pharmacology and Chemotherapy, 1949, 4:2, p. 197-201

E

EISLEB, O.; SCHAUMANN, O.: Dolantin, ein neuartiges Spasmolytikum und Analgetikum (Dolantin, a new kind of spasmolytic and analgetic). Deutsche medizinische Wochenschrift, 1939, 65:24, p. 967-968

EISLEB, O.: U.S. Patent, No. 2,167,351, 25 July 1939, Piperidine compounds and a process of preparing them

German patent, No. 679,281, 3 August 1939. Verfahren zur Darstellung von Piperidinverbindungen (Process for preparation of piperidin compounds)

U.S. Patent, No. 2,242,575, 20 May 1941, Pentamethyleneoxide compounds and a process of preparing them

U.S. Patent, No. 2,248,018, 1 July 1941, 4-aryl-piperidine-ketones and a process of preparing them

German patent, No. 748,800, 10 November 1944, Verfahren zur Herstellung von 1-aryl-piperidin-4-carbons?urederivaten (Preparation of 1-arylpiperidine-4-carboxylic acid derivatives)

German patent, No. 752,755, 10 November 1952, Verfahren zur Herstellung von 1-Alkyl-4-( m-oxyphenyl)-piperidinverbindungen (Manufacturing process of compounds of 1-alkyl-4-( m-oxyphenyl) -piperidine)

ELLIOTT, H. W.: WARRENS, A. E.; JAMES, H. P.: Some effects of 1-methyl-4-phenyl-ethyl isonipecotate (demerol) and 6-di-methylamine-4,4-diphenyl-3-heptanone (amidone) upon metabolism of rat brain tissue in vitro. Journal of Pharmacology and Experimental Therapeutics, 1947, 91:2, p. 98-102

ERCOLI, N.; LEWIS, M. N.: Studies on analgesics. I. The time-action curves of morphine, codeine, dilaudid and demerol by various methods of administration. Journal of Pharmacology and Experimental Therapeutics, 1945, 84:4, p. 301-317

F

FEHER, V.; BRUTAR, V.: Uziti dolsinu pri porodu (Use of dolsin in labour) Ceskoslovensk? gynaekologie, 1953, 18:4, p. 360-372

FENSTER, M. N.: Nitrous oxide as an inhalation anesthetic. Journal of the Medical Society of New Jersey, 1951, 48:6, p. 281

FERRERO, F.: Esperienze cliniche sul "Cliradon" nella medicazione preanestetica (Clinical experience with cliradon in preanesthetic medication). Giornale italiano di anestesiologia, 1951, 17:3-4, p. 268-272

FINER, B. L.; PARTINGTON, M. W.: Pethidine and the triple response. British Medical Journal, 1953, 1:4807, p. 431-433

FINK, L. D.; AKIYAMA, J.: Response of the excised guinea pig tracheal muscle to morphine and meperidine. Archives internationales de pharmacodynamie et de therapie, 1952, 91:3-4, p. 322-329

FLATT, W. D.: The relief of pain in labour with demerol. Canadian Medical Association Journal, 1946, 55:1, p. 43-46

FLIPSE, M. E.; FLIPSE, M. J.: Hyperpyrexia due to demerol. Southern Medical Journal, 1949, 42:5, p. 395-401

FLOWERS, Jr., C. E.: Trilene, an adjunct to obstetrical anesthesia and analgesia. American Journal of Obstetrics and Gynecology, 1953, 65:5, p. 1027-1033

FORTI, D.: Procaine e dolantinici per via endovenosa in anestesia ed analgesia postoperatoria (Intravenous procaine and dolantin in anesthesia and postoperative analgesia). Minerva anestesiologica, 1953, 19:8, p. 216-217

FOSTER, R. H. K.; CARMAN, A. J.: Studies in analgesia: piperidine derivatives with morphine-like activity. Journal of Pharmacology and Experimental Therapeutics, 1947, 91:3, p. 195-209

FROHMAN, I. P.: Demerol, American Journal of Nursing, 1953, 53:5, p. 567-568

FUNKE, A.; JACOB, J.; DAENIKEN, K. von: Propri?t?s analg?siques et anticholinesterasiques du dichlorhydrate et du diiodom?thylate de la bis-(pip?ridinom?thyl-coumaranyl-5) c?tone. Comptes rendus hebdomadaires Acad?mie des sciences, 1953, 236:1, p. 149-151

G

GAENSLER, E. A.; MCGOWAN, J. M.; HENDERSON, F. F.: A comparative study of the action of demerol and opium alkaloids in relation to biliary spasm. Surgery, 1948, 23:2, p. 211-220

GAMMELTOFT, A.; JOHANSEN, S. H.; RUBEN, H.: Pethidin ved endoskopi gennem pharynx en ny analgesimetode for oesofagoskopi og gastroskopi (Pethidine in pharyngeal endoscopy; a new analgesic method in esophagoscopy and gastroscopy). Ugeskrift for Laeger, 1951, 113:17, p. 525-529; Pethidin ved cystoskopi; erfaringer med pethidin intraven?st ved endoskopi af urethra og blaere hos maend (Pethidine in cyostoscopy; experience with intravenous pethidine in endoscopy of male urethra and bladder). ibid. 1953, 115:39, p. 1448-1449

GARCIA, C. R.; WALTMAN, R.; LUBIN, S.: Continuous intravenous infusion of demerol in labor. American Journal of Obstetrics and Gynecology, 1953, 66:2 p. 312-318

GEBAUER, R.: German patent No. 739,952, 26 October 1943. Ver-fahren zur Herstellung von a-Piperidino-phenylessigs?ureamid (The preparation of a-piperidino-phenylacetic acid amide)

