A. General Works
B. Pethidine and Related Compounds
C. Methadone and related compounds
D. Morphinan and morphine synthesis
E. Dithienylbutenylamines and miscellaneous synthetics


Pages: 41 to 47
Creation Date: 1956/01/01



The Bulletin on Narcotics first published a bibliography on synthetic narcotic drugs in Volume III, No. 2, followed by another more comprehensive one in Volume VI, No. 2, and Volume VI, No. 3-4. It is felt, however, that the abundance of new material makes it worthwhile to publish at this time an additional bibliography on the same subject.

This bibliography has no claim to be complete, and information regarding books or articles not included in it would be gratefully received by the Division of Narcotic Drugs, Department of Economic and Social Affairs, European Office of the United Nations, Geneva, Switzerland. As before, this bibliography has been arranged by subject in the following way:

A. General works

B. Pethidine and related compounds

C. Methadone and related compounds

D. Morphinan and morphine synthesis

E. Dithienylbutenylamines and miscellaneous synthetics Under each heading, publications are arranged alphabetically by author. Owing to the nature of the sources available to the secretariat for preparing this bibliography, several titles are given in translation only. They are preceded by an asterisk.

A. General Works


ANONYMUS: Expert Committee on Drugs Liable to Produce Addiction. Fifth report. World Health Organization Technical Report Series, 1955, 95, p 1-16.


BADGER, G. M.; COOK, J. W.; DONALD, G. M. S.; GRAHAM, J. D. P.; WALKER, T.: Synthetic Analgesics . Nature, 1948, 162: 4105, p. 21.

BECKETT, A. H.; CASY, A. F.: Stereochemistry of certain analgesics. Nature, 1954, 173, p. 1231-1232.

-; -: Synthetic analgesics: stereochemical considerations. Journal of Pharmacy and Pharmacology, 1954, 6, p. 986-1001.

BERGEL, F.; MORRISON, A. L.: Synthetic Analgesics, Quarterly Review, 1948, 2: 4, p. 319-382.

BRAENDEN, O. J.; WOLFF, P. O.: Synthetic substances with morphine-like effect. Bulletin of the World Health Organization, 1954, 7: 10, p. 1-25.


DONATELLI, L.: II dolore ed i farmaci antidolorifici (Pain and analgesic drugs). Rassegna Internazionale di Clinica e Terapia, 1955, 35: 1, p. 11-19; ibid. 35: 2, p. 50-59; ibid. 35: 4, p. 128-134.


EISENBERG, W. V.: Microscopic tests for alkaloids and synthetics. Journal of the Association of Official Agricultural Chemists, 1955, 38, p. 653-655.


GADDUM, J. H.: Pharmacology, 4th edition, XVIII + 562 pp. illus. Oxford University Press, New York, 11. (1953).

GEIST, G.: (Addiction dangers of synthetic analgesics). Pharmazeutische Zeitung ver. Apotheker Zeitung, 1953, 89, p. 831-834.


HAAS, H.: (Comparison of analgesics). N. Sch. Archiv für experimentelle Pathologie und Pharmakologie, 1955, 225, p. 442-452.

HILDEBRANDT, F.; MATTHAY, E.: Die Wirkung der starken Analgetica Polamidon, Polamidon C (Polamivet) und Dromoran auf die Darmmotilität. (The effect of powerful analgesics, such as polamidone and polamidone C (polamivet) and dromoran on intestinal motility). N. Sch. Archiv für experimentelle Pathologie und Pharmakologie, 1954, 221: 5, p. 399-403.


KUDAKOVA, N. A.: (Use of non-exchange resins in the determination of pharmaceuticals). Aptechnoe Delo, 1955, 4: 4, p. 34-37.


LESPAGNOL, A.: Les analgésiques centraux de synthèse. Les succédanés synthétiques de l’opium. Actualités pharmacologiques, 1949, 1, p. 145-161; ibid., 1951, 3, p. 27-47.

LEWENSTEIN, Mozels J.: The preparation of compounds having a narcotic effect. British Patent, No. 713675 18 August 1954.

LEWIS, J.R.: A study of the development of tolerance to the actions of 1-Methyl -4-(3-hydroxyphenyl)-4-piperidyl ethyl ketone hydrochloride in dogs. Journal of Pharmacology and Experimental Therapeutics, 1949, 96: 4, p. 410-415.

-; The development of tolerance in rats to some new synthetic analgesics. Journal of Pharmacology and Experimental Therapeutics, 1949, 96: 1, p. 31-37.

LUNDY, J. S.: Development of Analgesia after a century of anesthesia. Journal of the American Medical Association, 1955, 157: 16, p. 1399-1403.


MACDONALD A. D.: Le soulagement de la douleur. Annales Pharmaceutiques Françaises, 1954, 12: 9-10, p. 663-671.

MAROLDA, C. I.: Analgésicos centrales sintéticos (Synthetic central analgesics). Semana Médica, 1955, 106: 11, p. 292-297.

MARTINETTO, G.: (Synthetic analgesics for pre-anesthetic treatment). Minerva Anestesiologica, 1955, 21, p. 86-91.

MERGER, R.; LEVY, J.; BOURRICHON: Effets sur le travail de l'accouchement de l'association analgésique nembutal-dolosal-trilene. Bulletin de la fédération des sociétés de gynécologie et d' obstétrique de langue française, 1953, 5: 3, p. 304-306.

-; MELCHIOR , J.: L'Analgésie obstéricale par l'association médicamenteuse: nembutal-dolosal-trilene. Bulletin de la fédération des sociétés de gynécologie et d'obstétrique de langue française, 1953, 5: 5. p. 301-304.

MILLER, J. W.; ELLIOTT, H. W.: Rat tissue levels of carbon-14 labeled analgetics as related to pharmacological activity. Journal of Pharmacology and Experimental Therapeutics, 1955, 113: 3, p. 283-291.

MORRISON, A. L.; RINDERKNECHT, H.: Synthetic Analgesics. Jubilee Volume Emil Barell (Hoffmann-La Roche), 1946, p. 253-263.


ORTH, O. S.: Newer drugs for general anesthesia. Postgraduate Medicine, 1954, 15: 5, p. 393-398.


PÓRSZÁSZ, J.; KNOLL, J.; KOMLÓS, E.: Wirkung der Parasympathomimetika auf die Analgesie (Effect of parasympathetic substances on analgesia). Acta Physiologica Academiae Scientiarum Hungariae, 1951, 2: 3-4, p. 469-477.


SCHAUMANN, O.: Die Wirkungsspezifität der morphinähnlichen Analgetica (Specificity of action of morphine-like analgetics). Arzneimittel-Forschung, 1954, 4: 3a (special), p. 115-116.

-; (150 years of morphine and 15 years of synthetic morphine-like analgetics). Angewandte Chemie, 1954, 66, p. 765-768.

SOEHRING. K.: Neuere synthetische Arzneimittel mit zentralanalgetischer Wirkung (New synthetic drugs with central analgesic action). Medizinische Klinik, 1950, 45: 27, p. 817-822.


THORP, R. H.: The assessment of analgesic activity in new synthetic drugs. British Journal


TSAO, Yer Fang: The preparation of analogs of demerol, amidone, and isoamidone and the reactions of certain nitriles with Grignard reagents. University Microfilms (Ann Arbor, Mich.). Pub. No. 5752, 128 pp.; Dissertations abstracts, 1953, 13: 5, p. 2061.

TSUTOMU, E.: Biochemistry of the poisoning with narcotics. Shizen (Nature), 1954, 9: 5, p. 30-39.


VIDIC, E.; BREINLICH, J.: Zum mikrochemischen Nachweis von Cliradon und Dromoran im Urin (Microchemical determination of cliradon and dromoran in urine). Arzneimittel-Forschung, 1953, 3: 9, p. 490-491.


WALSCH, E. O. F.: Habit-forming drugs and cell metabolism. Pharmaceutical Journal, 1954, 119, p. 483-484.

B. Pethidine and Related Compounds


ANDERSEN, H. C.;JEPSEN, O.; KRISTIANSEN, F.: Nystagmus induced by pethidine. Acta Oto-Laryngologica, Supplementum, 1953, 109, p. 9-14.

