SYNTHETIC DRUGS

Title

SYNTHETIC DRUGS

Sections

Part III METHADONE AND RELATED COMPOUNDS
Part IV MORPHINAN AND MORPHINE SYNTHESIS
Part V DITHIENYLBUTENYLAMINES

Details

Pages: 77 to 86
Creation Date: 1954/01/01

Bibliography

SYNTHETIC DRUGS

Part III. METHADONE AND RELATED COMPOUNDS Part IV. MORPHINAN AND MORPHINE SYNTHESIS Part V. DITHIENYLBUTENYLAMINES

Part III METHADONE AND RELATED COMPOUNDS

A

ABREU, B. E.; LIDDLE, G. W.; BURKS, A. L.; SIMON, A.; SUTHERLAND, V.; GORDON, G. S.: Effects of amphetamine, dihydroegotamine, 1-methadon on human central blood flow and oxygen uptake. Federation Proceedings. March 1948, 7:I, p. 201

ADLER, T. K.; EISENBRANDT, L. L.: The initial uptake of C 14-1abelled methadone by rat tissues. Proceedings of the Society for Experimental Biology and Medicine, 1949, 72:2, p. 347-349 (No. 17427)

ANONYMOUS: Amidone may excel morphine as agent for relief of pain. Drug Trade News, 2 June 1947, p. 35, 59

-----: Addiction liability of methadone. Journal of the American Medical Association, 1949, 140:6, p. 542

-----: Methadone. Army develops perfect substitute for morphine. Delaware State Medical Journal, 1951, 23:1, p. 20, 23

ANSLINGER, H. J.: Methadon addiction (correspondence). Journal of the American Medical Association, 1948, 138:8, p. 609

ATTENBURROW, J.; ELKS, J.; HEMS, B. A.; SPEYER, K. N.: Analgesics. II. The synthesis of amidone and some of its analogues. Journal of the Chemical Society, 1949, p. 510-518 (No. 114)

B

BACHELOR, A. L.; ELLIOTT, H. W.: The action of methadon upon the respiration of rat diaphragm and liver and kidney cortex slices. Federation Proceedings, 1948, 7:I, p. 203-204

BAIZER, M. M.: Methadone chemistry: A review. Bulletin on Narcotics, 1935, 5:1, p. 32-43

BARNES, A. C.; HAKPE, F. B.; HOLZAEPFEL, J. H.: The fetal respiratory depressant effect of methidon (sic). Preliminary report. Health Center Journal (Ohio State University), 1947, 1: No. 1, p. 18-20

BASIL, B.; EDGE, N. D.; SOMERS, G. F.: The pharmacology of phenadoxone or DL-6-morpholino-4:4-diphenylheptan-3-one hydrochloride. British Journal of Pharmacology and Chemotherapy, 1950, 5:1, p. 125-141

BATTERMAN, R. C.; OSHLAG, A. M.; The effectiveness and toxicity of methadon. Federation Proceedings, 1948, 7:I, p. 206; also in Anesthesiology, 1949, 10:2, p. 214-222

BAUMHOFF, G.; SCHUERMEYER, A.: Polamidon als Spasmolyticum und Analgeticum (Polamidon as a spasmolytic and analgesic). Medizinische Klinik, 1950, 45:16, p. 489-494

BECKER, A. M.: Zur Suchtfrage bei neuen Analgeticis (6-Dimethylamino-4, 4-diphenyl-3-heptanon, 'Heptadon'). (Addiction-liability of new analgetics). Wiener medizinische Wochenschrift, 1951, 101:3, p. 50-53

BECKER, J.; WULFF, K. J.: Klinische Erfahrungen mit dem Analgeticum Amidon 'Höchst' (Clinical experience with the analgesic Amidon Höchst) Medizinische Klinik, 1949, 44:22, p. 705-707

BEECHER, H. K.; DEFFER, P. A.; FINK, F. E.; SULLIVAN, D. B.: Field use of methadone and levo-iso-methadone in a combat zone (Humbung-Hungnam, North Korea). U.S. Armed Forces Medical Journal, 1951, 2:9, p. 1269-1276

-----; KEATS, A. S.: Analgesic activity and toxic effects of acetyl-methadol isomers in man. Federation Proceedings, 1952, 11, p. 321-322

BERCEL, N. A.: Clinical trial of '10820', a new synthetic analgesic. Diseases of the Nervous System, 1948, 9:1, p. 15-18

BERGE, E.; MUELLER, H.: Narkose mit Polamidon bei Hunden (Narcosis of dogs with polamidon). Tierärztliche Umschau, 1949, 4, p. 372-377

BIETER, R. N.; HIRSCH, A.: Methadon in internal medicine. Annals New York Academy of Science, 1948, 51:1, p. 137-144

BOCKMUEHL, M.: German patent 870.700, 2 May 1942. Verfahren zur Herstellung von basischen Ketonen (synthesis of basic ketones)

-----; EHRHARDT, G.: (Hoechst v. Meister Lucius & Brüning, Frankfurt/M.) German patent 865.314, 5 Aug. 1941. Verfahren zur Herstellung von basischen Ketonen. (Manufacturing process of basic ketones). German patent 711.069, 11 September 1938. Verfahren zur Darstellung von basischen Estern (Manufacturing process of basic esters)

-----;-----:Ueber eine neue Klasse von spasmolytisch und analgetisch wirkenden Verbindungen. I. (A new class of compounds with spasmolytic and analgesic action). Julius Liebigs Annalen der Chemie, 1948, 561:1, p. 52-85

BREINLICH, J.: Zum mikrochemischen Nachweis einiger Analgetica, insbesondere von Polamidon und Ticarda (Höchst), Cliradon (Ciba), und Dromoran (Roche). (Microchemical determination of certain analgesics, particularly Polamidon, Ticarda, Cliradon and Dromoran). Pharmazie, 1952, 7:10, p. 694-695.

BRODE, W. R.; HILL, M. W.: The optical resolution of amidone. Journal of Organic Chemistry, 1948, 13:2, p. 191-193

BROWN, J. M.; VOLPITTO, P. P.: Effects of various amnesie regimens on the human maternal and fetal blood gases during parturition. Anesthesiology, 1950, 11:6, p. 651-660

BRYAN, D. I.; SMYTH, C. J.: A study of the analgesic and toxic properties of dolophine (6-dimethyl-amino-4.4-diphenyl-3-heptanone hydrochloride). A preliminary report. American Journal of Medicine. 1947, 3:1. p. 122

BUELL. M.; COPELAND, J. E.; BOYD. E. M.: On the mechanism of the antitussive action of amidone. Federation Proceedings, 1948, 7:I. p. 208

C

CAHEN, R. L.; EPSTEIN. H. J.; KREMENTZ, C. S.: The evaluation of the analgesic action of methadon isomers and other analgesics by a new rapid screening method. Journal of Pharmacology and Experimental Therapeutics, 1948, 94:3, p. 328-337

CHAMBERLIN, E. M.; TISHLER, M.: Process for preparing 2,2-diphenyl-3-methyl - 4 - dimethylamino - butyronitrile. U.S. patent 2,607,794, 19 August 1952

CHEN, K. K.: Pharmacology of methadon and related compounds. Annals New York Academy of Sciences, 1948, 51:1, p. 83-97

CHENEY, L. C.; SMITH, R. R.; BINKLEY, S. B.: Ketimines and acylketimines related to amidone. Journal o, the American Chemical Society, 1949, 71:1, p. 53-56

CHRISTENSEN, E. M.; GROSS, E.G.: Analgesic effects in human subjects of morphine, meperidine and methadon. Journal of the American Medical Association, 1948, 137:7, p. 594-598

CLARK, R. L. (Merck & Co., Rahway, N. J.) 3-Hydroxy-4,4-diphenyl-6-aminoheptanes. U.S. patent 2,565,592, 28 August 1951

COOK, L.; BONNYCASTLE, D. D.: Action of common analgetic materials on spinal reflexes. Federation Proceedings, 1951. 10:I, p. 289

COUNCIL ON PHARMACY AND CHEMISTRY: Methadon, generic term for 6-dimethylamino-l,4-diphenyl-3 - heptanone. (Later changed to methadone). Journal of the American Medical Association, 1947, 134:17, p. 1483; Ibid., 1948, 138:9, p. 651

CRONHEIM, G.; WARE, P. A.: The determination and the urinary excretion of 6-dimethylamino-4,4-diphenyl-3-heptanone hydrochloride (amidone). Journal of Pharmacology and Experimental Therapeutics, 1948, 92:1, p. 98-102

CUSIC, J. W.: An improvement on the process for making amidone. Journal of the American Chemical Society, l949, 71:10, p. 3546.

D

DAVID, N. A.; SEMLER, H. J.: L-isomethadone and morphine analgesia potentiation by dihydrogenated ergot alkaloids in the rat. Federation Proceedings, 1952, 11:I, p. 335-336

DAVIS, M. E.; ANDROS, G. J.; KING, A. G.: Use of methadone-scopolamine in obstetric analgesia. Journal of the American Medical Association, 1952, 148:14. p. 1193-1198

DEMONCEAU, J.: Contribution ? l'étude analytique de la méthadone. Journal de la Pharmacie de Belgique, 1952, 7:1, p. 36-44

DENTON, J. E.; BEECHER, H. K.: New analgesics. II. A clinical appraisal of the narcotic power of methadone and its isomers. Journal of the American Medical Association, 1949, 141:16, p. 1146-1153

-----; STRAUSS, O. H.; WADDELL, W. E.; BEECHER, H. K.: A comparison of side-actions and analgesic effects of morphine, amidone (4-4-diphenyl-6-dimethylamino-heptanone - 3) and its isomers in man. Federation Proceedings, 1948, 7:I, p. 214-215

DUPRE, D. J.; ELKS, J.; HEMS, B. A.; SPEYER, K. N.; EVANS, R. M.: Analgesics. I. Esters and ketones derived from α-amino- ω-cyano- ωω-diarylalkanes. (No. 113) Journal of the Chemical Society, 1949, 2, p. 500-510

E

EADIE, G. S.; BERNHEIM, F.; FITZGERALD, D. B.: The effect of methadon on the cholinesterase of the brain. Federation Proceedings, 1948, 7:I, p. 216; also in Journal of Pharmacology and Experimental Therapeutics, 1948, 94:1. p. 19-21 (The inhibition of the cholinesterase of rat brain by methadon)

EASTON, N. R.; FISH, V. B.: Synthesis of 5-dimethylamino-4,4-diphenyl-2-pentanol. American Chemical Society, 126th meeting, 12-17 September 1954, New York, N.Y. (Abstracts of papers, p. 27N).

