NPS substances in this category are structurally diverse and do not fit into the categories mentioned above for example, 1,3-dimethylamylamine (DMAA). Substances from this group have diverse pharmacological effects, such as:

Classic hallucinogens (psychedelics) mediate specific serotonin-receptor activities and produce hallucinations. Substances in these group mimic the effects of traditional drugs such as 2C-B, LSD and DMT but may also possess residual stimulant activity.

Opioids belong to a chemically diverse group of central nervous system depressants. They bear structural features that allow binding to specific opioid receptors, resulting in morphine-like effects e.g. analgesia.

Sedatives / Hypnotics are central nervous system depressants. They mimic the effects of substances under international control such as the benzodiazepines diazepam and alprazolam.

Stimulants mediate the actions of dopamine, norepinephrine and/or serotonin, mimicking the effects of traditional drugs such as cocaine, amphetamine, methamphetamine, and ecstasy.