GELLER, W.: Ueber den Missbrauch starkwirkenden analgetica (Abuse of potent analgesics). Der Landarzt, 1952, 28:6, p. 147-149

GENTLING, A. A.; LUNDY, J. S.: A new analgesic AN-148: preliminary report. Proceedings of the Staff Meetings, Mayo Clinic, 1947, 22:13, p. 249-251

GESELLSCHAFT F?R CHEMISCHE INDUSTRIE: British patent No. No. 591,992, 22 June 1944. Manufacture of piperidine compounds

GILBERT, G.; DIXON, A. B.: Observations on demerol as an obstetric analgesic. American Journal of Obstetrics and Gynecology, 1943, 45:2, p. 320-326

GRANT, A. P.; MCNEILLY, J, W.: Treatment of tetanus with intravenous thiopentone and pethidine. Irish Journal of Medical Science, 1953, 6:329, p. 212-217

GRIFFITHS, H. F.; Pethidine as an adjunct to nitrous oxide and oxygen anaesthesia. British Medical Journal, 1950, 2:4682, p. 763-764

GRIGGS, T.: ADRIANI, J.: BERSON, W.: Aids to pediatric anesthesia. Current researches in anesthesia and analgesia, 1953, 32:5, p. 340-349

GROSS, E. G.; HOLLAND, H. L.; SCHUELER, F. W.: Human studies on analgesic piperidine derivatives. Journal of Applied Physiology, 1948, 1:4, p. 298-303

GROSS, F.; MEIER, R.: 1-Methyl-4- m-oxyphenyl-piperidin-4-?thylketon (Cliradon), ein neues synthetisches Analgeticum mit morphin?hnlicher Wirkung (A new synthetic analgesic with morphine-like activity, 4- ( m-hydroxyphenyl)-;-methyl-4-propio-nylpiperidine (Cliradon). Schweizerische medizinische Wochenschrift, 1949, 79:48, p. 1154-1159

GRUBER, C. M.; HART, E. R.; GRUBER JR., C. M.: The pharmacology and toxicology of the ethyl ester of l-methyl-4-phenyl-piperidine-4-Carboxylic acid (Demerol). Journal of Pharmacology and Experimental Therapeutics, 194.1, 73:3, p. 319-334

GUTTMAN, S. A.: Caution in the administration of Demerol to patients with intracranial lesions. Journal of the American Medical Association, 1944, 124:3, p. 155-157

H

HAMBURGER, W.: Beobachtungen ?ber das Auftreten von Cliradonsucht (Observations on Cliradon addiction). Muenchener medizinische Wochenschrift, 1952, 94:18, p. 939-940

HAMRICK, L. W., Jr.: The use of demerol in obstetrics. Journal of Bowman Gray School of Medicine of Wake Forest College, 1946, 4:2, p. 55-62

HAPKE, F. B.; BARNES, A. C.: The obstetric use and effect on fetal respiration of nisentil. American Journal of Obstetrics and Gynecology, 1949, 58:4, p. 799-801

HARRIS, J. R.; HYDER, N.: The use of secobarbital sodium and mephenesin as an anesthetic for dogs; a preliminary report Journal of the American Veterinary Medical Association, 1953, 123:919, p. 297-298

HAXHOLDT, B. F.: Kvaelstofforilite pethidin anesthesi med flaxe diltil afslappelse (Nitrous oxide -, pethidine anesthesia with flaxedil for relaxation). Ugeskrift for Laeger, 1951, 113:17, p. 513-520

HELBING, W.; DIEGRITZ, H.: Geburtserleichterung durch Dolantin (Dolantin in obstetric analgesia). Zentralblatt f?r Gyn?kologie, 1952, 74:13, p. 491-498

HEPBURN, J.: Pethidine for asthma. British Medical Journal, 1945, I:No. 4387, p. 174

HERINGTON, G.: JAMES, E.: Continuous succinylcholine chloride with pethidine in abdominal surgery. British Medical Journal, 1953, No. 4831, p. 317-320

HERSCHFUS, J. A.; SALOMON, A.; SEGAL, M. S.: The use of demerol in patients with bronchial asthma. Annals of Internal Medicine, 1954, 40:3, p. 506-515

HIMMELSBACH, C. K.: Studies of the addiction-liability of Demerol (D-140). Journal of Pharmacology and experimental Therapeutics, 1942, 75:1, p. 64-68. Further studies of the addiction-liability of demerol. Journal of Pharmacology and Experimental Therapeutics, 1943, 79:1, p. 5-9

HOFFMAN, R.: Demerol, a new departure in analgesia: an evaluation of present therapeutic claims. Current Research in Anesthesia & Analgesia, 1943, 22:6, p. 335-349

HOFFMANN-LA ROCHE, Inc.: U.S. Patent No. 2,498,430, 21 February 1950, 1-methyl-4- p-Methoxyphenyl-4-propionoxy-piperidine hydrochloride, U.S. Patent No. 2,498,433, 21 February 1950, 1,3 dimethyl-4-propionoxy-4-phenyl-piperidine and acid addition salts thereof

HOUDE, R. W.; SEEVERS, M. H.; PURCELL, F.; IRWIN, S.: Effects of morphine, meperidine, and methadone on the reflex reaction times of spinal animals. Journal of Pharmacology and Experimental Therapeutics, 1950, 98:1, p. 14

HUNT, A. B.: The use of demerol for obstetric analgesia. Minnesota Medicine, 1946, 29:3, p. 266-267