-----; GARDNER, J. H.; STEVENS, J. R.: A new synthesis and confirmation of the structure of amidone, Journal of the American Chemical Society, 1947, 69:12, p. 2941-2942

-----; -----; EVANICK, M. L.; STEVENS, J. R.: Some isomers of amidone and related compounds. Ibid., 1948. 70:1, p. 76-78

EDDY, N. B.: A new morphine-like analgesic (Amidone, methadon, etc.). Journal of the American Pharmaceutical Association (pract. ed.), 1947, 8:11, p. 536-540

-----; MAY, E. L.; MOSETTIG, E.: Chemistry and pharmacology of the methadols and acetylmethadols. Journal of Organic Chemistry, 1952, 17:2, p. 321-326

-----; TOUCHBERRY, C. F.; LIEBERMAN, J. E.: Synthetic analgesics. I. Methadon isomers and derivatives. Journal of Pharmacology and Experimental Therapeutics, 1950, 98:2, p. 121-137

EHRHART, G.; SCHAUMANN, O.: Polamidon, ein neues, stark wirkendes Analgetikum (Polamidone, a new powerful analgesic). Medizinische Monatsschrift, 1949, 3:8, p. 605-606

EISENBRANDT, L. L.; ABDOU, I. A.; ADLER, T. K.: Biliary excretion and intestinal reabsorption of C 14-1abeled methadone hydrobromide. Federation Proceedings, 1949, 8:I, p. 288

-----; ADLER, T. K.; ELLIOTT, H. W.; ABDOU, I. A.: The role of the gastro-intestinal tract in the excretion of C 14-1abeled methadone by rats. Journal of Pharmacology and Experimental Therapeutics, 1950, 98:2, p. 200-205 ; also Ibid., p. 7 (abstract)

-----; ELLIOTT, H. W.: Comparative in vivo and in vitro effects of methadone upon the Q 02 of rat liver, kidney and jejunum. Journal of Pharmacology and Experimental Therapeutics, 1949, 97:1, p. 120-124

ELLIOTT, H. W.: Comparative effects of 1:l-diphenyl-1-(dimethyl-aminoisopropyl)-butanone-2 (10820), demerol, and morphine on the respiration of rat cerebral cortex slices. Federation Proceedings, 1947, 6:I, p. 327

-----; CHANG, N. H.; ABDOU, I. A.; ANDERSON, H. H.: The distribution of radioactivity in rats after administration of C 14-1abeled methadone. Journal of Pharmacology and Experimental Therapeutics, 1949, 95:4, p. 494-501

-----; SUTHERLAND, V. C.; BOLDREY, E. B.: Respiration of human brain slices and the effects of morphine and methadone on oxygen uptake. Federation Proceedings, 1949, 8:I, p. 288-289

-----; WARRENS, A. E.; JAMES, H. P.: Some effects of 1-methyl-4-phenyl-ethyl isonipecotate (Demerol) and 6-dimethylamino-4,4-diphenyl-3-heptanone (Amidone) upon the metabolism of rat brain tissue in vitro. Journal of Pharmacology and Experimental Therapeutics, 1947, 91:2, p. 98-102

ENGELS, E.; STRAKE, H.: Polamidon C und seine praktische Anwendung (Polamidon C and its practical use). Medizinische Klinik, 1952, 47:47, p. 1572-1574

EVERETT, F. G.: The local anesthetic properties of amidone (Dolophine). Anesthesiology, 1948, 9:2, p. 115-120

F

FARBWERKE HOECHST: Verfahren zur Herstellung von aktiven Hetero-cyclischen Derivaten des 4,4-diphenylheptanon (Synthesis of active hetero-cyclic derivates of the 4,4-diphenylheptanon). Austrian patent, 171.406, 15 November 1951

FINNEGAN, J. K.; HAAG, H. B.; LARSON, P. S.; DREYFUSS, M. L.: Observations on the comparative pharmacologic actions of 6-dimethylamino-4,4-diphenyl-3-heptanone (Amidone) and morphine. Journal of Pharmacology and Experimental Therapeutics, 1948, 92:3, p. 269-276

FLATAKER, L.; WINTER, C. A.: Comparison of heptazone (4,4-diphenyl-6-morpholinoheptanone-3-hydrochloride) with other analgesic drugs. Federation Proceedings, 1949, 8:I, p. 47

FRASER, H. F.; ISBELL, H.: Addiction potentialities of isomers of 6-dimethylamino-4-4-diphenyl-3 acetoxy-heptane (acetyl-methadol) (abstract). Journal of Pharmacology and Experimental Therapeutics, 1951, 101:1, p. 12; Actions and addiction liabilities of α-acetylmethadol in man, Ibid., 1952, 105:4, p. 458-465

-----; WIKLER, A.; EISENMAN, A. J.; ISBELL, H.: N-allylnormorphine in treatment of methadone poisoning in man. Report of two cases. Federation Proceedings, 1952, 11:I, p. 346-347

FREILING, W.: Polamidonismus (Polamidon-addiction). Polizeipraxis, 1952, 6:23/24, p. 246-247

FULTON, C. C.: The identification of methadon by microcrystals. United Nations document E/CN.7/117, 14 April 1948, p. 17-31

G

GAEDECKE, R.: Die derzeitige Beurteilung des zentralen Analgeticum Polamidon (Present knowledge of the central analgetic Polamidon). Medizinische Monatsschrift, 1952, 6:4, p. 214-218

GARDNER, J. H.; EASTON, N. R.; STEVENS, J. R.: Some new compounds related to Amidone. Journal of the American Chemical Society, 1948, 70:9, p. 2906-2908

GERO, A.: Steric considerations on the chemical structure and physiological activity of methadone and related compounds. Science, 1954, 199:3082, p. 112-114

GERCHOW, J.: Straf- und zivilrechtliche Komplikationen der 'iatrogen' Rauschgiftsucht (Complexities of penal and civil laws relating to drug addiction of medical origin). F.-W. Sammlung von Vergiftungsfallen. Archiv für Toxikologie, 1952, 14:3, p. 150-164

GINSBURG, D.; BAIZER, M. M.: Fluorene analog of amidone. Journal of the American Chemical Society, 1949, 71:4, p. 1500

GLAZEBROOK, A. J.: Clinical trials of analgeticum NU-896 and of amidone. Edinburgh Medical Journal, 1949, 56:5, p. 206-213

GREIG, M. E.: The inhibition of hexokinase by amidone (2-dimethyl-amino-4,4-diphenylheptanone-5-hydrochloride). Archives of Biochemistry, 1948, 17:1, p. 129-137

-----; HOLLAND, W. C.: Effect of the D- and L-isomers of isoamidone on the permeability of dog erythrocytes. Proceedings, Society for Experimental Biology and Medicine, 1949, 71:2, p. 189-192 (No. 17129)

-----; HOWELL, R. S.: Comparison of effects of D- and L-isomers of amidone and isoamidone on cholinesterase. Proceedings, Society for Experimental Biology and Medicine, 1948, 68:2, p. 352-354 (No. 16484) ; The inhibition by amidone 1,3 of pyruvate and succinate oxidation by rat brain and the reversal of the inhibition by boiled yeast extract. Archives of Biochemistry, 1948, 19:3, p. 441-448

GUTNER, L. B.; GOULD, W. J.; BATTERMAN, R. C.: Effects of potent analgesics upon vestibular function. Federation Proceedings, 1951, 10:I, p. 304

H

HALL, H. C.: Methadone, scopolamine, and nembutal anesthesia in fifteen dogs. Journal of the American Veterinary Medical Association, 1953, 122:913, p. 289-290

HEMS, B. A.; ELKS, J.: Improvements in and relating to the preparation of a new ketone having analgesic properties. British patent 627,286, 4 August l949; 4,4 - diphenyl - 6 - morpholino - heptanone-3 and acid salts thereof. U.S. patent 2.513.173, 27 June 1950

HENDERSON, F. G.; CHEN, K. K.: Effect of age upon toxicity of methadon. (No. 16483) Proceedings, Society for Experimental Biology and Medicine, 1948, 68:2, p. 350-351

-----; ROBBINS, E. B.; CHEN, K. K.: Action and toxicity of methadone in various animals. Archives internationales de pharmacodynamie et de thérapie, 1949, 79:2-3, p. 282-289

HERR, F.; PERSZASZ, H.: Ueber die Wirkung einiger Derivate des Polamidons 2-Dimethylamino-4,4-diphenylheptan-5-one (Effect of some derivatives of Polamidon). Archiv für experimentelle Pathologie und Pharmakologie, 1950, 210:3, p. 294-304

HEWER, A. J. H.; KEELE, C. A.: 'Miadone'. An analgesic drug (Höchst 10820). Lancet, 1947, 253:6469, p. 281

HILL, M.: 'Heptalgin' as an obstetric analgesic. Medical Journal of Australia, 1951, I, 38:6, p. 212-214

HOFFMANN, W.: Die Analytik des Polamidon (Analysis of Polamidon). Arzneimittel-Forschung, 1953, 3:7, p. 364-368;

-----: Der Nachweis des Polamidon in postonal Suppositorien (Detection of Polamidon in postonal suppositories). Ibid., 1953, 3:8, p. 440-441

HOPPE, J. O.; MILLER, L. C.: A comparison of the toxicity of methadon and some related compounds. Federation Proceedings, 1948, 7:I, p. 228

HOUDE, R. W.; SEEVERS, M. H.; PURCELL, F.; IRWIN, S.: Effects of morphine, meperidine, and methadone on reflex reaction time of spine animals (abstract). Journal of Pharmacology and Experimental Therapeutics, 1950, 98:1, p. 14

-----; WIKLER, A.; IRWIN, S.: Comparative actions of analgesics, hypnotics and paralytic agents in hindlimb reflexes in chronic spinal dogs. Ibid., 1951, 103:3, p. 243-248

HOUGS-OLSEN, W.: Comparative investigations into the analgesic effects of morphine and DL-6-dimethylamino-4,4-diphenyl - 3 - heptanone hydrochloride (Methadone, Butalgin). Acta pharmacologica et toxicologica, 1949, 5:1, p. 33-44

HOWE, E. E.; BROOK, B.; TISHLER, M.: Salts of D-amidone with an optically active acid and process for resolving DL-amidone. U.S. patent 2,644,010, 30 June 1953

-----; SLETZINGER, M.: Resolution of DL-methadone and DL-isomethadone, Journal of the American Chemical Society, 1949, 71:8, p. 2935-2936

I

IRWIN, S.; HOUDE, R. W.; BENNETT, D. R.: Effects of morphine, methadone, and meperidine in some reflex responses of spinal animals to nociceptive stimulation. Journal of Pharmacology and Experimental Therapeutics, 1951, 101:2, p. 132-143

ISBELL, H.: The newer analgesic drugs. Their use and abuse. Annals of Internal Medicine, 1948, 29:6, p. 1003-1013

-----; EISENMAN, A. J.: Physical dependence liability of drugs of the methadon series and of 6-methyldihydromorphine. Federation Proceedings, 1948, 7:I, p. 162.