AREZIO, G.; PERUZZO, L.; VERGA, G.: Azione dei farmaci componenti il cocktail vegetativolitico (cloropromazina, prometazina, mefedina), somministrati isolamente, sul surrene di ratto (Action of the lytic cocktail drugs [chlorpromazine, promethazine, mephedine] administered separately, on the adrenal glands of rats). Acta Anaesthesiologica, 1955, 6: 1, p. 1-10.

ARGENT, D. E.; DINNICK, O. P.: Pethidine phlebitis. British Journal of Anaesthesia, 1954, 26: 4, p. 260-263.

AVISON, A. W. D.; MORRISON, A. L.: Synthetic Analgesics. VI. The synthesis of ketobemidone. Journal of the Chemical Society, 1950, p. 1469-1471. VII. Metadine and related 3-phenyl piperidine derivatives (4304) p. 1471-1474, No. 305. VIII. Further attempts to prepare 3-phenylpiperidine derivatives, p. 1474-1477.


BACHRACH, E. H.; GODHOLM, A. N.; BETCHER, A. M.: Clinical observations on the use of alphaprodine (nisentil) for postoperative analgesia. Surgery, 1955, 37: 3, p. 440-445.

BADGER, G. M; COOK, J. W.; WALKER, T.: Synthesis of Piperidine derivatives. II. Aryldecahydroquinolines. Journal of the Chemical Society, 1948, II, p. 2011-2017.

_____; COOK, J. W.; CROSBIE, G. W.: The chloromethylation of naphtalene and of Tebalin. Journal of the Chemical Society, 1947, II. p. 1432-1434.

BALIAH, V.; GOPALAKRISHNAN, V.: Synthesis of some 4-piperidone derivatives. Journal of the Indian Chemical Society, 1954, 31, p. 250-252.

BARR, W.; COOK, J. W.: Synthesis of Piperidine derivatives, part I. Journal of the Chemical Society, 1945, I. p. 438-441.

BATTERMANN, R. C.: Clinical effectiveness and safety of a new synthetic analgesic drug, Demerol. Archives of International Medicine, 1943, 71: 3, p. 345-356.

-;Demerol; a new synthetic analgesic: its indications as a substitute for morphine. Connecticut Medical Journal, 1944, 8: 1, p. 13-17.

-; MULHOLLAND, J. H.: Demerol; a substitute for morphine in the treatment of postoperative pain. Archives of Surgery, 1943, 46: 3, p. 404-409.

BAZANOVA, S. V.; KLEMENT’EV, F. V.; KISELEVA, K. I.: Sravuitel'noe deistvie atropina, lidola i tifena pri lechenii bol'nykh s of Pharmacology and Chemotherapy, 1946, 1: 2, p. 113-126 diskineticheskimi zaporami (Comparative effects of atropin, lidol and thiphen in Therapy of diskinetic constipation). Sovietskaia Meditsina, 1954, 18: 4, p. 29-31.

BAZANOVA, V. B. S. V.: Promedol-boleuto-liaiushchee sredstbo pr lichenii vnutrennukh zabobevanuy (Promedol-analgesic in the treatment of internal disease). Sovietskaia Meditsina, 1954, 18: 10, p. 39-40.

BELINKOFF, S.: Preoperative sedation with nisentil. Current researches in Anesthesia and Analgesia, 1955, 34: 2, p. 116-118.

BENTHIN, W.: Schmerzlinderung in der Geburt durch Dolantin (Dolantin in delivery). Deutsche Medizinische Wochenschrift, 1940 , 66, p. 760-762.

BERGEL, F.; MORRISON, A. L.; RINDERKNECHT, H.: No. 69 Synthetic Analgesics. II. A new synthesis of Pethidine and similar compounds, p. 265-267; No. 70 III. The action of hydrogen halides on ethers of α α - bis- (B'hydroxyethyl) phenylacetonitrile, p. 267-269. No. 70 IV. Synthesis of 3-substituted piperidino and pyrrolidines, p. 269-272. Journal of the Chemical Society, 1944.

BIEL, J.H.; SPRENGELER, E. P.; LEISER, H. A.; HORNER, J.; DRUKKER, A.; & FRIEDMAN, H. L.: Antispasmodics. II. Derivatives of N-substituted-3-piperidols. Journal of the American Chemical Society, 1955, 77: 8, p. 2250-2256.

BLICKE, F. F.; TSAO, E. P.: Preparation of 1-methyl-4-phenyl-4-(aminomethyl)- and 1-methyl-4-phenyl-4- (methylaminomethyl)-piperidine. Journal of the American Chemical Society, 1953, 75, p. 5417-5418.

BRENDER, H.: Zur Pharmakologie der Phenyl-(1-piperidino) - essigsäure-s - diethylaminoethyl-esters (Pharmacology of 2-(diethylamino-) ethyl phenyl piperidino-acetate). Arzneimittel-For-schung, 1954, 4: 2, p. 67-70.

VON BRUECKE, S.: Ueber Dolantin Abusus und einen Fall von Dolantin delirium (Abuse of dolantin; a case of delirium caused by that drug). Wiener klinische Wochenschrift, 1940, 53, p. 854-856.

BURNS, J. J.; BERGER, B. L.; LIEF, P. A.; WOLLACK, A.; etc.; The physiological disposition and fate of meperidine (demerol) in man and a method for its estimation in plasma. Journal of pharmacology and experimental therapeutics, 1955, 114: 3, p. 289-298.


CALZOLARI, G.: Analgesia profonda ed anestesia locale nella chirurgia della tiroide (Deep analgesia and local anesthesia in thyroid surgery). Minerva anestesiologica, 1955, 21: 6, p. 141-143.

CLARK, B. B.: The effect of syntropan, demerol, and trasentine on gastric secretion. Federation Proceedings, 1947, 6: 1, Part I, p. 48.

CLIMENKO, D. R.: Demerol: A pharmacologically active substance with atropine-like and morphine-like properties. Federation Proceedings, 1942, 1, p. 15.

COLLADOS STORNI, M. P.: Anestesia con petidina endovenosa para amigdalectomias; comunication prevista (Pethidine intravenous anesthesia in tonsillectomy; preliminary communication). Revista de la Facultad de ciencias médicas de la Universidad nacional de Cordoba, 1953, 11: 3-6, p. 627-631.

COMINSKY, N. C.: The effect of demero and morphine on the histologic: tructure of mouse tissues. Texas Reports on Biology an d Medicine, 1955, 13: 2, p. 222-233.

COOK, A. H.; REED, K.J.: No. 98: Experiments in the piperidine series. Journal of the Chemical Society, 1945, I, p. 399-402.

COSTA, P. J.; BONNYCASTLE, D. D.: The effect of levallorphan tartrate, nalorphine HCl and WIN 7681 (l-allyl-4-phenyl-4-carbethoxy-piperidin), on respiratory depression and analgesia induced by some active analgetics. Journal of Pharmacology and Experimental Therapeutics, 1955, 113: 3, p. 310-318.

CRIMENI, R.: Osservazioni cliniche sull'azione pre-anestetica del cliradon (Clinical observations on the pre-anesthetic effects of cliradon). Gazzetta medica italiana, 1953, 112: 8, p. 203-206.

CRIPPS, J. A. R.; HALL, B.; HAULTAIN, W. F. T.: Analgesia in labour; record of 102 cases treated with pethidine. British Medical Journal, 1944, No. 4371, p. 498-500.


DEXEUS TRIAS DE BES J. M.; SEGUR FERRER, J. M.: La associación largactil-dolantina-pituitrina en la conduccion del parto. (Combined largactil, dolantin and pituitrin in management of labour). Revista Española de Obstetrica y Ginecologia, 1955, 14: 81, p. 132-137

DIETRICH, H.: Klinische Erfahrungen mit einem neuen synthetischen Spasmolyticum und Analgeticum (Clinical experiments with a new synthetic analgesic). - Deutsche medizinische Wochenschrift, 1939, 65, p. 969-970.