I

I. G. Farbenindustrie: Swiss patent, No. 218,517, 1 April 1942, Verfahren zur Herstellung von 1-methyl-4-phenyl-piperidyl-4-isopropyl. Keton (Preparation of 1-methyl-4-phenyl-piperidyl-4-isopropyl ketone); Swiss patent, No. 222,484, 16 October 1942, Verfahren zur Herstellung von 1-methyl-4-phenyl-piperidyl-4-propyl-keton (Preparation of 1-methyl-4-phenyl-piperidine-4-propyl-ketone); Swiss patent, No. 222,485, 16 October 1942, Ver-fahren zur Herstellung von 1-methyl-4-phenyl-piperidyl-4-isobutyl-keton (Preparation of 1-methyl-4-phenyl-piperidine-4-isobutyl ketone); French Patent, No. 897,453, 22 mars 1945, Proc?d? de preparation de compos?s appartenant ? la s?rie de la 4- ( m-hydroxy-phenyle) -piperidine

IRWIN, S.; HOUDE, R. W.; BENNETT, D. R.; HENDERSHOT, L. C.; SEEVERS, M. H.: The effects of morphine, methadone and meperidine on some reflex responses of spinal animals to nociceptive stimulation. Journal of Pharmacology and Experimental Therapeutics, 1951, 101:2, p. 132-143

ISBELL, H.: The addiction-liability of some derivatives of meperidine. Journal of Pharmacology and Experimental Therapeutics, 1949, 97:2, p. 182-189

IZOSIMOV, V. V.: Izuchenie novovo boleutoliaiushchevo sredstva: Promedol khirurgicheskoii praktike (Study of a new analgesic: Promedol in practical surgery). Klinicheskaia meditsina, 1952, 30:8, p. 63-65

J

JACQUENOUD, P.: L'association protoxyde d'azotedolosal. Anesth?sie et analg?sie, 1952, 9:4, p. 473-488

JAVERT, C. T.; HARDY, J. D.: Influence of analgesics on pain intensity during labor. Anesthesiology, 1951, 12:2, p. 189-215

JENSEN, K. A.; U.S. Patent No. 2,589,943, 18 March 1952, 4-Aryl-4-acyl-oxy-piperidines

JENSEN, K. A.; LUNDQUIST, F.; REKLING; WOLFFBRANDT, C. G.: En ny type piperidinderivater med analgetisk og spasmolytisk virkning. (A new type of piperidine derivative with analgetic and spasmolytic action). Dansk tidskrift for Farmaci, 1943, 17:18, p. 173-182; Chemical Abstracts, 1945, 39:11, p. 2506; Chemisches Zentralblatt, 1944, I, 115:5, p. 297-298

JOHNSON, P. D.: Pethidine as an adjuvant to nitrous oxide and oxygen anaesthesia. British Medical Journal, 1951, No. 4733, p. 705-707

JOHNSTONE, M.: Pethidine and general anaesthesia. British Medical Journal, 1951, 2:2, p. 943-946

K

KAEGI, H.; MUSCHER, K.: German patent No. 843,548, 10 July 1952, Verfahren zur Herstellung von 4-Aryl-piperidin-4-carbon-s?ureestern (Preparation of 4-arylpiperidine-4-carboxylic acid esters). U.S. Patent No. 2,486,795, 1 November 1949, Preparation of 4-aryl-4-carbalkoxy-piperidines; German patent No. 842,641, 30 June 1952, Verfahren zur Herstellung von Pipe-ridyl ketonen (Preparation of piperidyl-cetones); U.S. patent No. 2,546,159, 27 March 1951. Preparation of piperidyl ketones

KANE, W. M.: The results of nisentil in 1,000 obstetrical cases. American Journal of Obstetrics and Gynecology, 1953, 65:5, p. 1020-1026

KEPES, E. R.: Effect of demerol on the cerebrospinal fluid pressure. Anesthesiology, 1952, 13:3, p. 281-286

KING, B. D.; ELDER, Jr., J. D.; DRIPPS, R. D.: The effect of the intravenous administration of meperidine upon the circulation of man and upon the circulatory response to tilt. Surgery, Gynecology and Obstetrics, 1952, 94:5, p. 591-597

KIRSCHBAUM, H.: Relief of pain in labor, Anesth?sie et analg?sic, 1951, 8:4, p. 717-723

*KOENIG, R.; MAGYAR, K.: (New analgesic compounds with morphine-like effects). Magyar kemiai foly?irat, 1950, 56, p. 77-81

*KRUGLIKOVA L'VOVA, R. P.: (Comparative study of promedol and morphine effects on intestinal organ reflexes). Farmakologiya i toksikologiya, 1953, 16:3, p. 8-11

KUNZ, T.: Die Dolantin-Evipan-Lachgas-narkose mit "My 301" als Muskelrelaxans (Dolantin-evipan nitrous oxide anesthesia with "My 301" as a muscle relaxant) Medizinische, 1953, No. 48, p. 1555-1556

KWARTLER, C. F.: U.S. patent No. 2,634,275, 7 April 1953, 4-acylamino-l-alkyl-4-phenylpiperidines and method of making same

L

LACOMME, M.; LABORIT, H.; LE LORIER, G.; POMMIER, M.: Note sur un essai d'analg?sie obstetricale potentialis?e par association de dolosal et de 45 - 50 R.P. en perfusion intraveineuse; ?tude de 175 cas. Bulletin de la f?d?ration des soci?t?s de gyn?cologie et d'obst?trique de langue francaise, 1952, 4:3bis, p. 558-562

LA FORGE, H. G.: Nisentil in 1,000 obstetric cases. New York State Journal of Medicine, 1951, 51:15, p. 1835-1838

LEE, J.; FREUDENBERG, W.: Piperidine derivatives, I. Lobelan and related compounds. Journal of Organic Chemistry, 1944, 9:6, p. 537-546

LEE, J.; ZIERING, A.; HEINEMAN, S. D.; BERGER, L.: Piperidine derivatives. II. 2-phenyl- and 2-phenylalkyl-piperidines. Journal of Organic Chemistry, 1947, 12:6, p. 885-893; Parts III and V: see under ZIERING, etc.; Part IV, see under BERGER, etc.