-----; -----: The addiction liability of some drugs of the methadon series. Journal of Pharmacology and Experimental Therapeutics, 1948, 93:3, p. 305-313

-----; -----; WIKLER, A.; DAINGERFIELD, M.; FRANK, K.: Experimental addiction to '10820' (4-4-diphenyl-6-dimethylamino-heptanone-3) in man. Federation Proceedings, 1947, 6:1, part II, p. 264

-------; -------; -------; -------; -------:Treatment of the morphine abstinence with '10820' (4-4-diphenyl-6-dimethylamino-heptanone-3). Federation Proceedings, 1947, 6:II, p. 340-341

-----; -----; -----; FRANK, K.: The effects of single doses of 6-di-methylamino-4,4-diphenyl- 3 -heptanone (amidone, methadon, or '10820') on human subjects. Journal of Pharmacology and Experimental Therapeutics, 1948, 92:1, p. 83-89

-----; FRASER, H. F.: Human pharmacology and addiction liability of derivatives of 3-hydroxy-N-methyl-morphinan, Journal of Pharmacology and Experimental Therapeutics, 1951, 103:4, p. 348 (abstracts)

-----; -----: Addictive properties of methadone derivatives . Federation Proceedings, 1954, 13:I, p. 369-370

-----; VOGEL, V. H.: The addiction liability of methadon (amidone, dolophine, '10820') and its use in the treatment of the morphine abstinence syndrome. American Journal of Psychiatry, 1949, 105:12, p. 909-914

-----; WIKLER, A.; EDDY, N. B.; WILSON, J. L.; MORAN, C. F.: Tolerance and addiction-liability of 6-dimethylamino-4-4-diphenyl-heptanone - 3 (Methadon). Journal of the American Medical Association, 1947, 135:14, p. 888-894

-----; -----; EISENMAN, A. J.; DAINGERFIELD, M.; FRANK, K.: Liability of addiction to 6-dimethylamino-4-4-diphenyl-3-heptanone (Methadon, 'Amidone' or '10820') in man. Archives of Internal Medicine, 1948, 82:4, p. 362-392

-----; -----; -----; FRANK K.: Effect of single doses of '10820' (4-4-diphenyl-6-dimethylamino-heptanone-3) on man. Federation Proceedings, 1947 , 6:II, p. 341

ISHMAEL, W. K.; STACY, J. R.: The use of Dolophine (Dimethylamino-heptanone Methadon) in the control of pain in bone and joint disorders. Oklahoma State Medical Association Journal, 1947, 40, p. 454-456, 468; abstract in Journal of the American Medical Association, 1948, 136:11, p. 801

J

JAMES, H. P.; PAGE, E. W.: Influence of some analgetics of obstetrical importance upon the respiration of mature human placenta in vitro. Federation Proceedings, 1948 , 7:I, p. 230

JENNEY, E. A.; PFEIFFER, C. C.: Comparative analgesic and toxic effects of the optical isomers of methadon and isomethadon. Federation Proceedings, 1948, 7:I, p. 231

K

KAAE, S.: Butalgin, et nyt Analgeticum (A new analgesic, Butalgin). Nordisk medicin, 1948, 38:14, p. 684-687

KARR, N. W.: Effects of 6-dimethylamino-4,4-diphenyl-3-heptanone (Dolophin) on intestinal motility. Federation Proceedings, 1947, 6:II, p. 343

KEATS, A. S.; BEECHER, H. K.: Clinical evaluation of two new analgesics, heptazone and WIN-1161-2 as a test of a new method of measuring analgesic power. Federation Proceedings, 1950, 9:I, p. 290

-----; -----: Respiratory effects of some new analgesics. Ibid., 1951, 10:I, p. 313

-----; -----: Analgesic potency and side-action liability in man of Heptazone, WIN-1161-2, 6-methyl-dihydromorphine, Metopon, levo-isomethadone and pentobarbital sodium, as a further effort to refine methods of evaluation of analgesic drugs. Journal of Pharmacology and Experimental Therapeutics, 1952, 105:2, p. 109-129

-----; -----: Analgesic activity and toxic effects of acetylmethadol isomers in man. Ibid., 1952, 105:2, p. 210-215

KIMURA, K. K.; DEBOER, B.: Effect of analgesic compounds on blood sugar (abstract ). Journal of Pharmacology and Experimental Therapeutics, 1951, 101:1, p. 20

-----; -----: WALT, L.; KEITH, E.: Experimental tolerance to hyperglycemia produced in rabbits by analgesic compounds. Federation Proceedings, 1951, 10:I, p. 314

KIRCHHOF, A. C.; DAVID, N. A.: Clinical trial of a new synthetic heptanone analgesic (Dolophine). I. Preliminary report. Western Journal of Surgery, Obstetrics and Gynecology, 1947, 55:3, p. 183-186; also in Federation Proceedings, 1947, 6:II, p. 345

-----; -----: A clinical trial of amidone (Dolophine), a new synthetic analgesic. Current researches in Anesthesia and Analgesia, 1948, 27:2, p. 92-100

-----; -----: Clinical experience with methadon (Dolophine). Anesthesiology, 1948, 9:6, p. 585-593

-----; UCHIYAMA, J. K.: Spasmolytic action of 6-dimethylamino-4,4-diphenyl-3-heptanone (Dolophine), a synthetic analgesic. Federation Proceedings, 1947, 6:II, p. 345

KLEIDERER, E. C.; RICE, M. B.: CONQUEST, V.; WILLIAMS, J. H.: Pharmaceutical activities of the I. G. Farbenindustrie Plant, Höchst - am - Main. Office of the Publication Board, Department of Commerce, Washington, D. C., Report No. 981, July 1945

KNOBLAUCH, G.; KRAUSE, D.: Experimentelle und klinische Untersuchungen über die Wirkung des Polamidon beim Hund (Experimental and clinical investigations on the effect of Polamidone (methadone) on the dog). Tierärztliche Umschau, 1950, 5: p. 134-138; also in Chemiches Zentralblatt, 1950 II, 121:4, p. 438

KOHLSTAEDT, K. G.; CLOUSE, P.; LEE, W. V.; SCOTT, C. C.: Pharmacology and the clinical use of Dolophine (6-dimethylamino-4,4-diphenyl-3-heptanone (hydrochloride). American Journal of Medicine, 1947, 3:1, p. 122-123

KRAEMER, R.: Ein Beitrag zur Polamidonsucht (On addiction to Polamidone) Nervenarzt, 1952, 23:1, p. 33-34

KRAPCHO, J.: Synthetic analgesics. Cyclics analogs of amidone. University Microfilms (Ann Arbor, Michigan), Publication No. 2417, 110 pp. Microfilm Abstracts, 1951, 11:2, p. 264-266

KRAUSE, D.; RUHNAU, D.: Systemwirkungen des Polamidons (Systemic action of Polamoidone). N.S. Archiv für experimentelle Pathologie und Pharmakologie, 1952, 216:6, p. 541-551

L

LEIMBACH, D. G.; EDDY, N. B.: Synthetic analgesics. III. Methadols, isomethadols and their acyl derivatives. Journal of Pharmacology and Experimental Therapeutics, 1954, 110:2, p. 135-147

LEIMDORFER, A.: Influence of amidone, morphine and strychnine on the Straub tail-test of white mice. Federation Proceedings, 1948, 7:I, p. 239

LENDLE, L.: Pharmakologie der Rauschgifte und Betäubungsmittel (Pharmacology of intoxicants and narcotics). Oeffentlicher Gesundheitsdienst, 1950, 12:9, p. 372-386

LINDNER, E.: Ueber ein neues Analgeticum, Polamidon (Polamidon, a new analgesic) Süddeutsche ApothekerZeitung, 1949, 89:24, p. 449-451

LINZ, A.: Zur Frage der Polamidonsüchtigkeit (Of the addiction-liability of Polamidon). Berliner medizinische Zeitschrift, 1950, 1:23/24, p. 616-619

LONGO, V. G.; NAPOLITANO, L.: Action of analgesic drugs (morphine, meperidine, methadone) on rotary nystagmus in the rabbit. Journal of Pharmacology and Experimental Therapeutics, 1953, 107:2, p. 154-159

LUCAS, G. H. W.: Color and crystal tests for the identification of methadon and isomethadon. Federation Proceedings, 1949, 8:I, p. 317

LUDUENA, F. P.; MILLER, L. C.; ANANENKO, E.; FRICK, J. D.: Some pharmacological actions of isomers of methadon. Federation Proceedings, 1948, 7:I, p. 241-242

LUND, C. J.: Newer obstetric analgesics. Preliminary evaluation of compounds No. 10720 and No. 10820 (Dolophine). American Journal of Obstetrics and Gynecology, 1948, 55:6, p. 1007-1015

M

MAIER, S.: Ueber Polamidonmissbrauch (Of the abuse of Polamidon). Medizinische Monatsschrift, 1950, 4:8, p. 620-621