EIDINOVA, M. B.: Primenenie promedola pri zabolevaniakh nervnoi sistemi (Use of promedol in diseases of the nervous system). Sovietskaia meditsina, 1954, 18: 11, p. 12-14.

ELLIOTT, H. W.: Comparative effects of 1,1- diphenyl-l-(dimethylamino -isopropyl)- bu-temone-2 (10820) demerol and morphine on the respiration of rat cerebral cortex slices. Federation Proceedings, 1947, 6 Part II, p 327-328.

ERLENDSSON, V.: Dolantin "Bayer ". Ugeskrift for Laeger, 1940, 102; p. 1330-1331.


FEHER, V.; BRUTAR, V.: Uziti dolsinu pri porodu (Use of dolsin in labour). Ceskoslovenska gynaekologie,1953, 18 : 4, p. 360-372.

FERRER, M. L.; SOKOLOFF, L.: The antidiuretic effect of morphine and Demerol in congestive heart failure. American Journal of medical science,1947, 214 : 4, p. 372-384.

FERRON, M.: Nisentil; analgésique obstétrical. Union Médicale du Canada,1955, 84 : 4, p. 431-433.

FINKELSTEIN, J.; LEE, J.: Piperidine derivatives. U. S. Patent No. 2,686,784, 17 August 1954 (Hoffmann-La Roche Inc.).

FITZGERALD, G.; McARDLE, B.: Effect of pethidine on pain in neurological cases. Lancet,1943, No. 6236, p. 296-297.

FORTI, D.: Procaina e dolantinici per via endovenosa in anestesia ed analgesia postoperatoria (Intraveinous procaine and dolantinin anesthesia and postoperative analgesia). Minerva Anestesiologica,1953, 19 : 8, p. 216-217.

FOSTER, R. H. L.; CARMAN, A. J.: Studies in analgesia: piperidine derivatives with morphine-like activities. Journal of Pharmacology and Experimental Therapeutics,1949, 91 : 3, p. 195-209.

FROMMEL, E.; RADOUCO-THOMAS, C.: De l'incidence des ganglioplégiques sur la prépararion de la narcose au pentothal par la morphine et le dolosal; du danger des opiacés. Praxis,1955, 44 : 18, p. 407-409.


GALLEN. B.; PRESCOTT, F.: Pethidine as an obstetric analgesic-a report on 150 cases. British Medical Journal,1944, No. 4335, p. 176-179.

GAMMELTOFT, A.; JOHANSEN, S. H.; RUBEN, H.: Pethidin ved cystoskopi; erfaringer med pethidin intravenost ved endoskopi af urethra og blaere hos maend (Pethidine in cystoscopy; experience with intravenous pethidine in endoscopy of male urethra and bladder). Ugeskrift for Laeger,1 953, 115 : 39, p. 1448-1449.

----------------; Intravenous pethidine for oesophagoscopy and gastroscopy. Anaesthesia,1953, 8 : 3, p. 194.

GEFTER, A. I.; MATUSOVA, A. P.: Primenenie tifen-promedola pri koronarnoi bolezni (Use of tiphen-promedol in coronary disease). Sovietskaia Meditsina,1955, 19 : 8, p. 22-25.

GLAZEBROOK, A. J.; BRANWOOD, A. W.: Clinical trials of β-pethidine. Lancet,1945, 249 : 6374, p. 528-529.

GORDON, G. S.; DIXON, A. B.: Observations on Demerol as an obstetric analgesic. American Journal of Obstetrics and Gynecology,1943, 45,p. 320.

GREBENNIK, L. I.: (Elimination of promedol from the body). Farmakologiya Toksikologiya,1954, 17 : 4, p. 48-51.

GYERMEK, L.: Studies on cholinergic blocking substances. VIII. Pharmacological actions of certain polymethylene-, bis- and azapentylenebis-pyrrolidine and piperidine derivatives. Acta Physiologica Academiae Scientiarum Hungaricae,1955, 8 : 1, p. 49-60.


HALLE, J.; DECHENE, J. P,; MONTMINY, L.; PARADIS, G.: Le nisentil en bronchoscopie. Laval médical,1955, 20:1, p. 5256.

HARDY, J. D.; McKEEN CATTELL: Measurement of pain threshold raising action of aspirin, codeine and meperidine (Demerol). Federation Proceedings,1950, 9 : 1, Part I, p. 282.

HARVEY, W. P.; BERKMAN, F.; LEONARD, J.: Caution against the use of meperidine hydrochloride (isonipecaine, demerol) in patients with heart disease, particularly auricular flutter. American Heart Journal,1955, 49 : 5, p. 758-769.

HECHT, H.; NOTH, P. H.; YONKMAN, F. F.: Demerol; clinical observations. Journal of the American Medical Association,1943, 121 : 16, p. 1307.

HEIDT, T. J.; DALLIS, N. P.; O'CONNELL, W.J.: The use of Demerol in artificial fever. American Journal of Psychiatry,1945, 101 : 6,p. 789-792.

HERSCHFUS, J. A.; SALOMON, A.; SEGAL, M. S.: The use of demerol in patients with bronchial asthma. Annals of Internal Medicine,1954, 40 : 3, p. 506-515.

HOCH, D.; KARRER, P.: Synthèse de plusieurs homologues de la methyl-piperidine. Helvetica Chimica Acta,1954, 37,p. 397-402.

HORÁKOVÉ, Z.; VOTAVA, Z.: Analgetické účinek morfinu, dolsinu a mecodinu pri ruznem zpusobu podání farmakologické studie (Analgetic effect of morphine, dolsin and mecodin in various ways of application; a pharmacological study). Ceskoslovenské Farmacie,1955, 4: 3, p. 131-133.

HURLBUT, D. B.; D1LLE, J. M.: The effect of nisentil upon the intra-uterine respiratory movements of the rabbit fetus. Anesthesiology,1952, 13 : 1, p. 71-76.

----------------; ----------------: The effect of nisentil upon the intra-uterine respiratory movements of the rabbit fetus. Journal of Pharmacology and Experimental Therapeutics,1951, 103:4, p. 348.


IZAR, G.; IENZI, S.: Studi sulla Dolantina. (Study on Dolantine). Rassegna internaz, di clinica e terapia,1941, 22,p. 213-221, 251-256.


JENSEN, K. A.; LUNDQUIST, F.; REKLING; WOLFFBRANDT, C. A.: Ein neuer Typus von Piperidin Derivaten mit analgeter und spasmolyter Wirkung (A new type of piperidine-derivative with analgesic and spasmolytic activity). Chemisches Zentralblatt,1944, I. 115 : 5, p. 297-298.

JESSEN, H.: Dolantin in recurrent hiccups. Journal of the American Medical Association,1942, 118:8, p. 674-675.

-;Om Dolantin. Ugeskrifi for Laeger,1940, 102,p. 1326-1328.


KLEIN, E. K.: Erfahrungen mit Dolantin, einem myotrop und neurotrop wirkenden Spasmolytikum (Experience with Dolantin, a Spasmolytic working as myotrop and neuro-trop). Münchener medizinische Wochenschrift,1939 2, p. 1676.

KRACHEEL,E.: Die Leistungsfähigkeit der Blutnarkose, ein Beitrag zum Narkoseproblem der chirurgischen Praxis (Potentiation of intraveinons anesthesia, a contribution to the anesthesia problem of surgical practice). Zentralblatt für Chirurgie,1955, 80 : 10, p. 398-405.

KUCHER, I.: Zwei Fälle von Dolantinsucht. (Two cases of addiction to dolantin). Klinische Wochenschrift,1940, 19;p. 688-489.

KUNZ, T.: Die Dolantin-Evipan-Lachgas-narkose mit My 301 als Muskelrelaxans (Dolantin-evipan nitrous oxide anesthesia with My 301 as a muscle relaxant). Medizinische,1953, No. 48, p. 1555-1556.

KWARTLER, C. F.: U.S. patent No. 2,634,275, 7 April 1953. 4-acylamino-l-alkyl-4-phenyl-piperidines and method of making same.