LEE, J.; BERGER, L.; ZEIRING, A. (Hoffmann La Roche): British Patent No. 629,196, 14 September 1949, Preparation of piperidine derivatives. German patent No. 818,803, 29 October 1951, Verfahren zur Herstellung von piperidin abk?mmlingen (Preparation of piperidine derivatives)

LEHMAN, R. A.; AITKEN, T.: Determination of demerol in urine with preliminary observations on its excretion in man. Journal of Laboratory and Clinical Medicine, 1943, 28:6, p. 787-793

LEISSEM, H.: Chirurgische Erfahrungen mit dem neuen synthe-tischen Analgeticum Cliradon (Surgical experiments with the new synthetic analgesic Cliradon). Muenchener medizinische Wochenschrift, 1951, 93:12, p. 604-606

LENAHAN, R. M.: Factors involved in the choice of premedication for anesthesia. New York State Journal of Medicine, 1946, 46:17, p. 1924-1928

LEWIS, J. R.: A study of the development of tolerance to the actions of 1-methyl-4- (3-hydroxyphenyl) -4-piperidyl ethyl ketone hydrochloride in dogs. Journal of Pharmacology and Experimental Therapeutics, 1949, 96:4, p. 410-415

--: Action of 1-methyl-4 (3-hydroxyphenyl) -4-piperidyl ethyl ketone on the gastro-intestinal tract. Proceedings of the Society for Experimental Biology and Medicine, 1949, 71:2, p. 300-303

LIEF, P. A.; BURNS, J. J.; PAPPER, E. M.; BERGER, B. L.; WOLLACK, A.; BRODIE, B. B.: Physiological disposition of meperidine (demerol) in man. Federation Proceedings, 1952, 11:1, p. 369

LINDER, F.; VOLLMAR, J.: Klinische Erfahrungen mit dem synthetischen Analgeticum Cliradon (Ciba 7115) mit vergleichenden Untersuchungen ?ber seine Wirkung auf Atmung, Kreislauf und W?rmehaushalt (Clinical experiences with the synthetic analgesic Cliradon (Ciba 7115): comparative experiments on its action on respiration, circulation and thermal balance). Klinische Wochenschrift, 1950, 28: 39/40, p. 675-681

LOESCHKE, H. H.; SWEEL, A.; KOUGH, R. H.; LAMBERTSEN, C. J.: The effect of morphine and of meperidine (dolantine, demerol) upon the respiratory response of normal men to low concentrations of inspired carbon dioxide. Journal of Pharmacology and Experimental Therapeutics, 1953, 108:3, p. 376-383

LONGO, V. G.; NAPOLITANO, L.: Action of analgesic drugs (morphine, meperidine, methadone) on rotatory nystagmus in the rabbit. Journal of Pharmacology and Experimental Therapeutics, 1953, 107:2, p. 154-159

LORENZINI, L.: II cliradon (chloridrato dell' 1-metil-4- ( m. ossifenil) -piperidin-4-etilchetone) nella preparazione all'anestesia (Cliradon (1-methyl-4- ( m-hydroxyphenyl) -4-piperidyl ethyl ketone hydrochloride) in preparation for anesthesia). Giornale italiano di anestesiologia, 1950, 16:3, p. 484-490

LOWY, P. H.: The conversion of lysine to pipecolic acid by Phaseolus vulgaris. Archives of Biochemistry and Biophysics, 1953, 47:1, p. 228-229

LUBIT, E. C.: Use of demerol hydrochloride in dentistry. Dental Items of Interest, 1949, 71:8, p. 814-817

LUND, C. J.: Choices of analgesics during the first stage of labor. Journal of the American Medical Association, 1951, 145:15, p. 1114-1118

Mc

MCDERMOTT, T. F.; PAPPER, E. M.: Respiratory complications associated with demerol. New York State Journal of Medicine, 1950, 50:14, p. 1721-1726

M

MANSON, W. W.: Demerol, scopolamine, and caudal analgesia. Results in 700 cases. United States Armed Forces Medical Journal, 1950, 1:12, p. 1437-1445

MARIANI M ARELLI, O.: Alterazione delle soluzioni di dolantina per azione del calore (Alterations in dolantin solutions due to the effect of heat). Rendiconti istituto superiore di sanita, 1951, 14:4, p. 282-286

MAXIMOV, A.: Demerol analgesia in obstetrics. California Medicine, 1946, 65:2, p. 43-47

MERENDINO, K. A.: Pharmacological aspects of gastric secretion. I. Effect of opium alkaloids and "allied" drug demerol on pouch secretions in dogs. Gastroenterology, 1948, 10:3, p. 504-511; IV. The effect of opium alkaloids and an "allied" drug demerol on gastric secretion in man, ibid. p. 522-531

MERGER, R.; MELCHIOR, J.: L'Analg?sie obst?tricale par l'association medicamenteuse: nembutal-dolosal-trilene. Bulletin de la f?d?ration des soci?t?s de gyn?cologie et d'obst?rique de language fran?aise, 1953, 5:3, p. 301-304

- ; LEVY, J.; BOURRICHON: Effets sur le travail de l'accouchement de l'association analg?sique nembutal-dolosal-trilene. Ibid., p. 304-306