MAY, E. L.; EDDY, N. B.: The isomethadols and their acetyl derivatives. Journal of Organic Chemistry, 1952, 17:9, 1210-1215

MAY, E. L.; MOSETTIG, E.: Some reactions of amidone. Journal of Organic Chemistry, 1948, 13:3, p. 459-464; some reactions of isoamidone, Ibid., 1948, 13:5 , p. 663-665

MILLER, J. W.; ELLIOTT, H. W.: In vitro studies on the diphasic action of methadone. Federation Proceedings, 1953, 12:I, p. 351-352 (No. 1158); also in Journal of Pharmacology and Experimental Therapeutics, 1954, 110:1, p.106-114

MOHR, W.; BECKER, H.: Ueber die Verwendung des Polamidons in der inneren Medizin (Use of Polamidon in internal medicine). Medizinische Monatsschrift, 1950, 4:5, p. 363-367

MORRISON, A. L.; RINDERKNECHT, H.: Synthetic analgesics. Part IX. Synthesis of compounds related to amidone (No. 306). Journal of the Chemical Society, 1950, p. 1478-1481

MUELLER-LIMMROTH, H. W.; MASSMANN, H.: Der Einfluss des Polamidons auf das Elektroencephalogramm des Menschen (Effects of polamidone on the EEG of man). Klinische Wochenschrift, 1952, 30:39-40, p. 943-944

O

OFNER, P.; THORP, R. H.; WALTON, E.: A new analgesic drug analogous to isoamidone, Nature, 1949, 163:4143, p. 479

----; WALTON, E.; GREEN, A. F.; WHITE, A. C.: Search for new analgesics. Part IV. Variations in the basic side-chain of Amidone (No. 484). Journal of the Chemical Society, 1950, p. 2158-2166

OSTERWALD, K. H.: Zwei Beobachtungen von Atemlähmung nach Polami-donmissbrauch (Two observations of res-piratory paralysis after overdose of Pol-amidon). Sammlung von Vergiftungsfallen; Archiv für Toxikologie, 1953, 14:6, p. 349-351

P

PAGE, J. E.; KING, H.: The determination of phenodoxone in urine. The Analyst, 1950, 75:887, p. 71-73

PETERSEN, P. V.: Studies on a new spasmolytic compound 1,1-diphenyl-3-dimethylaminobutene-1 (A-29) related to methadone, and on the combined use of this compound and a potent analgesic, Ketobemidone (A-21). Acta pharmaco-logica et toxicologica, 1951, 7:1, p. 51-64

PFEIFFER, C. C.; JENNEY, E. H.; GERSCH, I.: Chronic intoxication of the central nervous system produced by the methadon side-chain. Federation Proceedings, 1948, 7:I, p. 248

PFISTER, K.: Process of separating isomers of amidone intermediates. U.S. patent 2,497,739, 14 February 1950

PHARMACOPOEIA: British, 1953, p. 342 (Methadone). Danica, 1948, 9th. ed. Add. 1951, p. 80 (Methadone). URSS Gosudarstvennaia farmakopeia (Soiuza Sovetskikh Sotsialisticheskikh Respublik), 1952, 8th ed., Add. I, p. 48-49 (Phenadonum)

PHATAK, N. M.; DAVID, N. A.: Addiction potentialities of some methadone analgesics and alpha-acetylmethadol as determined by their hyperglycemic responses in rabbits. Current Researches in Anesthesia and Analgesia, 1953, 32:4, p. 242-249; Effects of Hydergine (CCK No. 179) on the modification of tolerance to morphine and L-isomethadone hyperglycemia in rabbits. Journal of Pharmacology and Experimental Therapeutics, 1953, 109:2, p. 139-147

----; MALONEY, J.; DAVID, N.: Use of hyperglycemic response for estimating addiction-potentialities of analgesic compounds. Federation Proceedings, 1948, 7:1, p. 249

PIECK, K.: Gibt es eine Polamidonsucht? (Addiction to Polamidon?) Medizinische Klinik, 1950, 45:45, p. 1429-1432

POHLAND, A.; MARSHALL, F. J.; CARNEY, T. P.: Optically active compounds related to methadon. Journal of the American Chemical Society, 1949, 71:2, p. 460-462

POPKIN, R. J.: Experiences with a new synthetic analgesic, amidone; its action on ischemic pains of occlusive arterial diseases. American Heart Journal, 1948 , 35:5, p. 793-799

POWELL, C. E.; CHEN, K. K.: Action of dolophine on the animal uterus. Journal of the American Pharmaceutical Association, 1948, 37:12, p. 516-518

POWERS, B. R.: Use of methadone to combat withdrawal symptoms of 'dilaudid' addiction; case report. Journal of the Tennessee State Medical Association, 1949 , 42:3, p. 83-84

PRESCOTT, F.; RANSOM, S. G.: Amidone (Miadone) as an obstetric analgesic: trial in sixty-two cases. Lancet, 1947, 253:6475, p. 501-503

R

REID, Jr., W. B.; SCHNEIDER, A. W.: Process for preparing 4,4-diphenyl-6-dimethylamino-heptanone-3. U.S. patent No. 2,601,323, 24 June 1952

REMY, D.: Klinische Erfahrungen mit 'Polamidon' (Hoechst 10820). (Clinical experience with Polamidon (Hoechst 10820)). Deutsche medizinische Wochen-schrift, 1949, 74:27/28, p. 872-873; Ueber den Einfluss des Polamidon (Hoechst 10820) auf die Ventilations-steigerung nach CO 2-Atmung (Effect of Polamidon (Hoechst 10820) on rise in ventilation after CO 2-breathing). Klinische Wochenschrift, 1950, 28:17/18, p. 318-319

----; WOLSKY, H.: Der Einfluss von Polamidon (Hoechst 10820) im Vergleich zu Morphin, und Dolantin auf die Ventilationsgrösse unter Kohlensäu-reatmung (Effect of Polamidon (Hoechst 10820) compared with morphine and dolantine on the volume of ventilation under acid carbonic breathing). Therapie der Gegenwart, 1950, 89:2, p. 41-46

REUTNER, T. F.; GRUHZIT, O. M.: Methadon, a new analagesic. Study in combination with thiobarbiturate anesthesia in dogs. Journal of the American Veterinary Medical Association, 1948, 113:860, p. 448-451

RICKARDS, J. C.; BOXER, G. E.; SMITH, C. C.: Studies on the distribution, and metabolism of methadone in normal and tolerant rats by a new colorimetric method. Journal of Pharmacology and Experimental Therapeutics, 1950, 98:4 (I), p. 380-391

RIEBELING, C.: Bemerkungen zur Polamidontherapie (Remarks on Polamidon therapy). Deutsche medizinische Wochenschrift, 1950, 75:27/28, p. 946-948

RIESS, O.: Ueber Schmerzbekämpfung mit Polamidon und die Gefahren seines Missbrauches (Pain soothing with Polamidon and perils of its misuse) Arzt und Patient, July 1950, 63, p. 13-14

ROBBINS, B. H.: Clinical observations on the use of amidone for analgesia. Anesthesiology, 1949, 10:3, p. 280-288

S

SALM, H.: Beobachtungen bei Polami-donsüchtigen, insbesondere über psychische Veränderungen nach Polamidonmissbrauch (Observations on polamidon addicts, especially on psychic changes after misuse of Polamidon). Nervenarzt,1953, 24:4, p. 143-148

SALVESEN, B.: Methadon, Fargereaksjoner og fotometrisk bestemmelse (Colour and photometric reactions of methadone). Meddelelser fra norsk farmaceutisk selskap, 1952, 14:1, p. 1-11

SATTES, H.: Ueber Polamidonsucht (Polamidon addiction). Deutsche medizinische Wochenschrift, 1950, 75: 19, p. 638-641; Zur Polamidonsucht (Polami-don addiction), Ibid., 1951, 76:29/30, p. 929-931

SCHADER, H. E.: Zur Verwendung von Polamidon in der Morphinentziehung (Use of Polamidon in morphine withdrawal). Medizinische Klinik, 1950, 45:43, p. 1369-1371

SCHAEFER, H.: Ueber die Verwendung von Polamidon in der Kieferheilkunde (Use of Polamidon in stomatology) Zahnärztliche Welt, 1951, 6:5, p. 125-126

SCHAUMANN, O.: Vom Schmerz und seiner Bekämpfung (Pain and its soothing). Klinische Medizin, 1949, 4:15, p. 609-616

-----; LINDNER, E.: Neue synthe-tische Verbindungen der' Polamidonreihe' mit parasympathicolystischer Wir-kung (Synthetic compounds of the Polamidon series with parasympatholytic action). Archiv für experimentelle Pathologie und Pharmakologie, 1951, 214:1, p. 93-102

SCHMITZ-HELFF, K. G.: Erfahrungen mit Polamidon C (Experiences with polamidon C). Die Medizinische, 1953, No. 18, p. 622-624

SCHULDINER, J. A.: Identification of Amidone. Analytical Chemistry, 1949, 21:2, p. 298-300; abstract in Journal of Pharmacy and Pharmacology, 1949, 1:7, p. 488

SCHULTZ, E. M.; ROBB, C. M.; SPRAGUE, J. M.: The reaction of 1-dimethylamino-2-chloropropane with diphenylacetonitrile. The structure of amidone. Journal of the American Chemical Society, 1947, 69:10, p. 2454-2459

SCHWAIGER, M.; BACH, R.: Das neue Analgeticum Polamidon (Hoechst 10820) (The new analgesic, Polamidon (Hoechst 10820) ). Klinische Wochenschrift, 1949, 27:21/22, p. 375-379

SCOTT, C. C.; CHEN, K. K.: The action of 1,1-diphenyl-1-(dimethylaminoisopropyl)-butanone-2, a potent analgesic agent. Journal of Pharmacology and Experimental Therapeutics, 1946, 87:1, p. 63-71; Federation Proceedings, 1946, 5:I, p. 201

-----; -----; KOHLSTAEDT, K. G.; ROBBINS, E. B.; ISRAEL, F.W.: Further observations on the pharmacology of 'Dolophine' (Methadon, Lilly). Federation Proceedings, 1947, 6:II, p. 370; Journal of Pharmacology and Ex-perimental Therapeutics, 1947, 91:2, p. 147-156