LAGARDE, L. A.; ORTIZ DE LA PENA, R.; BRAVO SERRADELL, O.: Tres drogas auxiliares en obstetricia (Three auxiliary drugs in obstetrics). Ginecologia y Obstetricia de Mexico,1955, 10 : 2, p. 140-150.

LEE, J.; ZIERING, A.; BERGER, L.; HEINEMAN, S. D.: Studies on the synthesis of Analgesic compounds. Jubilee Volume Emil Barell,(Hoffmann-La Roche), 1946, p. 265-305.

LEWIS, J. R.: Action of l-methyl-4-(3-Hydroxy phenyl)-4-piperidyl ethyl ketone on the gastrointestinal tract. Proceedings of the Society for Experimental Biology and Medicine,1949, 71: 2,p. 300-303.


McELVAIN, S. M.; DICKINSON, W. B.; ATHEY, R.: Piperidine derivatives XXV. Reaction of certain 3-substitutes l-methyl-4-piperidones with organometallic compounds. Journal of the American Chemical Society,1954, 76, p. 5625-5633.

----------------; BERGER, R. S.: Piperidine derivatives. XXVII. The condensation of 4-piperidones and piperidinols with phenols. Journal of the American Chemical Society,1955, 77:10, p. 2848-2850.

MARTIN, C.: L'anesthésie de base diparcoldolosal en chirurgie gériatrique et chez le malade représentant un manvais risque. Anes-thésie et Analgésie,1955, 12: 2, p. 335-347.

Motatovo MATSUMOTO; Yasumichi KISHINOUXE; Iwao YAMAZAKI; Yoshio NAKAMURA: Synthesis of N-ethylpiperldine. Coal Tar,1954, 6, p. 198-201.

MOREL-FATIO, D.: A propos de 200 cas d'anesthésie de base (diparcol-dolosal)+ locale en chirurgie réparatrice. Anesthésie et Analg?ie,1955, 12 : 2, p. 348-357.

MORISOT, D.: L'association diehazine-p?hidine I. V. (dipdol) comme anesth?ie de base. Anesthésie et Analgésie,1955, 12:2, p. 365-368.


NAZAROV, Z. N.; NOKOLOV, D. V.; RAKCHEEVA, V. N.: Geterotsiklicheskie soedinenu?ia. XXX. Stereoizomeriia 2, 5-di-metil-4-piperidola, 1, 2, 5-trimetil-4-piperidola i ikh proizvodnykh (Heterocyclic compounds. XXIX. Stereoisomers of 2, 5-dimethyl-4-piperidol, 1, 2, 5-trimethyl-4-piperidol and their derivatives). Izvestia Akademii Nauk SSSR otdelenie Khissicheskikh Nauk,1954, No. 1, p. 80-94.

NICKERSON, M.; GOODMAN, L. S.: Synergistic isonipeca ?ne-amphetamine analgesia. Federatiuo Proceedings,1947, 6 : 1, part II p. 360.


ORKIN, L. R.; EGGE, R. K., ROVENSTINE, E. A.: Effect of nisentil, meperidine and morphine on respiration in man. Anesthesiology,1955, 16: 5, p. 699-707.


PASSMORE, G. G.; SANTA CRUZ, E. W.: The use of intravenous and intramuscular injections of demerol and scopolamine in labor and delivery. American Journal of Obstetrics and Gynecology, 1954, 68 : 4, p. 998-1008.

PATERSON, S. J.; PRESCOTT, F.: Nalorphine in the prevention of neonatal asphyxia due to maternal sedation with pethidine. Lancet,1954, 266 : 6810, p. 490-493.

PERRINE, T. D.; MAY, E. L.: Synthesis of 6-dimethylamino-4, 4-diphenyl-heptane and other compounds related to Demerol. Journal of Organic Chemistry, 1954, 19,p. 773-779.

PÓRSZÁSZ, J.; VENULET, .J.; GIBSZER PÓRSZÁSZ , K.: Untersuchungen über die Synergisierbarkeit der Analgetika; Wirkung des Doryls und Physostigmins auf die Verteilung'des Dolantins im Organisnms (Studies on synergism of analgesics; effect of doryl and physostigmine on the distribution of dolantin in the organism). Acta physiologica academiae scientiarum hungaricae, 1954, 5 : 3-4, p. 509-519.

PRESTON, F. S.: Anaesthesia for mitral valvotomy. British Journal of anaesthesia, 1953, 25 : 4, p. 299-314.

PRYOR, W. J.: Pethidine in anesthesia. New Zealand Medical Journal, 1953, 52 : 291, p. 398-400.


RANDALL, L. O.; LEHMANN, G.: Pharmacological studies on analgesic piperidine derivatives. Journal of Pharmacology and Experimental Therapeutics, 1948, 93 : 3, p. 314-328.

RASOR, R. W.; CRECRAFT, H. J.: Addiction to Meperidine (Demerol) hydrochloride. Journal of the American Medical Association, 1955, 157 : 8, p. 654-657.

REISINGER, F.: Das neue Analgeticum und Spasmolyticum Dolantin (A new analgesic and spasmolytic; dolantin). Wiener medizinische Wochenschrift, 1940, 90,p. 400.

ROBERTS, H.; WRIGLEY, F.: Nisentil in obstetrics; clinical trials with a new analgesic. Journal of Obstetrics and Gynaecology of the British Empire, 1953, 60 : 4, p. 538-540.

ROBY, C.; SCHUMANN, W. R.; Demerol (S-140) and scopolamine in labor: a preliminary report. American Journal of Obstetrics and Gynecology, 1943, 45,p. 318.

ROJAS, N.; BELBEY, J.: Hábito tóxico y dolantina (Drug addiction and dolantin). Semana Médica, 1941, 2, p. 616-618.

ROSENTHAL; H .:Beobachtungen zur Bekämpfung des Wundschmerzes mit dem neuen Analgeticum Dolantin (Remarks on fighting traumatic pain with a new analgesic, Dolantin). Münchener medizinische Wochenschrift, 1939, 86,p. 1079-1080.

ROST, H.; SIEVEKT, C.: Die Einwirkung von Phenotiazinderivaten und Dolantin auf Diurese und Nierenclearance (Effects of phenothiazine derivatives and Dolantin on diuresis and kidney clearance). Zentralblatt fur Gynäkologie, 1954, 76 : 49, p. 2148-2153.

ROUCHY, R.; BREIL, J. F.: Accouchement dirigé: la perfusion d'extrait post-hypophysaire associée ou non à d'autres médications. Gynécologie et Obstétrique, 1954, 53 : 3, p. 364-374.

RUDDY, A.W.; BISHOP, H.W.: Antispasmodics. III. N-methyl-2(4)-W-R- w-phenylaltyl piperidines and 2-R-2-Phenyl-4(5)-(N-methyl-4-piperidyl)-alkanenitriles. Journal of the American Chemical Society, 1952, 74 : 8, p. 1919-1921.

RUSTIA, G.; ALMEDA, L.: Demerol and scopolamine in obstetrics. Journal of the Philippine Medical Association, 1948, 24 : 2, p. 61-65.

RYPDAL, A.: Pethidin ved oesophagoskopi og bronchoskopi (Pethidine in oesophagoscopy and bronchoscopy). Tidskrift for den Norske laegerforening, 1953, 73 : 21, p. 809-812.


SCHAEFER, F.: Schmerzbekämpfung in der Chirurgie mit Dolantin (The suppression of pain in surgery through the use of dolantine). Deutsche medizinische Wochenschrift, 1939, 65,p. 970-972.

SCHAUMANN, O.: Ueber eine neue Klasse von Verbindungen mit spasmolytischer und zentral-analgetischer Wirksamkeit unter besonderer Berücksichtigung des 1-Methyl-4-phenyl-piperidin-4-carbonsäure-ethylesters (Dolantin) (A new class of compounds with spasmolytic and central analgesic action, particularly 1-methyl-4-phenylpiperidine-4-carboxylic acid ethyl ester). Archiv für experimentelle Pathologie und Pharmakologie, 1940, 196 : 2, p. 109-136.