MIESCHER, K.; KAEGI, H.: United States patent No. 2,486,792, 1 November 1949, 1-Alkyl-4- (meta-hydroxyphenyl) -4-carbaloxy-piperidines and their production

United States patent No. 2,846,793, 1 November 1949, Piperidine compounds and process of making same

United States patent No. 2,486,794, 1 November 1949, 1-Alkyl-4-(meta-hydroxyphenyl) -piperidyl-(4)- alkylketones and their production

United States patent No. 2,486,796, 1 November 1949, Estersol 1-Alkyl-4-hydroxyphenyl-piperidyl-4-ketones

United States patent No. 2,517,695, 8 August 1950. Production of 1-Alkyl-4-phenyl-piperidyl-4-ketones

United States patent No. 2,551,152, 1 May 1951, 4-Aryl-piperidyl-(4) -ketones

German patent, No. 850,005, 22 September 1952. Verfahren zur Herstellung von 4-Arylpiperidyl-(4)-ketonen und deren Abk?mmlingen (Preparation of 4-Arylpiperidyl-(4)-ketones and their derivatives)

MOGGIAN, G.: L'impiego del cliradon nella medicazione pre- e post-operatoria (Use of Cliradon in pre-operative and postoperative surgery). Annali di ostetricia e ginecologia, 1952, 74:11, p. 971-978

MORRISON, A. L.; RINDERKNECHT, H.: Synthetic analgesics. Part V. Compounds related to pethidine. Journal of the Chemical Society, 1950, p. 1467-1469

MUEHLAU, M.: Ist die Forderung berechtigt, die neuen stark wirkenden synthetischen Analgetica, insbesondere Polamidon, Cliradon, Dromoran, dem Opiumgesetz zu unterstellen? (On the inclusion of the new powerful analgesics, especially polamidon, cliradon and dromoran, among those drugs subject to the opium law). Aerztliche Wochenschrift, 1952, 7:11, p. 257-260

MUNDELL, M.: Report on demerol. Journal of the Association of Official Agricultural Chemists, 1945, 28:28, p.711-714

MURPHY, M.: Intravenous pethidine. Irish Journal of Medical Science, 1951, 6:311, p. 535-540

MUSHIN, W. W.; RENDELL-BAKER, L.: Pethidine as a supplement to nitrous oxide anaesthesis. British Medical Journal, 1949, 2:4625, p. 472; Intravenous pethidine and Flaxedil in anaesthesia for thoracic operations, British Journal of Anaesthesiology, 1950, 22:4, p. 235-239

N

NARODICK, B. G.; STEELE, J. D.: The use of demerol in patients sensitive to morphine. Anesthesiology, 1948, 9:3, p. 285-287

NAU, F.: Kritische Bemerkungen ?ber Ursachen, Verlauf und Bek?mpfung der Pervitin- und Dolantinsucht. (Critical remarks on the causes and course of Pervitin and Dolantin addiction; how to cure it). Jahreskurse f?r aerztliche Fortbildung, 1942, 33:2, p. 33-34

NAZAROV, I. N.; MASHBOVSKII, M. D.; RUDINKO, V. A. et al.: Novoe boleutoliaiushchee sredstvo: Promedol (A new analgesic: Promedol). Klinicheskaia meditsina, 1952, 30:8, p. 60-63

NEPOLA, S. R.: Clinical experience with demerol co-medication in dental local anesthesia. Oral Surgery, Oral Medicine and Oral Pathology, 1951, 4:4, p. 456-462

NOTH, P. H.; HECHT, H. H.; YONKMAN, F. F.: Demerol: a new synthetic analgetic, spasmolytic and sedative agent. II. Clinical observations. Annals of Internal Medicine, 1944, 21:1, p. 17-34 (For Part I, see under: YONKMAN, F. F., etc.)

O

OLEAGA, B. R.: Consideraciones sobre un nuevo analg?sico de s?ntesis (Considerations on a new synthetic analgesic). D?a m?dico, 1953, 25:88, p. 2456-2458

OPFER-SCHAUM, R.: Zum mikrochemischen Nachweis des Dolantins (Micro-chemical identification of dolantin). Oesterreichische Apotheker-Zeitung, 1952, 6:34/35, p. 543

O'REILLY, P. J.: Pethidine in obstetrics; review of 153 cases. Lancet, 1948, 2: No. 6539, p. 1012-1013

P

PATERSON, S. J.; PRESCOTT, F.: Nalorphine in the prevention of neonatal asphyxia due to maternal sedation with pethidine. Lancet, 1954, 266, No. 6810, p. 490-493

PAVLOVSKAIA, Z. N.: Obezbolivanie rodov tekodinom i lidolom (Anesthetized childbirth, using Tekodin [dihydrohydroxycodeinone hydrochloride] and lydol). Akusherstvo i ginekologiia, 1949, 6, p. 8-11

PEARCE, C.: Intravenous pethidine in anaesthesia; a report of 330 c?ses. British Journal of Anaesthesiology, 1951, 23:4, p. 205-213

PEREGALLI, P. F.: Ricerche sull'azione prenarcotica di un nuovo preparato analgesico di sintesi (prep. 7115, Cliradon Ciba) (Studies on pre-narcotic action of a new synthetic analgesic: Preparation 7115, Cliradon Ciba). Acta anaesthesiologica, 1952, 3:1, p. 47-51; Ricerche cliniche su un nuovo preparato analgesico di sintesi (prep. 7115-Cliradon Ciba) (Clinical research on a new synthetic analgesic: Preparation 7115, Cliradon Ciba). Minerva chirurgica, 1952, 7:7, p. 248-250

PERIA, G.; MIRABELLA, A.: La nostra esperienza con le anestesie potensializzate (Potentialized anesthesia). Minerva anestesiologica, 1953, 19:12, p. 321-330