-----; ROBBINS, E. B.; CHEN, K. K.: Comparison of somenew analgesic compounds. Science, 1946, 104:2711, p. 587-588; Pharmacologic comparison of the optical isomers of methadon, Journal of Pharmacology and Experimental Therapeutics, 1948, 93:3, p. 282-286

SCOTT, W. W.; LIVINGSTONE, H. N.; JACOBY, J. J.; BROBERG, G. R.: Early clinical experience with dolophine (10820). Current researches in Anesthesia and Analgesia, 1947, 26:1, p. 18-21

SEMLER, H. J.; DAVID, N. A.: Effects of Hydergine (CCK No. 179) - L - isomethadone combinations on respiration and temperature in the rabbit. Journal of Pharmacology and Experimental Therapeutics, 1954, 110:1, p. 46

SHAW, W. H. C.; JEFFERIES, J. P.: The determination of phenadoxone. Journal of Pharmacy and Pharmacology, 1951, 3:11, p. 823-828

SHERROD, T. R.; KAISER, R.; SANTOS-MARTINEZ, J.; PFEIFER, C. C.: Methadon derivatives of pharmacological interest. Federation Proceedings, 1948, 7:I, p. 255

SHIDEMAN, F. E.; JOHNSON, H. T.: Acute vascular tolerance to morphine, isonipecaine (Demerol), and methadon (Amidone) in the dog. Journal of Pharmacology and Experimental Therapeutics, 1948, 92:4, p. 414-420

SLETZINGER, M.: 1-Dimethylamino-2-methyl-3,3-diphenylheximine-4 and preparation thereof. U.S. patent No. 2,538,130. 16 January 1951

-----; TISHLER, M.: Process of preparing 2 2 - diphenyl - 3 - methyl - 4 -dimethylamino butyronitrile. U.S. patent No. 2,574,505, 13 November 1951

-----; -----: Resolution of isoamidone with (L?)-p-nitrobenzyl-glutamic acid. U.S. patent No. 2,625,564, 13 January 1953

SMITH, C. C.; LEHMAN, E.G.; GILFILLAN, J. L.: Antagonistic action of N-allylnormorphine upon analgetic and toxic effects of morphine, methadone derivatives and isonipecaine. Federation Proceedings, 1951, 10:I, p. 335-336

SMOLER, H.: Ein Fall von Polamidon-Missbrauch (A case of Polamidon misuse) Medizinische Klinik, 1950, 45:9, p. 277

SNYDER, F. F.: Action of levo-isomethadone during labor. Federation Proceedings, 1951, 10:I, p. 129-130

SOEHRING, K.; FRAHM, M.: Ueber Morphinnachweis im Harn in Gegenwart von Polamidon (Detection of morphine in urine in presence of Polamidon) Klinische Wochenschrift, 1949, 27:29/30, p. 513-514

-----; LOHR, Jr., H.: Experimentelle Beiträge zum Nachweis vonPolamidon (Hoechst 10820) im Harn (Experimental data on the determination of Polamidon (Hoechst 10820) in the urine). Die Pharmazie, 1950, 5:12, p. 569-571

SPEETER, M. E.: Amidone amines and related derivatives. U.S. patent No. 2,632,762, 24 March 1953

-----; BYRD, W. M.; CHENEY, L. C.; BINKLEY, S. B.: Analgesic carbinols and esters related to amidone. Journal of the American Chemical Society, 1949, 71:1, p. 57-60

STAUGHTON, R. W.: Separation of nitrile intermediates in amidone synthesis. U.S. patent No. 2,540,636, 6 Feb. 1951

STEEL, G. C.; GUNDERSON, E.: Miadone (Physeptone) in obstetrics. Lancet, 1947, 253:6471, p. 370-371

STEELE, C. W.: A comparison of the antidiuretic effect of demerol and of methadon on mercurial diuresis in congestive heart failure; a case report. Journal of the Maine Medical Association, 1949, 40:10, p. 277-281

STEPHAN, W.: Polamidon in der Behandlung des Tetanus (Polamidon in tetanus treatment). Die Medizinische, 1953, No. 31-32, p. 1009-1011

SUNG, C. Y.; WAY, E. L.: The effect of liver on the metabolism of DL-methadone in vitro and in vivo. Journal of Pharmacology and Experimental Therapeutics, 1950, 98:1, p. 72-76

-----; -----: Effect of the liver on the biotransformation of D- andL-methadone. Federation Proceedings, 1952, 11:I, p. 394

-----; -----: Fate of levo-rotaryacetylmethadol, Ibid., 1953, 12:1, p. 370 (No. 1219)

-----; -----: The effect of altered thyroid function on the actions and fate of D,L-methadone. Journal of Pharmacology and Experimental Therapeutics, 1953, 108:1, p. 1-10

-----; -----: The metabolic fate of the optical isomers of methadone, Ibid., 1953, 109:3, p. 244-254

-----; -----: The fate of optical isomers of alpha-acetylmethadol, Ibid., 1954, 110:3, p. 260-270

-----; -----; SCOTT, K. G.: Studies on the relationship of the metabolic fate and hormonal effects of D,L-methadone to the development of drug tolerance. Ibid., 1953, 107:1, p. 12-23

T

TAINTER, M. L.: Estudio comparativo de algunas acciones del demerol y del methadon (Comparative study of some effects of the action of demerol and methadon). Boletín de la Asociación médica de Puerto Rico, 1948, 40:1, p. 1-14

-----; BUCHANAN, O. H.: A comparison of certain actions of demerol and methadone. California Medicine, 1949, 70:1, p. 35-43

TEWES, H.; RUPPRECHT, H.: Polamidon-Missbrauch (Misuse of Polamidon). Muenchener medizinische Wochenschrift, 1950, 92:19/20, p. 785-787

THEYE, R. A.; STOELTING, V. K.; GRAF, J. P.: The use of NU-2206 (3-hydroxy-N-methylmorphinan) for pre-operative medication (abstract). Journal of Pharmacology and Experimental Therapeutics, 1950, 98:1, p. 31

THORP, R. H.: The pharmacology of the optical isomers of amidone (2-dimethylamino-4:4.diphenylheptan-5-one). British Journal of Pharmacology and Chemotherapy, 1949, 4:1, p. 98-104

-----; WALTON, E.; OFNER, P.: Analgesic activity in compounds related to amidone. Nature, 1947, 159:4046, p. 679-680; Optical isomers of amidone, with a note on Isoamidone, Ibid., 1947, 160:4070, p. 605-606

TILS, F. J.: Polamidon in der Chirurgie (Polamidon in surgery). Medizinische Klinik, 1949, 44:42, p. 1346-1347

TROXIL, E. B.: The analgesic action of 1,1-diphenyl-1- (dimethylaminoisopropyl) -butanone-2 in man. Federation Proceedings, 1947, 6:II, p. 378

-----: Clinical evaluation of the analgesic methadon. Journal of the American Medical Association, 1948, 136:14, p. 920-923

U

UCHIYAMA, J.; KIRCHHOF, A. C.; DAVID, N. A.: Spasmolytic action of Dolophine (Amidone). Proceedings of the Society for Experimental Biology and Medicine, 1947, 66:2, p. 417-418 (No. 16110)

V

VAN ARDSELL III, W. C.; DAVID, N. A.: Effects of L-isomethadone and DL-alpha-acetylmethadol on intestinal motility in the rat and rabbit. (No. 1237) Federation Proceedings, 1953, 12:I, p. 375

VERSHININ, N. V.: Phenadon (Methadone) on p. 85 of Pharmakologia, 1952, Medgiz, Moscow, 475 pp.

VOGEL, G.: Beitrag zum Nachweis des Dolantins, Polamidons und Pervitins (Identification of dolantin, polamidon and pervitin). Deutsche Zeitschrift für die gesamte gerichtliche Medizin, 1952, 41:4/5 p. 420-423

VOGEL, K. H.; ISBELL, H.; CHAPMAN, K. W.: Present status of narcotic addiction. Journal of the American Medical Association, 1948, 138:14, p. 1019-1026

W

WALTON, E.: Improvements in or relating to diphenyl ketones of pharmaceutical value and to the preparation thereof. British patent No. 688,481, 11 March 1953

WATSON, R. C.; BOWMAN, M. I.: Microchemical identification of amidone. Journal of the American Pharmaceutical Association (Sc. ed.), 1949, 38:7, p. 369-373

WATTS, D. T.: Inhibition of succinic oxidase system by meperidine, methadon, morphine and codeine. Journal of Pharmacology and Experimental Therapeutics, 1949, 95:2, p. 117-121

-----: Effects of the isomers of methadon and isomethadon on the respiration of brain homogenates. Federation Proceedings, 1949, 8:I, p. 343

-----: Effect of D- and L-methadone on blood glucose and lactate of the dog. Ibid., 1950, 9:I, p. 323-324

-----: The effect of methadone isomers, morphine, and pentobarbital on the blood glucose of dogs. Journal of Pharmacology and Experimental Therapeutics, 1951, 102:4, p. 269-271

WAY, E. L.; SIGNOROTTI, B. T.; MARCH, C. H.: Countercurrent studies on excreta after D,L-methadone administration (abstract). Ibid., 1950, 98:1, p. 34-35; Studies on the urinary, fecal and biliary excretion of D,L-methadone by countercurrent distribution. Ibid., 1951, 101:3, p. 249-258

-----; SUNG, C. Y.: Tissue distribution and excretion of D- and L-methadone. Federation Proceedings, 1952, 11:I, p. 401

-----; -----; FUJIMOTO, J. M.: The effect of adrenalectomy on the development of tolerance to morphine and methadone. Journal of Pharmacology and Experimental Therapeutics, 1954, 110:1, p. 51

-----; -----; McKELWAY, W. P.: The absorption, distribution and excretion of D,L-methadone. Ibid., 1949, 97:2, p. 222-228

-----; -----; -----: Studies on the fate of DL-methadon, Federation Proceedings, 1949, 8:I, p. 344-345

WAYNE, E. J.: Medical relief of pain. British Medical Journal, 1951, 2:4734, p. 787-789

WIKLER, A.: Reactions of chronic decorticated dogs during a cycle of addiction to methadon. Federation Proceedings, 1948, 7:I, p. 265; Reactions of dogs without neocortex during cycles of addiction to morphine and methadone. Archives of Neurology and Psychiatry. 1952, 67:5, p. 672-684

-----; ALTSCHUL, S.: Effects of methadone and morphine on the electro-encephalogram of the dog. Journal of Pharmacology and Experimental Therapeutics, 1950, 98:4, p. 437-446

-----; FRANK, K.: Hind-limb reflexes of chronic spinal dogs during cycles of addiction to morphine and methadone. Ibid., 1948, 94:4, p. 382-400

-----; -----: Tolerance and physical dependence in intact and chronic spinal dogs during addiction to 10820 (4,4-diphenyl-6-dimethylamino-heptanone-3). Federation Proceedings, 1947, 6:II, p. 384

-----; -----; EISENMAN, A. J.: Effects of single doses of 10820 (4-4-diphenyl-6-dimethylamino-heptanone-3) on the nervous system of dogs and cats. Ibid., 1947, 6:II, p. 384

-----; FRASER, H. F.; ISBELL, H.: N-allylnormorphine effects of single doses and precipitation of acute 'abstinence syndromes' during addiction to morphine, methadone or heroin in man (post addicts). Journal of Pharmacology and Experimental Therapeutics, 1953, 109:1, p. 8-20

-----; HOUDE, R. W.: Comparative effects of morphine, methadone, pentothal, nembutal, myanesin and benzinichazole on hind limb reflexes of chronic spinal dogs.