SCHI?LER, V.: Dolantin. Ugeskrift for Laeger, 1940, 102,p. 1328-1330.

SCHLUNGBAUM, H.: Schmerzbekämpfung mit Dolantin, einem synthetischen hergestellten Spasmolytikum und Analgetikum (Suppression of pain through the use of dolantin, a synthetic spasmolytic and analgesic). Medizinische Klinik, 1939, 35,p. 1259.

SCHMITT, W.: Klinische Prüfung einer neuen Piperidin-Verbindung als Schlafmittel (Clinical trial of a new piperidine compound as soporific) ·Medizinische Klinik, 1955, 50 : 29, p. 1223-1224.

SCHMUTZ, J.; KUNZLE, F.: 1-Methyl-4-benzyl-piperidin-4-carbonsäure-ethylester und neue Synthese des l-Methyl4-cyano-piperidins (1-methyl-4-benzyl-piperidine-4-carboxylic acid ethylester and new synthesis of 1-methyl-4-cyanopiperidine). Helvetica chimica Acta, 1955, 38 : 4, p. 925-930.

SCHWARKE, R.: (Addiction to Dolantin). Deutsche Zeitschrift für die gesamte gerichtliche Medizin, 1941, 25,p. 17-23.

SCOTT, D.L.: Pethidine and gallamine alone in the treatment of fractured mandible. British Journal of Anaesthesia, 1955, 27 : 7, p. 393-397.

SHARTS, S. E.: KOTOVA, E. S.: Promedol v oftalmologicheskoi praktike (Promedol in ophthalmologic practice). Sovietskaia Meditsina, 1955, 19 : 2, p. 75-77.

SIGIDIN, I. A.: O boleutoliaiushtchem preparate promedole (The analgesic preparation promedol). Sovietskaia Meditsina, 1953, 17 :10, p. 25-27.

SOKOLOV, I.V.- Primenenie tifen-promedola pri stenokardii i nekotorykh drugikh zabolevaniiakh (Use of tiphen-promedol in stenocardia and some other diseases. Emploi du tiphen-promedol en stenocardie et quelques autres affections). Sovietskaia Meditsina, 1955, 19: 8, p. 26-28.

SONNEK, W.: Geburtserleichterung durch Dolantin (Use of dolantin in obstetrics). Deutsche medizinische Wochenschrift, 1941, 67 : 32, p. 868-871.

SOSTMAN, A.: Zur Ablösung des Morphin und seiner Abkömmlinge in der Gynäkologie durch Dolantin (Elimination of morphine and its derivatives in gynecology by means of Dolautin). Medizinische Welt, 1940, 14,p. 325.

SPITZER, W.: Obstetric analgesia with pethidine. British Medical Journal, 1944, No. 4335, p. 179-181.

SPROCKHOFF, O.: Dolantin in der Kinderheilkunde (Dolantin in pediatrics). Deutsche medizinische Wochenschrift, 1941, 67, p. 383.

STAHNKE, H. L.: Demerol as an anti-scorpion therapeutic agent. Arizona Medicine, 1954, 11 : 2, p. 51-52.

STROUD, M. W. III; LAMBERTSEN, C. J.; EWING, J. H.; KOUGH, R. H.; GOULD, R. A.; SCHMIDT, C. F.: The effects of aminophylline and meperidine alone and in combination on the respiratory response to carbon dioxide inhalation. Journal of Pharmacology and Experimental Therapeutics, 1955, 114: 4,p. 461-469.

SWERDLOW, M; FOLDES, F. F.; SIKER, E. S.: The effects of nisentil hydrochloride and levallorphan tartrate on cerebrospinal fluid pressure. British Journal of Anaesthesia, 1955, 27:5, p. 244-249.

----------------; ----------------; ---------------- The effects of nisentil HC1 (alphaprodine HC1) and levallorphan tartrate on respiration. American Journal of the Medical Sciences, 1955, 230:3, p. 237-250.

SZIRMAI, E.: Der Zusammenhang zwischen der Blutgerinnung und der schmerzstillenden Wirkung des Dolantins (Relation between blood coagulation and palliative effect of Dolantin). Pharmazie,1955, 10:1, p. 14-18.

----------------; BASUSZ, E.; NYIRI, I.: (Action of the new analgesic agent Depridol on pain sensation, duration of childbirth, and efficiency of parturition). Pharmazie,1954, 9,p. 116-123.


TEARE, F. W; HUSTON, M. J.: Effect of certain drugs on skeletal muscle. Archives internationales de pharmacodynamie et de thérapie, 1953, 95 : 3-4, p. 437-443.

TRIFILIO, A. A.; HUDSON, P. B.: A clinical study of 100 cases in which nisentil hydrochloride was used for analgesia to facilitate cystoscopy and other urological procedures. Journal of Urology, 1955, 74 : 2, p. 246-251.

TRIPOD, J.; SURY, E.; HOFFMANN, K.: Zentralerregende Wirkung eines neuen Piperidindetivates (Analeptic effect of a new piperidine derivative). Experientia,1954, 10: 6, p. 261-262.

TUTWILER, F. B.; CHILD, R. G.; WRENN, S. N.: Potential analgesics and antispasmodics. I. Synthesis of open-chain analogs of Demerol. Journal of Organic Chemistry, 1954, 19,p. 910-918.


VIDIC, E.: Der Nachweis von Polamidon und Dolantin im Urin und ihre Treunung vom Morphin (Determination of Polamidon and Dolantine in urine and their separation from morphine). Archiv für experimentelle Pathologie und Pharmakologie, 1951, 212:5-.6, p. 339-351.

VOEVODINA, O. N.: Vliianie Promedola na uslovnoreflektornuiu decatel'nost' (Influence of promedol on conditioned reflex action). Farmakologiya i Toksikologiya, 1954, 17:1,p. 8-12.

VOGT, K.E.: Dolantin zur Schmerzbekämpfung bei inneren Erkrankungen (Dolantin for pain control in internal diseases), Medizinische Klinik, 1940, 23, p. 622.


WALTON, E.; GREEN, M. B.: Search for new analgesics. I. Homologs of pethidine and related compounds. Journal of the Chemical Society, 1945, I, p. 315-319.

WAY; GRUBBS, R, C.; SWANSON, R.: The effects of isonipecaine (demerol) on auricular fibrillation. Federation Proceedings, 1947, 6 : 1, Part II, p. 382.

WAY, E. L.; GIMBLE, A. I.; LIGON Jr. E. W.: The tissue distribution of isonipecaine (demerol) Federation Proceedings, 1947, 6 : 1, Part II, p. 381-382.

WAY, E.L.; BINDER, S. S.; MICHAEL, A. H. One way isonipecaine irimethadione antagonism. Federation Proceedings, 1947, 6 : 1, Part II, p. 381.

WEINER, E.: Nisentil; a new basal analgesic for oral surgery. International Journal of Anesthesia, 1955, 2 : 4, p. 245-249.

WIDDOWSON, H. R.; AQUINO, T. D.; VIRTUE, R. W.: Recovery time following demerol or pentothal supplementation of nitrous oxide anesthesia. Anesthesiology,1955, 16:5, p. 747-750.

WIEDER, H.: Addiction to meperidine hydrochloride (demerol hydrochloride), Report of 3 cases. Journal of the American Medical Association, 1946, 132 : 17, p. 1066-1068.

WINDER, A. V.: A preliminary test for analgetic action in guinea pigs (morphine, demerol). Archives internationales de pharmacodynamie et de thérapie, 1947, 74 : 2, p. 176-192.

----------------; Quantitative evaluation of analgetic action in guinea pigs. Morphine ethyl 1 - methyl - 4 - phenylpiperidine - 4- carboxylate (Demerol) + acetylsalicylic acid. Archives internationales de pharmacodynamie et de thérapie, 1947, 74 : 3/4, p. 219-232.

WULFSOHN, N. L.: Intravenous pethidine for hiccup. Lancet,1954, 267 : 6832, p. 289.


YONKMAN, F. F.; NOTH, P. H.; HECHT, H. H.: Some pharmacologic features of Demerol. Proceedings of the Central Society for Clinical Research, 1942, 15,p. 89-90.