PETERSEN, P. V.: Studies on a new spasmolytic compound 1,1-dyphenyl-3-dimethylaminobutene-1 ( A 29) related to methadone, and on the combined use of this compound and a potent analgesic, ketobemidone (A 21). Acta pharmacologica et toxicologica, 1951, 7:1, p. 51-64

PFEFFER. R. B.; STEPHENSON, JR., H. E.; HINTON, J. W.: The effect of morphine, demerol and codeine on serum amylase values in man. Gastroenterology, 1953, 23:3, p. 482-486

PHARMACOPOEIAS:

  1. - British, 1953, p. 409 (Pethidine)

  2. - Danica, 9th edition, 1948, p. 591 (pethidin)

  3. - French (Codex fran?ais), 7th ed. 1949, p. 559 (pethidine)

  4. - Internationalis , 1951, Vol. I, Engl. ed. p. 178-179

  5. - United States of America, 14th revision, 1950, p. 339 (meperidine)

  6. - USSR (Gosudarstvennaia farmakopeia Soiuza Sovetskikh sotsialisticheskikh Respublik), 8th ed., 1952, Add. I, p. 36-37 (Lydolum)

PICKERING, R. W.; ABREU, B. E.; BOHR, D. F.; REYNOLDS, W. F.: Some effects of meperidine on gastro-enteric, extra-hepatic biliary, and cardio-vascular activity. Journal of the American Pharmaceutical Association, (Scientif. ed.) 1949, 38:4, p. 188-192

PINKERTON, H. H.: General anaesthesia in collapse therapy for pulmonary tuberculosis. Anaesthesia, 1952, 7:2, p. 99-103

PITTINGER, C. B.; MOYERS, J.; CULLENS, S. C.; FEATHERSTONE, R. M.; GROSS, E. G.: Clinicopathologic studies associated with xenon anesthesia. Anesthesiology, 1953, 14:1, p. 10-17

PLOTNIKOFF, N. P.: Distribution of C 14labeled meperidine in the albino rat. Federation Proceedings, 1950, 9:1, p. 308; Journal of Pharmacology and Experimental Therapeutics, 1951, 101:1, p. 31;

- ; ELLIOTT, H. W.; WAY, E. L.: The metabolism of N-C 14H 3labeled meperidine. Journal of Pharmacology and Experimental Therapeutics, 1952, 104:4, p. 377-386

POWERS, B. R.: Observations on the use of "demerol". Southern Medical Journal, 1947, 40:10, p. 870-874

PRESTON, F. S.: Anaesthesia for mitral valvotomy. British Journal of Anaesthesia, 1953, 25:4, p. 299-314

PAYOR, W. J.: Pethidine in anaesthesia. New Zealand Medical Journal, 1953, 52:291, p. 398-400

Q

QUASTEL, J. H.: Biochemical aspects of narcosis. Current Re-searches in Anesthesia and Analgesia, 1952, 31:3, p. 151-163

R

RADOFF, L. M.; HUGGINS, S. E.: Protective action of N-allylnor-morphine against demerol. Proceedings of the Society for Experimental Biology and Medicine, 1951, 78:3, p. 879-880

RANDALL, H. S.; BELTON, M. K.; LEIGH, M. D.: Continuous infusion of demerol during anaesthesia. Canadian Medical Association Journal, 1952, 67:4, p. 311-313

RANDALL, L. O.; LEHMAN, G.: Pharmacological studies on analgesic piperidine derivatives. Journal of Pharmacology and Experimental Therapeutics, 1948, 93:3, p. 314-328

RATHGEB, F.: Swiss patent No. 277,304, 16 November 1951, Ver-fahren zur Herstellung von 1-methyl-piperidin Verbindungen (Process of manufacture of l-methyl-piperidine compounds)

ROBERTS, H.: Pethidine and scopolamine in labour. British Medical Journal, 1948, 2: No. 4577, p. 590-593

ROBY, C.; SCHUMANN, W. R.: Demerol (S-140) and scopolamin in labor. American Journal of Obstetrics and Gynecology, 1943, 45:2, p. 318-319

RODRIGUEZ, M. I.; BALESTIE, I.: Contribucion al estudio qu?-mico funcional de analgesicos sint?ticos de acci?n similar a la morfina. (Contribution to the chemico-functional study of synthetic analgesics with morphine-like action). Anales de la asociaci?n de qu?mica y farmacia del Uruguay, 1951, 51:2, p. 43-48

ROMANOFF, A.: Demerol habituation in bronchial asthma with report of a case. Annals of Allergy, 1951, 9:1, p. 95-96

ROSENFELD, S. S.; LAPAN, B.; WEINSTEIN, M. S.: Continuous intravenous drip of meperidine and scopolamine for relief of pains of labor. Bulletin of the New York Academy of Medicine, 1952, 28:8, p. 545

RUBEN, H.; ANDREASSEN, A. K.: Pharmacological effects of pethidine on the larynx seen during intubation. British Journal of Anaesthetics, 1951, 23:1, p. 33-38

- ; GAMMELTOFT, A.: Intravenous pethidine for oesophagoscopy and gastroscopy. Anaesthesia, 1953, 8:3, p. 194

RUCKER, E.: Intravenous anesthesia for obstetrical delivery. Journal of the Medical Association of the State of Alabama, 1953, 23:3, p. 59-64

RUSTIA, G.; ALMEDA, L.: Demerol and scopolamine in obstetrics. Journal of the Philippine Medical Association, 1948, 24:2, p. 61-65