-----; RAYPORT, M.: Lower limb reflexes of a 'chronic spinal' man in cycles of morphine and methadone addiction. American Medical Association Archives of Neurology and Psychiatry, 1954, 71:2, p. 160-170

WILSON, E. H.: Separation of 4-(4'-cyano-4',4'-diphenylbutyl-2') -morpholine from its isomer. U.S. patent No. 2,508,322, 16 May 1950

WILSON, W.: Tetrahydrofurans related to amidone. Journal of the Chemical Society, 1948, p. 1993-1994

-----: Synthetic analgesics and related compounds. Part I. Amidines and 4:5-dihydrogloyxalines (No. 447). Ibid., 1950, p. 2173-2176

WILSON, W. M.; HUNTER, R. B.: 'C.B.11': a new analgesic drug; preliminary communication. British Medical Journal, 1948, 2:4576, p. 553-554

WINTER, C. S.; FLATAKER, L.: Antitussive action of D-isomethadone and D-methadone in dogs. Proceedings of the Society for Experimental Biology and Medicine, 1952, 81:2, p. 463-465, (No. 19912)

WOLFF, P. O.: On pethidine and methadone derivatives. Bulletin of the World Health Organization, 1949, 2:2, p. 193-204

WOODS, L. A.; WYNGAARDEN, J. B.; SEEVERS, M. H.: Addiction potentialities of 1,1-diphenyl-1- (3-dimethylaminopropyl) -butanone-2 hydrochloride (Amidone) in the monkey. Proceedings of the Society for Experimental Biology and Medicine, 1947, 65:1, p. 113-114

WOOLMER, R.: Advances in anaesthesia. Practitioner, 1949, 163:976, p. 320-327

Z

ZOBOLI, P.: Influenza dell'et? e della nutrizione sull'attivité dell'amidone (Influence of age and nutrition on activity of amidone). Acta anaesthesiologica, 1950, 1:6, p. 483-489

Part IV MORPHINAN AND MORPHINE SYNTHESIS

B

BARLTROP, J. A.; NICHOLSON, J. S.: Synthesis in the morphine series. II. Substituted hexohydrodiphenyls and related topics (No. 560). Journal of the Chemical Society, 1951, p. 2524-2529

-----; SAXTON, J. E.: III. Further experiments with β-tetralone, Ibid., 1952. p. 1038-1041

BECKER, J.; BUNDSCHUH, O.: Klinischer Bericht über Dromoran 'Roche' (Analgeticum Ro 1-5431) (Clincial report on Dromoran Roche; analgetic compound Ro 1-5431). Medizinische Klinik, 1952, 47:16, p. 546-548

BELLEAU, B.: A new synthetic approach to the morphine structure. Journal of the American Chemical Society, 1953, 75:5, p. 1159-1163

*BELOHLAV, L.: (Syntheses in the morphine series). Oesterreichische Chemiker-Zeitung. 1951, 25, p. 233-241

BENSON, W. M.; STEFKO, P. L.; RANDALL, L. O.: Comparative pharmacology of D-, DL-, and L-Dromoran and related ether derivatives. Federation Proceedings, 1952, 11:I, p. 322; Comparative pharmacology of levorphan, racemorphan and dextrorphan and related methyl ethers. Journal of Pharmacology and Experimental Therapeutics, 1953, 109:2, p. 189-200

BOENI, A.: Zur Therapie der Arthrosen und Tendinosen (Treatment of joint and tendon diseases). Zeitschrift für Rheumaforschung, 1953, 12:1-2, p. 23-30

BORNSTEIN, M.; YORBURG, L.; JOHNSTON, B.: N-allylnormorphine in treatment of methorphinan (Dromoran) hydrobromide poisoning. Journal of the American Medical Association, 1953, 151:11, p. 908-910

BRECKENRIDGE, C. G.; HOFF, H. E.: Pharmacological analysis of the nervous control of respiration by DL-Dromoran. Archives internationales de pharmacodynamie, 1953, 93:1, p. 1-32

BREINLICH, J.: Nachweis von Dromoran und Cliradon neben Morphin im Urin durch Trübungsreaktion (Detection of dromoran and cliradon in the presence of morphine in urine by turbidity reaction). Arzneimittel-Forschung,1953, 3:4, p. 212-213

BROTMAN, M.; CULLEN, S. C.: Intravenous supplementation during nitrous oxide anesthesia. II. Comparison of morphine, meperidine and a new potent analgesic (NU-2206) with application of multiple covariance analysis. Journal of Pharmacology and Experimental Therapeutics, 1950, 98:1, p. 4 (abstract)

-----; -----; WILKINS, D. S.: Intravenous supplementation during nitrous oxide anesthesia: comparison of demerol, morphine and a new potent analgesic drug (15431). Anesthesiology, 1950, 11:5. p. 527-537

BROWN, A. K.: L-methorphinan as a supplement to nitrous oxide and oxygen anaesthesia. British Medical Journal, 1952, ( 2):4798, p. 1331-1333

C

COOK, J. W.; HEWETT, C. L;. ROBINSON, A. M. (Mrs.) : Stereochemistry of as-octahydrophenanthrene (No. 40). Journal of the Chemical Society, 1949, I, p. 168-177

CRESCENTE, F. J.: Dromoran in general surgery. Journal of the International College of Surgeons, 1951, 16:6, p. 779-782

CURRERI, A. R.; GALE, J. W.; DICKIE, H. A.: Effectiveness of Dromoran (3-hydroxy-N-methyl morphinan) as an analgesic in thoracic surgery. Preliminary report. Journal of Thoracic Surgery, 1950, 20:1, p. 90-96

D

DEBOER, B.; FOSTER, R. H. K.: Respiratory depression in rabbits following administration of NU-22061, morphine sulfate and piperidine analgesics (abstract). Journal of Pharmacology and Experimental Therapeutics, 1950, 98:1. p. 6

DOMINO, E. F.; PELIKAN, E. W.; TRAUT, E. F.: Nalorphine (Nalline) antagonism to racemorphan (Dromoran) intoxication. Journal of the American Medical Association, 1953, 153:1, p. 26-27

E

ERNE, K.: Den firsta morfinsyntesen genoraf?rd (The first synthesis of morphine). Farmaceutisk Revy, 1951, 51, p. 289-294

F

FARBENFABRIKEN BAYER: Verfahren zur Herstellung von 1-benzyl-bz-tetrahydro-isochinolon-(3) (Synthesis of 1-benzyl-bz-tetrahydroisoquinolon. (3) ). German patent No. 830.192, 3 January 1952; Synthesis of 1-benzyl 5,6,7,8-tetrahydroisoquinoline-(3). British patent No. 686.630, 28 January 1953; Verfahren zur Darstellung von 1-benzyl-bz-tetrahydro-isochinolin (Do.). Swiss patent No. 282.091, 16 July 1952; Manufacture of intermediates useful in the syn- thesis of analgesics. British patent No. 684.128, 10 December 1952; Verfahren zur Herstellung von 1-benzyl-l,2,3,4,5,6,7,8-oktohydro-isochinolin. Swiss patent No. 289.377, 1 July 1953

FELLOWS, E. J.; ULLYOT, G. E.: Analgesics. A. Arakkylamines, p. 390-437 in Medicinal Chemistry, Vol. I, vi. John Wiley & Sons Inc., New York, 1951

FIESER, L. F.; HOLMES, H. L.: The synthesis of phenanthrene and hydrophenanthrene derivatives. V. The addition of dienes to cyclic αβ-unsaturated esters. Journal of the American Chemical Society, 1936, 58:11, p. 2319-2322; VIII. Substances related to degradation products of morphine. Ibid., 1938, 60:10, p. 2548-2555

FISCHER, A. L.; LONG, J. P.: The absorption and excretion of Dromoran. Journal of Pharmacology and Experimental Therapeutics, 1953, 107:2, p. 241-249

FRASER, H. F.; FLANARY, H. G.; HOUDE, R. W.; ISBELL, H.: Addiction liabilities of some drugs in the morphine series. Federation Proceedings, 1950, 9:I, p. 273

-----; ISBELL, H.: Addiction liabilities of morphinan, 6-methyldihydromor-phine and dihydrocodeinone. Journal of Pharmacology and Experimental Therapeutics, 1950, 100:2, p. 128-135

FROMHERZ, K.: Pharmacological effects of 3-hydroxy-N-methylmorphinan. Archives internationales de pharmacodynamie, 1951, 85:3-4, p. 387-398

-----; PELLMONT, B.: Morphinantagonisten (Morphine antagonis). Experienta, 1952, 8:10, p. 394-395

G

GATES, M.; NEWHALL, W. F.: The synthesis of ring systems related to Morphine. I. 9,10-dioxo-13-cyanomethyl-5,8,9,10,13,14 - hexahydrophenanthrene. Journal of the American Chemical Society, 1948, 70:6, p. 2261-2263