ZHEREBTSOV, L. A.: Klinicheskoe issledovanie novogo obezbolivaiushchego preparata izopromedola (Clinical evaluation of a new analgetic preparation [isopromedol]). Sovietskaia Meditsina, 1955, 19 : 8, p. 29-33.

C. Methadone and related compounds


ANOSOV, N. N.; PISSAREVA, N. A.: Lechanie fenadonom bol'nykh s nevralgicheskim sindronom razlichnogo proiskhozhdeniia (Therapy of neuralgic syndromes of various origins with phenadon). Sovietskaia Meditsina, 1954, 18 : 11, p. 11-12.

ANWEILER. H.: Biologischer Nachweis von Polamidonabusus (Biological detection of polamidon addiction). Klinische Wochenschrift, 1954, 32 : 5-6, p. 138-139.


BECKETT, A. H.; CASY, A. F.: The structure of 6-methylmethadone. Journal of Pharmacy and Pharmacology, 1955, 7 : 3, p. 204-206.

BLICKE, F. F.; TSAO, E. P.: Preparation of several analogs of amidone and isoamidone. Journal of the American Chemical Society, 1954, 76,p. 2203-2206.

BURROUGHS, H. E.: Methadone narcosis in dogs. Journal of Small Animal Medicine, 1953, 1 : 7, p. 301-303.


COOK, L.; NAVIS, G.; FELLOWS, E. J.: Enhancement of the action of certain analgesic drugs by diethylamino ethyl 2,2-diphenylvalerate hydrochloride (SKF 525-A). Journal of Pharmacology and Experimental Therapeutics, 1954, 112,p. 473-479.


EASTON, N. R.: Structure of isoamidone. Journal of the American Chemical Society, 1954, 74,p. 5772.

----------------; FISH, V. B.: Synthesis of 5-dimethylamino-4,4-diphenyl-2-pentanol. American Chemical Society, 126th Meeting, 1954, p. 27N-28N.

---------------- ,----------------, Decomposition of quaternary salts. II Stereospecificity in the isomethadone series. Journal of the American Chemical Society, 1954, 76, p. 2836-2837.

EDDY, N. B.: A new morphine-like analgesic. Journal of the American Pharmaceutical Association, 1947, 8 : 11, p. 536-540.


GERO, H.: Steric considerations on the chemical structure and physiological activity of metha- done and related compounds. Science,1954, 199:3082, p. 112-113.

GRIEBEL, C.: Nachweis von Polamidon (Determination of Polamidon). Pharmazeutische Zeitung, 1950, 86,p. 540.


HAIBACH, A.: Gibt es eine Ticardasucht? (Ticarda addiction). Deutsches medizinisches Journal, 1955, 6 : 3-4, p. 117-119.

HERR, F.; PÓRSZÁSZ, J.: Uber die Wirkung einiger Derivate des Polamidons (Action of some derivates of polamidon). Naunyn-Schmiedeberg's Archiv für experimentelle Pathologie und Pharmakologie, 1950, 210 : 3, p. 294-304.

HOFFMANN, W.: Die Analytik des Polamidon (Analysis of polamidone). Arzneimittel-Forschung,1953, 3 : 7, p. 364-368.

----------------; Der Nachweis des Polamldon in Postonalsuppositorien (Detection of Polamidon in postonal suppositories). Arzneimittel-Forschung,1953, 3 : 8, p. 440-441.

HOWE, E. E.; BROOK, B.; TISHLER, M.: Salts of D-amidone with an optically active acid and process for revolving DL-amidone. U.S. Patent No. 2,644,010, 1953.


ISBELL, H.; FRASEI, H. F.: Addictive properties of methadone derivatives. Federation Proceedings, 1954, 13 : 1, Part 1, p. 369-370.


KNOBLAUCH, G.; KRAUSE, D.: (Experimental and clinical investigations on the effect of polamidone [methadone] on the dog). Tierärztliche Umschau, 1950, 5, p. 134-138.


LEIMBACH, D. G.; EDDY, N. B.: Synthetic analgesis. III. Methadols, isomethadols and their acyl derivatives. Journal of Pharmacology and Experimental Therapeutics, 1954, 110:2,p. 135-147.


MAY, E. L.; PERRINE, T. D.: Wagner rearrangement of z-DL-6-dimethylamino-4, 4-diphenyl-3-heptonal (z-DL-methadol). Journal of Organic Chemistry, 1953, 18,p. 1572-1577.

MILLER, J, W; ELLIOTT, H. W.: In vitro studies on the diphasic action of methadone. Journal of Pharmacology and Experimental Therapeutics, 1954, 110 : 1, p. 106-114.


OSTERWALD, K. H.: Zwei Beobachtungen von Atemlähmung nach Polamidonmissbrauch (Two observations of respiratory paralysis after overdose of polamidone). Sammlung von Vergiftungsfallen; Archiv für Toxicologie, 1953, 14 : 6, p. 349-351.


PAVLOVA, N. IA.: (Action of phenadone on the bloodvessels of the detached rabbit ear [not unnerved]). Farmakologiia i Toksicologiia, 1955, 18 : 1, p. 27-28.

PERRINE, T. D.: Synthesis of compounds related to the methadols. Journal of Organic Chemistry, 1953, 18 : 7, p. 898-903.

PHATAK, N. M.; DAVID, N. A.: Addiction potentialities of some methadone analgesics and alpha acetylmethadol as determined by their hyperglycemic responses in rabbits. Current Researches in Anesthesia and Analgesia, 1953, 32:4, p. 242-249.

PIOTTI, F.: Nouveaux analogues du chlorhydrate de methylamino 4-4-dyphényl-3-heptanone. Minerva Medica, 1951, I, p. 449-451.

PRATT, J. H.; WELCH, J. S.: Hyatrobal and methadone hydrochloride in preoperative preparation of patients. Journal of the American Medical Association, 1955, 157 : 3, p. 231-234.


RODES DE SISTERNES, L.: Analgesia en el parto con methadon-escopolamina (Methadon-scopolamine analgesia in labour). Toko-Ginecologia Práctica, 1955, 14 : 133, p. 295-299.


SALM, H.: Beobachtungen bei Polamidonsüchtigen, insbesondere über psychische Veränderungen nach Polamidonmissbrauch (Observations on polamidon addiction, especially on psychic changes after misuse of polamidon). Nervenarzt,1953, 24 : 4, p. 143-148.

SALVESEN, B.: Methadon Fargereaksjoner og fotometrisk bestemmelse (Methadone colour reactions and photometric estimation). Meddelelser fra Norsk famaceutisk selskap, 1952, 14,p. 1-11.

SCHILDKNECHT, E. A.; BROWN, E. V.: Synthesis of 2-thiopene analogs of amidone and isoamidone. American Chemical Society, Abstract of papers, 126th meeting, 1954, p. 27N-28N.

SLETZINGER, M; CHAMBERLIN, E. M.; TISHIER, M.: Synthesis of isomethadone. Journal of the American Chemical Society, 1952, 74 : 22, p. 5619-5620.

----------------; TISHLER, M.: B. Resolution of isoamidone with (Lx)-p-nitrobenzoyl-glutanic acid. U.S. Patent No. 2,625,564, 1954.

SPEETER. M. E .:Amidone amines and related derivatives. U.S.PatentNo. 2,632,762, 1954.

STEPHAN, W.: Polamidon in der Behandlung des Tetanus (Polamidon in tetanus treatment). Die Medizinische, 1953, No. 31-32, p. 1009-1011.

STOUGHTON, R. W.: An isomer of amidone. U.S. Patent No. 2,670,375, 1954.

SUNG, C. Y.; WAY, E. L.: The fate of the optical isomers of alpha acetyl methadol. Journal of Pharmacology and Experimental Therapeutics, 1954, 110 : 3, p. 260-270.


VIDIC, E.: Der Nachweis von Polamidon und Dolantin im Urin und ihre Trennung vom Morphin (Determination of Polamidon and

Dolantin in the urine and their separation from Morphine). Archiv für experimentelle Pathologic und Pharmakologie, 1951, 212:5-6, p. 339-351.