RYPDAL, A.: Pethidin ved oesophagoskopi og bronchoskopi (Pethidine in oesophagoscopy and bronchoscopy). Tidskrift for den norske laegeforening, 1953, 73:21, p. 809-812

S

SANCHEZ HERNANDEZ, J. A.: Observaciones sobre el empleo del sedol y del Demerol en anestesia general (Sedol and meperidine as pre-anesthetics). Medicina, (Mexico),1949, 29:589, p. 390-396

SANFILIPPO, G.: Senescenza e farmaci. V. L'andamento della glicemia dopo iniezione di dolantin nel cane; influenza della dose e della eta (Senescence and drugs. V. Increase of gly-cemia after injection of dolantin in dogs; influence of dosage and age). Bollettino della societa italiana di biologia speri-mentale, 1952, 28:2, p. 210-212; VI. L'azione del dolantin, l'assuefazione a questa sostanza e i fenomeni di astinenza nel cane vecchio (VI. Action of dolantin, habituation to this substance and the phenomenon of abstinence in old dogs): Ibid., p. 212-214; Ricerche farmacologiche sul dolantin. I. L'azione del dolantin nel cane giovanissimo (Pharmacological research on dolantin. I. Action of dolantin in very young dogs). Ibid., p. 214-216; II. L'assuefazione e i fenomeni di astinenza da dolantin nel cane giovanissimo (II. Habituation and the phenomenon of abstinence from dolantin in very young dogs) . Ibid., p. 216-217; L'azione del dolantin nelle diverse fasi della vita (Effect of dolantin in the various phases of life). Archivio italiano di scienze farmacologiche, 1953, 3:3, p. 229-240

SATTES, H.: Cliradon als Suchtmittel (Cliradon, addiction-drug). Deutsche medizinische Wochenschrift, 1951, 76:46, p. 1464-1466

SCHACHTER, M.: The release of histamine by pethidine, atropine, quinine, and other drugs. British Journal of Pharmacology and Chemotherapy, 1952, 7:4, p. 646-654

SCHAUMANN, O.: Die neuen synthetischen Analgetika (The new synthetic analgesics). Oesterreichische chemiker Zeitung, 1952, 53: p. 225-233; also in Archiv f?r experimentelle Pathologie und Pharmakologie, 1952, 216:1-2, p. 48-77

SCHNECK, J. M.: A case of addiction to Demerol. Bulletin of the Menninger Clinic, 1944, 8:4, p. 122

SCHUMANN, W. R.: Demerol (S-140) and scopolamine in labor. A study of 1,000 cases. American Journal of Obstetrics and Gynecology, 1944, 47:1, p. 93-104

SCOTT, C. C.; ROBBINS, E. B.; CHEN, K. K.: Comparison of some new analgesic compounds. Science, 1946, 104:2712, p. 587-588

SENEQUE, J.; HUGUENARD, P.: Gangr?ne des doigts apr?s injection paraveineuse de piridosal-di?thazine. Anesth?sie et analg?sie, 1953, 10:4, p. 627-631

SHASS, E. IU.: Lidol (Lydolum). Feldsher i akusherka, 1953, No. 3, p. 51

SIGIDIN, IA. A.: O boleutoliaiushchem preparate promedole (The analgesic preparation promedol). Sovietskaia meditsina, 1953, 17:10, p. 25-27

SLAVIN, M. I.: Demerol premedication in the ambulatory patient. Oral Surgery, Oral Medicine and Oral Pathology, 1950, 3:9, p. 1159-1167

SLUTZKY, B.: Demerol as an analgesic. Nebraska State Medical Journal, 1947, 32:7, p. 277-279

STAHNKE, H. L.: Demerol® as an anti-scorpion therapeutic agent. Arizona Medicine, 1954, 11:2, p. 51-52

STEELE, C. W.: A comparison of the antidiuretic effect of de-merol and of methadon on mercurial diuresis in congestive heart failure; a case report. Journal of the Maine Medical Association, 1949, 40:10, p. 277-281

STEINMANN, W.: Geburtsbeschleunigung durch ein synthetisches Spasmolytikum (Efosin) (Acceleration of delivery by means of a synthetic spasmolytic). Die Medizinische, 1953, No. 39, p. 1274-1276

STRAZA, Jr., J. A.: Demerol and barbiturate poisoning. Journal of the Medical Society of New Jersey, 1949, 46:3, p. 136-138

T

TAINTER, M. L.: Estudio comparativo de algunas acciones del demerol y del metadon (Comparative study of some aspects of the action of demerol and methadone). Boletin de la asociacion medica de Puerto Rico, 1948, 40:1, p. 1-14;

- ; BUCHANAN, O. H.: A comparison of certain actions of demeol and methadene. California Medicine, 1949, 70:1, p. 35-43

TAYLOE, J. C.: Demerol-scopolamine analgesia in labor. North Carolina Medical Journal, 1947, 8:2, p. 86-87

TEARE, F. W.; HUSTON, M. J.: Effect of certain drugs on skeletal muscle. Archives internationales de pharmacodynamie et de therapie, 1953, 95:3-4, p. 437-443

THELEN, C.: Nisentil - a new analgesic drug for use in obstetrics. Jackson Clinic Bulletin, 1949, 11:6, p. 170-172; The use of Nisentil as an analgesic agent in obstetrics, ibid., 1950, 12:4, p. 119-121

THIGPEN, F. B.; THIGPEN, C. H.; CLECKLEY, H. M.: USE OF electric-convulsive therapy in morphine, meperidine and related alkaloid addictions. A.M.A. Archives of Neurology and Psychiatry, 1953, 70:4, p. 452-458

THORP, R. H.; WALTON, E.: Search for new analgesics. Part II. Further homologues of pethidine and the pharmacology of these and other compounds. Journal of the Chemical Society, 1948, p. 559-561