-----; WOODWARD, R. B.; NEWHALL, W. F.; KUENZLI, R. M.: IV. N-methylisomorphinane. Ibid., 1950, 72, p. 1141-1146

-----; NEWHALL, W. F.: II. The carbon-nitrogen ring system. Experientia, 1949, 5:7, p. 285-286

-----; TSCHUDI, G.: The synthesis of racemic β- Δ -6-dihydrodesoxycodeine methyl ether (a letter). Journal of the American Chemical Society, 1950, 72:10, p. 4839-4840; The synthesis of morphine (a letter). Ibid., 1952, 74:4, p. 1109-1110

BULLETIN ON NARCOTICS • SEPTEMBER-DECEMBER 1954 85GERCHOW, J.: Prognostiche Erörterungen zur Frage Dromoran und Sucht (Prognostic aspects of Dromoran and addiction). Muenchener medizinische Wochenschrift, 1952, 94:52, p. 2618-2619

GHOSH, R.; ROBINSON, R. (Sir): Synthesis of substances possibly obtainable as degradation products of thebaine (No. 140). Journal of the Chemical Society, 1944 I, p. 506-510

GINSBURG, D.: The synthesis of morphan (2-azabicyclo [3-3-1]nonane). Journal of Organic Chemistry, 1950, 15:5, p. 1003-1005

-----; PAPPO, R.: Preliminary syntheses in the morphine series. II. The synthesis of 2-Arylcyclohex-2-enones (No. 109). Journal of the Chemical Society, 1951, p. 516-519

GLAZEBROOK, A. J.: Actions and uses of methorphinan. British Medical Journal, 1952 (2):4798, p. 1328-1330

GREWE, R.: Synthesen in der Phenanthren-Reihe. I. (No. 75) (Syntheses in the phenanthrene series. I). Berichte der deutschen chemischen Gesellschaft, 1939 B, 72:2, p. 426-432; Do. II (No. 133). Ibid., 1939 B, 72:4, p. 785-790; Do. III (217). Ibid., 1939 B, 72:6, p. 1314-1317; IV. Phenanthrenderivaten mit angulater Seitenkette (IV. Phenanthren derivatives with angular side-chain). (No. 169). Ibid., 1943 B, 76:10, p. 1072-1076; V. Anwendung der Reformatskischen Reaktion (Use of the Reformatsky reaction). (No. 170). Ibid., 1943 B, 76: 10, p. 1076-1083

-----: Das Problem der Morphin-Synthese (The problem of the morphine synthesis). Die Naturwissenschaften, 1946, 33:11, p. 333-336

-----: Synthetische Arzneimittel mit Morphin-Wirking (Synthetic medical drugs with morphine-like action). Angewandte Chemie, 1947, 59:7-8, p. 194-199

-----: Verfahren zur Herstellung von n-methyl-morphinan, seinen Oxy- und Alkoxyderivaten und deren Salzen. German patent. No. 842.344, 8 May 1952

-----; MONDON, A.: Synthesen in der Phenanthren-Reihe. VI. Synthese des Morphinans (Syntheses in the phenanthrene series. VI. Synthesis of morphinan). Chemische Berichte, 1948, 81:4, p. 279-286

-----; -----; NOLTE, E.: Die Totalsynthese des Tetrahydro-desocodeins (Total synthesis of tetrahydro-desocodeine). J. L. Annalen der Chemic, 1949, 564:3, p. 161-198

-----; POHLMANN, H.; SCHNOOR, M.: Ein neuer Weg zum Morphinan (A new synthesis of morphinan). Chemische Berichte, 1951, 84:5-6, p. 527-531

GRIESSER, G.; HENFTLING, T.: Erfahrungen mit Dromoran Roche in der Behandlung chirurgischer Schmerzzustände (Experience with Dromoran in treatment of post-operative pain). Deutsche medizinische Wochenschrift, 1953, 78:18, p. 672-674

GROSS, E.G.; BROTMAN, M., et al.: New potent analgesic agent (NU-2206). Federation Proceedings, 1949, 8:I, p. 297

-----; FEATHERSTONE, R. M.: Studies on some smooth muscle effects of 3-hydroxy-N-methylmorphinan hydrobromide (NU-2206). Federation Proceedings, 1950, 9:I, p. 279

GULLAND, J. M.; ROBINSON, R.: The morphine group. I. A discussion of the constitutional problem (No. 112). Journal of the Chemical Society, 1923, 123, p. 980-998; II. Thebainone, thebainol and dihydrothebainone (No. 113). Ibid., p. 998-1011

H

HAGEMEYER, G.: Zur Behandlung schwerer, akuter und chronischer Schmerzzustände in der Chirurgie (Treatment of severe, acute and chronic pain in surgery). Die medizinische Welt, 1951, 20:41. p. 1286-1288

HAMILTON, W. K.; CULLEN, S.C.: Effect of levallorphan tartrate upon opiate-induced respiratory depression. Anesthesiology, 1953, 14:6, p. 550-554

HARNASCH, H.: Zur Frage der Schmerzbekämpfung bei Krebskranken mit Dromoran 'Roche' (Dromoran analgesia in cancer). Muenchener medizinische Wochenschrift, 1952, 94:4, p. 164-168

HENECKA, H.: Neue Synthesen in der Morphinan-Reihe (New syntheses in the morphinan series). J. L. Annalen der Chemie, 1953, 583:2, p. 110-128

HOFFMANN-LA ROCHE & Co., A. G.: Verfahren zur Darstellung einer Hydrophenanthrenverbindung (Synthesis of a hydrophenanthren compound). Swiss patent No. 252.755, 16 October 1948; Verfahren zur Herstellung eines Piperidooctahydrophenanthren - Abkömmlings (Synthesis of a piperido-octahydrophenanthren derivate). Swiss patent No. 254.106, 1 December 1948; (3-hydroxy-N-methylmorphinan) and its salts. German patent No. 802.571, 15 February 1951

HORNING, E. C.; HORNING, M. G.; PLATT, E. J.: Morphine studies. 2-(2', 3'-Dimethoxyphenyl)- 2 -(-ethoxyethyl)-cyclohexanone. Journal of the American Chemical Society, 1948, 70:6, p. 2072-2075

-----; SCHOCK Jr., R. U.: Morphine studies. 2-keto-7-methoxy-2, 3-dihydrobenzofuran derivatives. Ibid., 1948, 70:9, p. 2941-2944; Morphine studies. Tetralin analogs. Ibid., p. 2945-2949; Morphine studies. The synthesis of a tetralin-piperidine fused-ring system. Ibid., 1949, 71:4, p. 1359-1362

HOUDE, R. W.; WALLENSTEIN, S. L.: Comparisons of oral vs. parenteral effectiveness of some analgetics on patients with pain due to cancer. (No. 1208) Federation Proceedings, 1954, 13:I, p. 367-368

I

ISBELL, H.: Addiction liabilities of D- and L - 3 - hydroxy - N - methylmorphinan. Preliminary report to the WHO Expert Advisory panel on drugs liable to produce addiction. WHO/APD/32, 18 December 1951.

-----; FRASER, H. F.: Actions and addiction liabilities of Dromoran derivatives in man. Journal of Pharmacology and Experimental Therapeutics, 1953, 107:4. p. 524-530

J

JAGGARD, R. S.; ZAGER, L. L.; WILKINS, D. S.: Clinical evaluation of analgesic drugs. A comparison of NU-2206 and morphine sulphate administered to postoperative patients. A.M.A. Archives of Surgery, 1950, 61:6, p. 1073-1082

JUNKERMAN, C. L.; HEEN, R. C.; POHLE, H. W.: Clinical experience with a new analgesic agent (NU-2206). Proceedings of the Central Society for Clinical Research, 1949, 22, p. 43; abstract in Journal of Laboratory and Clinical Medicine, 1949, 34:11, p. 1615; Clinical experience with a new analgesic agent (Dromoran hydrobromide). Journal-Lancet, 1951, 71:7, p. 263-265

K

KAYSER, F.: Konstitution und Synthese des Morphins (Constitution and synthesis of morphine). I. Chemiker Zeitung, 1953, 77:19, p. 645-648; II. Ibid., 1954, 78:2, p. 37-41

KEUTMANN, E.; FOLDES, F. F.: The analgesic effect of Dromoran hydrobromide (3-hydroxy-N-methyl morphinan hydrobromide) in postoperative pain. New England Journal of Medicine, 1951, 244:8, p. 286-288

KITASATO, Z.; ROBINSON, R.: Preliminary synthetic experiments in the morphine group. III Some derivatives of papaveroline and Laudanosoline (No. 102). Journal of the Chemical Society, 1932 (I), p. 785-788; also in Chemisches Zentralblatt, 1932 (I), p. 3180

KOELSCH, C. F.: Experiments on the synthesis of compounds related to morphine. I. The internal Michael reaction. Journal of the American Chemical Society, 1945, 67:4, p. 569-574; Use of 2-phenylcyclohexanone in experiments on the synthesis of morphine. Ibid., 1951, 73:6, p. 2951-2952

L

LEE, J.: Analgesics B. Partial structures related to morphine, in Medicinal Chemistry, Vol. I, vi, p. 438-446 (John Wiley & Sons Inc., New York, 1951)

LEE, R. E.; HASEGAWA, A. K.: Human analgesic testing of experimental drugs: Nisentil (NU-1196) and NU-2206. (abstract). Journal of Pharmacology and Experimental Therapeutics, 1950, 98:1, p. 20-21

-----; PFEIFFER, C. C.: Influence of analgesics Dramaran, Nisentil and morphine on pain thresholds in man. Journal of Applied Physiology, 1951, 4:3, p. 193-198

M

MAY, E. L.; MURPHY, J. G.: Structures related to morphine. Synthesis of an analog of N-methylmorphinan. American Chemical Society, 126th meeting. 12-17 September 1954. Abstracts of papers, p. 18N-19N

McCORMICK, W. C.; KNIKER, W. T.: Effects of increasing doses of morphine, Dromoran and sodium amytal on rat tissues in vivo and in vitro. Texas Reports on Biology and Medicine, 1953, 11:2, p. 274-282