WALTON, E.; OFNER, P.; THORP, R. H.: New analgesics. III. Homologs of amidone, isoamidone, and some related compounds. Journal of the Chemical Society, 1949, p. 648-655.


ZAUGG, H. E.; HORROM, B. W.; VERNSTEN, M. R.: The Mannich reaction of diphenylacetonitrite. Products and derivatives. Journal of the American Chemical Society, 1953, 75 : 2, p. 288-291.

D. Morphinan and morphine synthesis


AKCASU, A.: Yoni bit analjezik drog metorphinana (Dromoran Roche) (A new analgesic, 3-hydroxy-N-methylmorphinan [Dromoran Roche]). Tip fakültesi mecmuasi, 1954, 17 : 4, p. 530-536.

ANONYMOUS: New approved drugs 1 levorphan tartrate, levo-dromoran tartrate, etc. University of Michigan Medical Bulletin, 1954, 20:1, p. 22-25.


BAGGESGAARD-RASMUSSEN, H.: Om morphinets konstitution og syntese samt om nogle syntetiske analgetica (Constitution and synthesis of morphine and some synthetic analgesics). Dansk tidskrift for farmaci, 1954, 28 : 7, p. 133-155.

BELLEAU, B.: A new synthetic approach to the morphine structure. Journal of the American chemical society, 1953, 75 : 5, p. 1159-1163.

BOZZA, M.: L'N-metil-morfinano a complemento dell'anestesia N 2O-O 2-pentothal (N-methylmorphinan as adjuvant in nitrous oxide-oxygen-pentothal anesthesia). Minerva chirurgica, 1954, 9 : 7, p. 319-327.

BREZINSKI, J. J.: Use of the internal Michael reaction in the synthesis of morphine analogs. University microfilms, Publ. No. 10046, 108 pp. Dissertation Abstracts, 1954, 14, p. 1921-1922.

BROSSI, A.; HAEFLIHER, O.; SCHNIDER, O.: Oxy-morphinane. 6. Die papierchromatographische Bestimmung von Morphinanderivaten und die Verfolgung ihrer Ausscheidung beim Hund (Hydroxy-morphinan: 6. Paper chromatography of morphinan derivatives and their excretion in urine). Arzneimittel-For-schung,1955, 5 : 2, p. 62-66.

BROWN, A. K.: Levorphan in anaesthesia. British Medical Journal, 1954, No. 4894, p. 967-969.


CALDERONI, C.; CAVACIUTI, P.: L'idrossi-N-metil-morfinano in anestesia per interventi di chirurgia plastica (3-hydroxy-N-methylmorphinan in anesthesia for plastic surgery). Ospedale maggiore, 1955, 43 : 5, p. 231-234.

CALIGARI, G.: Il tartrato di 3-ossi-N-metilmorfinano (dromoran) nella pratica clinica (3-hydroxy-N-methylmorphinan tartrate [dromoran] in clinical practice). Gazetta medica italiana, 1955, 114:5, p. 113-116.

CANDELERO, G.; CARPINO, A.: (Tartrate of 3-hydroxy-N-methylmorphinan as pre anesthetic and support anesthesia in neuro-surgery). Policlinico,1955, 63:p. 247-258.

CAPPELLO, G.: DI PASQUALE, S.: Traitement de la toux avec le bromhydrate de dextrométhorphane (Romilar) en tuberculose. Schweizerische Zeitschrift für Tuberkulose, 1955, 12:1, p. 80-88.

CASS, L. J.; FREDERICK, W. S.: Evaluation of a new antitussive agent (dextro-3-methoxy-N-methylmorphinan hydrobromide). New England Journal of medicine, 1953, 249:4, p. 132-136.

COSTA, P. J.; BONNYCASTLE, D. D.: Effect of levallorphan tartrate, Nalorphine HCl and WIN 7681 (1-Allyl-4-phenyl,4-Carbethoxypiperidine) on respiratory depression and analgesia induced by some active analgetics. Journal of pharmacology and experimental therapeutics, 1955, 113 :3, p. 310-318.

COUNCIL on pharmacy and chemistry : New and unofficial remedies: levorphane tartrate. Journal of the American medical association, 1954, 156 : 3, p. 250-251.

CREHAN, A.: Methorphinan as a supplementary anaesthetic medium. Journal of the Irish medical association, 1954, 34:201, p. 74-75.


ELAD, D.; GINSBURG, D.: Synthesis of morphine. Journal of the American chemical society, 1954, 76, p. 312-313.

----------------; : Synthesis in the morphine series. VI. Synthesis of morphine. Journal of the chemical society, 1954, p. 3052-3056; Chemical abstracts, 48, 12056 b.

EMANUELLI, H.; MACCAGNO, V.: L'uso del tartrato di 3-idrossi-N-metilmorfinano quale prenarcotico (Use of 3-hydroxy-N-methylmorphinan tartrate as pre-narcotic. Emploi du tartrate d'hydroxy-3-N-methyl-morphinane comme pré-anesthésique). Acta anaesthesiologica, 1955, 6: 2, p. 151-156.

EMMONS, M. S.; GOSLIN, F. B.; SAFLEY, M. W.; TIDRICK, R,. T.: Use of levorphan tartrate for relief of postoperative pain; preliminary report. Journal-Lancet,1955, 75: 1,p. 29-31.

ENGELMEIER, M. P.: (Attempted suicide with E605 and treatment with an allyl derivative of the morphinan group). Medizinische Klinik, 1954, 49,p. 1996-1998.

ERNE, K.: Den första morfinsyntesen genomförd (The first synthesis of morphine). Farmacevtisk Revy, 1952, 51,p. 289-294.


FARBENFABRIKEN BAYER: Verfahren zur Herstellung von 1-benzyl-1,2,3,4,5,6,7,8-okta-hydro-isochinolin (Process for manufacture of 1 -benzyl-1,2,3,4,5,6,7,8-octahydro-isoquinolin). Swiss Patent 289377, 1 July 1953.


GAARD, R. C.: Postoperative use of levo-dromoran tartrate. Journal-Lancet,1955, 75: 7, p. 309-310.

GROSS, E. G.; HAMILTON, W. K.: Preliminary observations on the effect of levallorphan on respiratory depression and analgesia of levorphan in man. Journal of laboratory and clinical medicine, 1954, 43: 6, p. 938-941.

GRUBER, C. M. Jr.: Effect of levallorphan tartrate upon the toxicity of morphine. Proceedings of the Society for experimental biology and medicine, 1955, 88 : 2, p. 189-191.

GRUESSNER, A.; SCHNIDER, O.: Anticough agents comprising (+)-3-hydroxy-N-methymorphinan ethers. British Patent No. 713146, 4 August 1954.


HENECKA, H.: Neue Synthesen in der Morphinanreihe (New syntheses in the morphinan series). Justus Liebig' s Annalen der Chemie, 1953, 583:2, p. 110-128.

HOFFMANN-LA ROCHE & CO.: Morphinan derivatives and salts thereof. British Patent No. 685634, 7 January 1953.

----------------; ----------------; Isoquinoline derivatives. British Patents No. 685748,-749,-750, 7 January 1953.


KAYSER, F.: Konstitution und Synthese des Morphins (Constitution and synthesis of morphine). Part I* Chemiker Zeitung, 1953, 77: 19, p. 645-648; Part II. Ibid.,1954, 78: 2, p. 37-41.

KUMMER, A.: Praktische Erfahrungen mit einem neuen Hustenmittel Romilar Roche. (Practical experience with a new cough medicine Romilar Roche). Praxis,1955, 44: 6,p. 132.


LANDMESSER, C. M; FORMEL, P. F.; CONVERSE, J. G.: Comparative effects of a new narcotic antagonist (levallorphan tartrate) upon the respiratory responses to carbondioxide during narcotic and barbiturate depression in anesthetized man. Anesthesiology,1955, 16:4, p. 520-535.

LOEFFLER, A.; GINSBURG, D.: Open-chain analogs of morphine. Journal of the American chemical society, 1954, 76,p. 3731-3732.