TURNER, A. K.: Demerol analgesia in labor combined with spinal anesthesia for vaginal delivery: report of one thousand cases. Journal of the Tennessee State Medical Association, 1946, 39:9, p. 314-316

V

VARA, P.; KINNUNEN, O.: Cliradonista gynekologin nakokannalta katsottuna (Use of cliradon in gynecology). Duodecim (Hel-sinki), 1951, 67:4, p. 326-329; Ueber den Gebrauch von Dolantin in der Obstetrik (Use of dolantin in obstetrics). Annales chirurgiae et gynaecologiae Fenniae, 1951, 40:4, p.216-227

VERSHININ, N. V.: Lidol (Lydolum), p. 84 of " Pharmakologia", published by Medgiz, Moscow, 1952, 475 pp.

VIDIC, E.: Der Nachweis von Polamidon und Dolantin im Urin und ihre Trennung von Morphin (Determination of pola-midon and dolantin in the urine and their separation from morphine). Archiv f?r experimentelle Pathologie und Pharmakalogie, 1951, 212:5-6, p. 339-351; Nachweis, Unterschei-dung und quantitative Bestimmung stark wirkender synthetischer Analgesica, insbesondere des Cliradons, im Urin (Detection, differentiation and quantitative determination of strong analgesics, especially cliradon in urine) Arzneimittel-Forschung, 1953, 3:1, p. 34-41

- ; BREINLICH, J.: Zum mikrochemischen Nachweis von Cliradon und Dromoran im Urin (Microchemical determination of Cliradon and Dromoran in urine). Arzneimittel-For-schung, 1953, 3:9, p. 490-491

VILLA, L.: Ricerche cliniche su un nuovo analgesico di sintesi (Cliradon). (Clinical research on a new synthetic analgesic: Cliradon). Gazzetta medica italiana, 1951, 110:7, p. 222-231

VOTAVA, Z.; HOR?KOV?, Z.: Experiment?ln? srovn?n? analgetisk?ho ?cinku morfinu, Dolsinu a Mecodinu (Comparison of the analgesic effect of morphine, methadone and demerol). Ceskosvlovensk? farmacie, 1952, 1, p. 338-347

W

WALTON, E.; GREEN, M. B.: Search for new analgesics. Part I. Homologues of pethidine and related compounds. Journal of the Chemical Society, 1945, p. 315-319

WAY, E. L.: Studies on the local anesthetic properties of isonipecaine. Journal of the American Pharmaceutical Association ( scient. ed.), 1946, 35:2, p. 44-47

- ; GIMBLE, A. I.; MCKELWAY, W. P.; ROSS, H.; SUNG, C. Y.; ELLSWORTH, H.: The absorption, distribution, and excretion of isonipecaine (Demerol). Journal of Pharmacology and Experimental Therapeutics, 1949, 96:4, I, p. 477-484

- ; SWANSON, R.; GIMBLE, A. I.: Studies in vitro and in vivo on the influence of the liver on isonipecaine (Demerol) activity. Ibid., 1947, 91:2, p. 178-184

WELLCOME FOUNDATION LTD.: British patent, No. 592,016, 1 February 1946, Improvements relating to the synthesis of derivatives of piperidine

WENDEL, H.; LOESCHKE, H. H.; SWEEL, A.; KOUGH, R. H.; LAMBERTSEN, C. J.: Effect of morphine and of meperidine upon the respiratory response of normal men to low concentrations of inspired carbon dioxide. Federation Proceedings, 1953, 12:1, I, p. 380 (No. 1252)

WINTERS, H. S.; GARCIA, C. R.; LUBIN, S.: Intravenous demerol in the second stage of labor. American Journal of Obstetrics and Gynecology, 1951, 61:3, p. 629-634

WINTHROP-STEARNS: Demerol hydrochloride, New York, 1951, 42 pp.

WOLFERS, P.: Intravenous pethidine in anaesthesia. British Journal of Anaesthesia, 1953, 25:3, p. 244-252

WOLFF, P. O.: On pethidine and methadone derivatives. Bulletin of the World Health Organization, 1949, 2:2, p. 193-204

WOOLFE, G.; MACDONALD, A. D.: The evaluation of the analgesic action of pethidine hydrochloride (demerol). Journal of Pharmacology and Experimental Therapeutics, 1944, 80:3, p. 300-307

WYLIE, W. D.: Some aspects of anesthesia for neurosurgery, with special reference to pethidine hydrochloride. Giornale italiano di anestesiologia, 1951, 17:3-4, p. 305-308

Y

YONKMAN, F. F.: Pharmacology of demerol and its analogues. Annals of the New York Academy of Sciences, 1948, 51:1, p. 59-82

YONKMAN, F. F.; NOTH, P. H.; HECHT, H. H.: Demerol, a new synthetic analgetic, spasmolytic and sedative agent. I. Pharmacological studies. Annals of Internal Medicine, 1944, 21:1, p. 7-16 (for Part II, see under: NOTH, etc.)

Z

ZIERING, A.; BERGER, L.; HEINEMAN, S. D.; LEE, J.: PIPERIDINE derivatives. III 4-arylpiperidines. Journal of Organic Chemistry, 1947, 12:6, p. 894-903 (for Part I, see under: LEE, J., etc.)

ZIERING, A.; LEE, J.: Piperidine derivatives. V. 1,3-Dialkyl-4-Aryl-4-acyloxypiperidines. Journal of Organic Chemistry, 1947, 12:6, p. 911-914

ZUCK, D.: A case of pethidine sensitivity . British Medical Journal, 1951, No. 4698, p. 125