N

NEWMAN, M. S.; MAGERLEIN, B. J.: The synthesis of hydroaromatic compounds containing angular groups. III. 9,4a(2) - iminoethanohydrophenanthrene series. Journal of the American Chemical Society, 1947, 69:4, p. 942-944

-----; MOSBY, W. L.: Attempted synthesis of a morphine degradation product. Ibid., 1951, 73:8, p. 3738-3740

P

PELLMONT, B.: The influence of different drugs on the analgesic activity of Levorphan. Journal of Pharmacology and Experimental Therapeutics, 1954, 110:1, p. 42

PERLMAN, D.; DAVIDSON, D.; BOGERT, M. T.: The synthesis of phenanthrenes from hydroxyl derivatives of beta-phenylethyl-cyclohexanes and the nature of the by-product . Journal of Organic Chemistry, 1936, 1:3, p. 288-299

PITRE, D.: Sintesi della morfina (Morphine synthesis). Il Farmaco ( Ed. Sc.), 1952, 7:4 p. 456-467

PRELOG, V.: Racemisierungsversuche mit (?) -3-Oxy-N-methylmorphinan (Experiments on racemisation with (?) -3-Oxy-N-methylmorphinan. Hoffman-La Roche booklet, 26 February 1953

R

RANDALL, L. O.; LEHMANN, G.: Analgesic action of 3-hydroxy-N-methylmorphinan hydrobromide (NU-2206). Federation Proceedings, 1950, 9:I, p. 217

RECHENBERG, von, H. K.; ZEERLEDER, R.: Klinische Erfahrungen mit Dromoran [ ( - ) -3-oxy-N-methyl-morphinan-tartrat] einem neuen synthetischen Analgeticum (Clinical experiences with Dromoran [ ( - ) -3-oxy-N-methyl-morphinan tartrate] a new synthetic analgesic). Schweizerische medizinische Wochenschrift, 1951, 81:44, p. 1086-1089

REICHSTEIN, T.: Gutachtliche Aeusserung (Experts' opinion) (Dextrorphan). Hoffman-La Roche's booklet, 28 March 1953

ROBINSON, R.; SUGASAWA, S.: Preliminary synthetical experiments in the morphine group. I. (No. 438) Journal of the Chemical Society, 1931, (II), p 3163-3172; II. Some derivatives of diphenyl ether (No. 439). Ibid., p. 3173-3176; IV. A dihydro-derivative of laudanosoline hydrochloride and its constitution. Ibid., 1932 (I), p. 789-805; also in Chemisches Zentralblatt, 1932, I, p. 3180-3183; V. Completion of the synthesis of a laudanosoline dimethyl ether related to sinomenine. (No. 771) Journal of the Chemical Society. 1933 (I), p. 280-281

S

SCHLITTER, R.; MUELLER, J.: Eine neue Modifikation der Isochinolinsynthese nach Pomeranz-Fritsch (No. 128) (A new modification of the synthesis of isoquinolin after Pomeranz-Fritsch). Helvetica chimica acta, 1948. 31:3. p. 914-924

SCHNIDER, O.; GRUESSNER, A.: Synthese von Oxy-morphinanen (Oxy-morphinan synthesis). Helvetica chimica acta, 1949, 32:3, p. 821-828 (British patent 620.258); III. Optisch aktive 3-Oxy-morphinane (Hydroxy-morphinan. III. Optically active 3-hydroxy morphinan). Ibid., 1951, 34:7, p. 2211-2217

-----; HELLERBACH, J.: Synthese von Morphinanen. II (British patent Hoffman-La Roche No. 633,266), Ibid., 1950, 33:6, p. 1437-1438; Oxy-morphinan. IV Synthese von Benzyl-octahydro-isochinolinen (Hydroxymorphinan. Synthesis of benzyloctahydroisoquinolines). Ibid., 1951, 34:7, p. 2218-2222

SCHOEPF, F. C.; PERREY, H.; JAECKH. I.: Synthetische Versuche in der Benzyl-isochinolin-Reihe (Attempts at synthesis in the benzyl-isoquinolin series). Annalen der Chemie, 1932, 497, p. 47-58; II. Die Darstellung des N-Methyl-1-(3'oxy-4'-methoxyl-benzyl) -6-oxy-tetrahydro-isochinolins und des Laudanosolin-4'-methyläthers (Synthesis of N-Methyl-1- etc. and of Laudanosolin-4'-methyl-ether). Ibid., 1932, 497, p. 59-68

-----; THIERFELDER, K.: PERREY, H.; JAECKH, I.: II. Die dehydrierung des Laudanosolins und des Laudanosolin-3',4'-dimethyläthers. Ibid., 1932, 497, p. 22-46 (Dehydrating of Laudanosolin and of Laudonosolin-3',4'-dimethylether) III. Laudanosolin-3'-7-dimethyläther aus Laudanesolin. Ibid., 1939, 537, p. 143-156 ische, 1953. 10. p. 323-324

SENNE, W.: Therapeutische Erfahrungen mit dem neuen synthetischen Analgetikum Dromoran Roche (Therapeutic experiences with the new synthetic analgesic Dromoran Roche). Die Medizinische, 1953. 10, p. 323-324

SIEGEL, B. M.; BLOCH, D. P.; PITESKY, I.; LAST, J. H.: Comparative study of morphine and dromoran as antidiuretic agents in the dog. Proceedings of the Society for Experimental Biology and Medicine, 1950, 74:4, p. 809-812 (18056)

SLOMKA, M. B.; GROSS, E. G.: An evaluation of the analgetic activity of the dromoran isomers. Proceedings of the Society for Experimental Biology and Medicine, 1952, 81:2, p. 548-550 (19936)

SMITH, R. M.: Clinical experience with dromoran hydrobromide (NU 2206) for the relief of chronic pain. Southern Medicine and Surgery, 1950, 112:8, p. 251-252

SOFFER, M.D.; CAVAGNOL, J. C.; GELLERSON, H. E.: Syntheses in the direction of morphine. I. 7-methoxy- and 7,8-dimethoxy-2-tetralone. Journal of the American Chemical Society, Washington, D.C., 1949, 71:11, p. 3857

STERN, E. S.: Synthetic approaches to the morphine structure. Quarterly Reviews (London), 1951, 5:4, p. 405-419

STOELTING, V. K.; THEYE, R. A.; GRAF, J.P.: The use of dromoran hydrobromide (3-hydroxy-N-methyl morphinan hydrobromide) for preoperative medication. Anesthesiology, 1951, 12:2, p. 225-229

STORK, G.; CONROY, H.: Elaboration of the 1-substituted 7,8-dimethoxy-2-tetralones toward the 13-alkyl hydrophenanthrene system of morphine. Journal of the American Chemical Society, 1951, 73:10, p. 47-51

SUTER, C. M. (Editor in Chief): Medicinal Chemistry, 1951, Vol. 1:vi, 473 p. John Wiley & Sons, Inc.: New York. ( Analgesics: A. Aralkylamines by FELLOWS, E. J.; ULLYOT, G. E., p. 390-437; B. Partial structures related to morphine by LEE, J., p. 438-446

T

TIDRICK, R. T.; ZAGER, L. L.; EASTWOOD, D. W.; WILKINS, D. S.; JAGGARD, R. S.: Control comparison of NU-2206 (3-hydroxy-N-methyl-morphinan hydrobromide) with morphine sulphate for relief of post-operative pain. Proceedings of the Central Society for Chemical Research, 1949, 22, p. 85-86

Control comparison of NU-2206 (3-hydroxy-N-methyl-morphinan hydrobromide) with morphine sulphate for relief of post-operative pain. Journal of Laboratory and Clinical Medicine, 1949, 34:11,p. 1758-1759

V

VIDIC, E.: Nachweis und quantitative Bestimmung des Dromoran sowie seine Unterscheidung von anderen stark wirkenden Analgetica in Biologischem Material (Detection and quantitative determination of dromoran as well as its differentiation from other analgesics with powerful effect in biological material).

----; BREINLICH, J.: Zum mikro-chemischen Nachweis von Cliradon und Dromoran im Urin (Microchemical determination of cliradon and dromoran in urine). Arzneimittel-Forschung,1953, 3: 9, p. 490-491

W

WEGERHOFF, L.: Erfahrungen mit einem neuen Analgeticum; Dromoran Arzneimittel-Forschung,1953, 3: B, p. 423-435

Part V DITHIENYLBUTENYLAMINES

B

BILLINGHURST, J. W.: Part 111. 3-tertiary-amino-l-aryl-l-(2-pyridyl)- propan-l-ols and -prop-l-enes. Ibid., 1950, p. 1039-1045 (No. 212)

D

DUFFIN, W. M.; GREEN, A. F.: Dithienylbutylamines as analgesics. Nature,1951, 167:4239, p. 153-154

E

EDDY, N. B.; LEIMBACH, D.: Synthetic analgesics. 11. Dithienylbutenyl- and Di- thienylbutylamines. Journal of Pharmacology and Experimental Therapeutics, 1953, 107:3, p. 385-393

F

FLINTAN, P.; KEELE, C. A.: Clinical trial of some analgesic dithienylalkenylamines. Journal of Pharmacology and Experimental Therapeutics, 1954, 110:1, p. 18 (abstract)

G

GREEN, A. F.: A new series of analgesics (a letter), Ibid., 1950, 165:4186, p. 122

GREEN, A. F.: Analgesic and other properties of 3:3-dithienylalkenylamines. British Journal of Pharmacology and Chemotherapy, 1953, 8:1, p. 2-9

I

ISBELL, H.; FRASER, H. F.: Actions and addiction liability of the dithienyl- butenylamines in man. Journal of Pharmacology and Experimental Therapeutics, 1953, 109:4, p. 417-421

L

LOEFGREN, N.; TEGNER, C..- Studies on analgesics. 1. Synthesis of ethyl 4- N-morpholinyl) - 1,1-di-(a-thienyl)-buty- rate and its pharmacological properties. Acta Chemica Scandinavica, 1952, 6:7, p. 1020-1023

W

WIKLER, A.: Addiction-liability of dithienylbutylamines. Federation Proceedings, 1953, 12.-I, p. 333 (No. 1097)