MALORNY, G.: Zur Wirkungsweie spezifischer Morphinantagonisten 1. Die Beeinfiussung der zentralerregenden Wirkung yon Mor-phinverwandten und N-Methylmorphinan-Derivaten bei der Maus (Mode of action of specific morphine antagonists. 1. Influence on the central stimulating effect of morphine and N-methylmorphinan in mice). Arzneimittel-Forschung,1955, 5: 5, p. 252-259.

MALORNY, G.; OHNESORGE, F. K.: Zur Wirkungsweise synthetischer Morphinanderi-vate (Mode of action of synthetic morphinan derivatives). N. Sch. Archiv fiir Experimentelle Pathologie und Pharmakologie, 1955, 224:5-6, p. 81-82.

MAURER, H.: Die hustenstillende Wirkung von Verbindungen der Dromoranreihe (Cough controlling effect of compounds of the dromoran series. Effet de contrôle de la toux de certaines préparations de la série du Dromoran). Deutsche medizinische Wochenschrifi, 1955, 80: 10, p. 351-353.

MAY, E. L.; MURPHY, J. G.: Structures related to morphine. Synthesis of an analog of N-methylmorphinan. American chemical society (Abstracts), 126th meeting, 12-17 Sept. 1954, p. 18N-19N.

MAYER, W.: Klinische Erfahrungen mit dem neuen synthetischen Analgeticum Citarin Bayer (Clinical experiences with the new synthetic analgesic Citarin produced by Bayer). Medizinische Monatsschrifi, 1955, 9: 5, p. 319-320.

MURPHY, J. G.; MAY, E. L.: Structures related to morphine. I. 2-(2-dimethyl-ami-noethyl)-2-phenylcyclohexanone and derivatives. Journal qf organic chemistry, 1954, 19,p. 615-617; II. An isomer of N-methylmor-phinan. (E. L. MAY; J. G. MURPHY) Ibid.,p. 618-622.


PELLMONT, B.: The influence of different drugs on the analgesic activity of Levorphan. Journal of pharmacology and experimental therapeutics, 1954, 110:1, p. 42 (abstract).

PITTINGER, C.B.; GROSS, E.G.; RICHARD-SON, O. M: The effect of nalorphine levallor- phan and analogues of levallorphan upon the hyperglycemic response of dogs to levorphan. Journal of pharmacology and experimental therapeutics, 1955, 114:4, p. 439-444.

PITRE, D.: Una nuova sintesi della morfina (New synthesis of morphine). Il Farmaco, 1954, 9: 3, p. 183-186.


QUAGLIA, C.; FRANCO, L. G.: I1 1-idrossi-N-metilmorfinano, analgesico di sintesi, nei dolori da processi neoplastici (The synthetic analgesic agent 1-hydroxy-N-methylmorphinan in the control of pain caused by neoplastic processes. Gazetta medica italiana, 1954, 113:10, p. 297-301.


RADNAY, P. A.; HECHTER, R. H.: Effect of l-allorphan tartrate on respiratory depression during nitrous oxide-oxygen anesthesia supplemented by 1-Dromoran tartrate. Journal of the international college of surgeons, 1955, 23,p. 38-50.

RANDALL, L. O.; KRUGER, J.; CONROY, C.; KAPPELL, B.; RENSON, W. M: Peripheral effects of the optical antipodes of 3-hydroxy-N-methyl-Morphinan and some of their derivatives. N.-Schm. Archiv fiir experimentelle Pathologic und Pharmakologie, 1953, 220:1-2, p. 26-39,


SANTARATO, R.: Azione del farmaci sul metabolismo del piruvato nei feti e negli animali giovani. II. Morfina e morfinosimili di sintesi (Effect of drugs on the metabolism of pyruvate in fetuses and young animals. II. Morphine and synthetic morphine-like drugs). Bollettino della societé italiana di biologia sperimentale, 1953, 29:4, p. 628-630.

SCHALLEK, W.; WALZ, D.: Cardiovascular and central nervous system effects of the morphinan series (21344). Proceedings of the society for experimental biology and medicine, 1954, 87: 1, p. 233-236.

SCHNIDER, O.; GRUESSNER, A. (Hoff-mann-La Roche Inc.): Optically active 3-methoxy-N-methylmorphinans and their salts. United States Patent No. 2,676,177, 20 April 1954.

SCHNIDEK, O.; BROSSI, A.; VOGLER, K.: (Hydroxymorphinan. V. Optically active benzyloctohydroisoquinolines). Helvetia chimica acta, 1954, 37,p. 710-720.

SHORE, P. A.; AXELROD, J.; HOGBEN, C. A. M.; BRODIE, B. B.: Observations on the fate of dromoran in the dog and its secretion into the gastric juice. Journal of pharmacology and experimental therapeutics, 1955, 113:2 ,p. 192-199.


THOMAS, D. V.; TENNEY, S. M.: Effect of levorphan and levallorphan on the respiratory mechanism of normal man. Journal of pharmacology and experimental therapeutics, 1955, 113: 3 ,p. 250-255.

TUENNEKHOFF, F. K.; SCHWABE, H. K.: Untersuchungen zur Frage der Verwendbarkeit synthetischer Methoxy-methyl-morphinane; Beitrag zur Therapie der verschiedenen Hustenformen bei Lungentuberkulose (Possible use of synthetic 3-methoxy-N-methylmor-phinan; contribution to the therapy of the various types of cough in pulmonary tuberculosis). Klinische Wochenschrifi, 1955, 33:23 -24, p. 576-580.


VIDIC, E.: Nachweis und quantitative Bestimmung des Dromoran sowie seine Unterschei-dung von anderen stark wirkenden Analgetica in biologischem Material (Detection and quantitative determination of dromoran as well as its differentiation from other analgesics with powerful effect in biological material). Arzneimittel-Forschung,1953, 3: 8, p. 428-435.


YOUNG, D.C.; PLOEG, R. A. V.; FEATHER-STONE, R. M.; GROSS, E. G.: The interrelationships among the central, peripheral and anticholinesterase effects of some mor-phinan derivatives. Journal of pharmacology and experimental therapeutics, 1955, 114: 1, p. 33-37.


ZINDLER, M.; GANZ, P.: Ein Antidot der Opiate; die antagonistische Wirkung von (-)3-Oxy-N-allyl-morphinan (Ro 1-7700) auf die Atemdepression nach hohen Dosen von Morphin und Morphin-Abkömmlingen (An antidote against opiates; the antagonistic effect of (-) hydroxy-N-allylmorphinan (Ro-1-7700) on respiratory depression after high doses of morphine and morphine derivatives). Deutsche medizinische Wochenschrift, 1955, 80:12, p. 410-412.

E. Dithienylbutenylamines and miscellaneous synthetics


EDDY, N. B.; LEIMBACH, D.: Synthetic analgesics II. Dithienylbutenyl- and dithienyl-butylamines. Journal of pharmacology and experimental therapeutics, 1953, 107:3, p. 385-393.


FLINTAN, P.; KEELE, C. A.: Clinical trial of some analgesic dithienylalkanylamines (abstract). Journal of pharmacology and experimental therapeutics, 1954, 110:1, p. 18.

----------------; ----------------: Analgesic and other actions of some dithienylbutenyl-amine compounds in man . British Journal of pharmacology, 1954, 9:1, p. 106-117.


GREEN, A. F.: Analgesic and other properties of 3: 3-Dithienylalkenylamines. British journal of pharmacology and chemotherapy, 1953, 8: 1, p. 2-9.


ISBELL, H.; FRASER, H. F.: Actions and addiction liability of the dithienylbutenylamines in man. Journal of pharmacology and experimental therapeutics, 1953, 109:4, p. 417-421.


SUGIMOTO, Norio; SAITO, Seiichi; OSHIRO, Susumu: Synthetic analgesics. IV. Synthesis of 1,1-di(2-thienyl)-2-methyl-3- (tertiary-amino) propenes. Journal of the Pharmaceutical society of Japan, 1953, 73, p. 1381-1383.