Opium: a plant-based drug harvested from the opium poppy, which grows in many countries around the world with moderate climates.
Heroin: a powerful and highly addictive drug, heroin is a semi-synthetic drug derived from morphine. It is currently listed under Schedule I of the Single Convention on Narcotic Drugs (see below).
Fentanyls: a group of synthetic opioids that can be up to 1000 times more potent than heroin. Twenty three fentanyl compounds are listed under Schedule I of the Single Convention on Narcotic Drugs (see below).
Nitazenes: Up to 500 more potent than heroin, nitazenes are another group of synthetic opioids and are also classified as new psychoactive substances. Though they were originally developed in the 1950s as an alternative to morphine, nitazenes were never approved for medical use due to their high risk of respiratory depression. Twelve nitazenes are currently under international control, meaning governments have limited the possession, use, trade in, distribution, import, export, manufacture and production of drugs exclusively to medical and scientific purposes.
Orphines: another group of synthetic opioids originally developed in the 1960s by medical researchers for their anesthetic properties. Many have a higher potency than drugs like heroin. First reported to UNODC’s Early Warning Advisory (EWA) in 2019, one orphine (Brorphine) was placed under international control in 2022. Ten additional orphine analogues were reported to the EWA as of February 2026.